Deconstructing gelsolin: Identifying sites that mimic or alter binding to actin and phosphoinositides

Chemistry and Biology

Volumn 5, Issue 4, 1998, Pages

  Janmey, Paul A ^a   Stossel, Thomas P ^a   Allen, Philip G ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0032053766     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(98)90631-7     Document Type: Short Survey

References (28)

1. McLaughlin, P.J., Gooch, J.T., Mannherz, H.G. & Weeds, A.G. (1993). Structure of gelsolin segment 1-actin complex and the mechanism of filament severing. Nature 364, 685-692.
2. Burtnick, L.D., et al. & Robinson, R.C. (1997). The crystal structure of plasma gelsolin - implications for actin severing, capping, and nucleation. Cell 90, 661-670.
3. Kwiatkowski, D.J., et al. & Yin, H.L. (1986). Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain. Nature 323, 455-458.
4. Stossel, T.P. (1994). The machinery of cell crawling. Sci. Am. 271, 54-63.
5. Steed, P.M., Nagar, S. & Wennogle, L.P. (1996). Phospholipase D regulation by a physical interaction with the actin-binding protein gelsolin. Biochem. 35, 5229-5237.
6. Cunningham, C.C., Stossel, T.P. & Kwiatkowski, D.J. (1991). Enhanced motility in NIH 3T3 fibroblasts that overexpress gelsolin. Science 251, 1233-1236.
7. Sun, H.Q., Lin, K.M. & Yin, H.L (1997). Gelsolin modulates phospholipase C activity in vivo through phospholipid binding. J. Cell. Biol. 138, 811-820.
8. Witke, W., et al. & Kwiatkowski, D.J. (1995). Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell 81, 41-51.
9. Arora, P.D. & McCulloch, C.A.G. (1996). Dependence of fibroblast migration on actin severing activity of gelsolin. J. Biol. Chem. 271, 20516-20523.
10. Azuma, T., Witke, W., Stossel, T., Hartwig, J. & Kwiatkowski, D. (1998). Gelsolin is a downstream effector of rac for fibroblast motility. EMBO J. 17, 1362-1370.
11. Lee, W. & Galbraith, R. (1992). Review Article - Mechanisms of disease: the extracellular actin-scavenger system and actin toxicity. New Engl. J. Med. 326, 1335-1341.
12. Maury, C., Sletten, K., Totty, N., Kangas, H. & Liljestrom, M. (1997). Identification of the circulating amyloid precursor and other gelsolin metabolites in patients with g654a mutation in the gelsolin gene (finnish familial amyloidosis) - pathogenetic and diagnostic implications. Lab. Invest. 77, 299-304.
13. Kothakota, S., et al. & Williams, L.T. (1997). Caspase-3-generated fragment of gelsolin - effector of morphological change in apoptosis. Science 278, 294-298.
14. Ohtsu, M., et al. & Kuzumaki, N. (1997). Inhibition of apoptosis by the actin-regulatory protein gelsolin. EMBO J. 16, 4650-4656.
15. Furukawa, K., et al. & Mattson, M.P. (1997). The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons. J. Neurosci. 17, 8178-8186.
16. Chaponnier, C. & Gabbiani, G. (1989). Gelsolin modulation in epithelial and stromal cells of mammary carcinoma. Am. J. Pathol. 134, 597-603.
17. Dosaka Akita, H., et al. & Kuzumaki, N. (1998). Frequent loss of gelsolin expression in non-small cell lung cancers of heavy smokers. Cancer Res. 58, 322-327.
18. Ishizaki, A., Fujita, H. & Kuzumaki, N. (1995). Growth-inhibitory functions of a mutated gelsolin (His321) in NIH/3T3 mouse fibroblasts. Exp. Cell Res. 217, 448-452.
19. Kwon, H. J., et al. & Horinouchi, S. (1997). Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression. Oncogene 15, 2625-2631.
20. De Corte, V., Gettemans, J. & Vandekerckhove, J. (1997). Phosphatidylinositol 4,5-bisphosphate specifically stimulates PP60(c-src) catalyzed phosphorylation of gelsolin and related actin-binding proteins. FEBS Lett. 401, 191-196.
21. Pope, B., Maciver, S. & Weeds, A. (1995). Localization of the calciumsensitive actin monomer binding site in gelsolin to segment 4 and identification of calcium binding sites. Biochemistry 34, 1583-1588.
22. Pope, B.J., Gooch, J.T. & Weeds, A.G. (1997). Probing the effects of calcium on gelsolin. Biochemistry 36, 15848-15855.
23. Pitcher, J.A., et al. & Lefkowitz, R.J. (1996). Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. J. Biol. Chem. 271, 24907-24913.
24. Xian, W., Vegners, R., Janmey, P.A. & Braunlin, W.H. (1995). Spectroscopic studies of a phosphoinositide-binding peptide from gelsolin: behavior in solutions of mixed solvent and anionic micelles. Biophys J. 69, 2695-2702.
25. Feinberg, J., Mery, J., Heitz, F., Benyamin, Y. & Roustan, C. (1997). Conformational and functional studies of three gelsolin subdomain-1 synthetic peptides and their implication in actin polymerization. Biopolymer 41, 647-655.
26. Wen, D., Corina, K., Chow, E., Miller, S., Janmey, P. & Pepinsky, R. (1996). The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure. Biochemistry 35, 9700-9709.
27. Ma, L., Cantley, L., Janmey, P. & Kirschner, M. (1998). Co-requirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts. J. Cell. Biol. 140, 1125-1136.
28. Cunningham, C.C., Janmey, P.A. & Vegners, R. (1998). Fluorescent derivatives of inositol lipid binding peptides. In Peptides 1996. (Ramage, R. & Epton, R. eds), pp 317-318, Mayflower, London.