EGF domain swap converts a Drosophila EGF receptor activator into an inhibitor

Genes and Development

Volumn 12, Issue 7, 1998, Pages 908-913

  Schnepp, Bruce ^a   Donaldson, Timothy ^a   Grumbling, Gary ^a   Ostrowski, Stephen ^a   Schweitzer, Ronen ^b,c   Shilo, Ben Zion ^b   Simcox, Amanda ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Argos; Drosophila; EGF; EGF receptor; Spitz; Vein

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CHIMERA; DROSOPHILA; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL;

EID: 0032053660     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.7.908     Document Type: Article

References (27)

1. Baker, N.E. and G.M. Rubin. 1989. Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor. Nature 340: 150-153.
2. Brand, A. and N. Perrimon. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
3. Clifford, R.T. and T. Schüpbach. 1989. Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene. Genetics 122: 771-787.
4. Egan, S.E. and R.A. Weinberg. 1993. The pathway to signal achievement. Nature 365: 781-783.
5. Freeman, M. 1994a. Misexpression of the Drosophila argos gene, a secreted regulator of cell determination. Development 120: 2297-2304.
6. _. 1994b. The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor. Mech. Dev. 48: 25-33.
7. _. 1996. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87: 651-660.
8. Freeman, M., C. Klämbt, C.S. Goodman, and G.M. Rubin. 1992. The argos gene encodes a diffusible factor that regulates cell fate in the Drosophila eye. Cell 69: 963-975.
9. Gabay, L., H. Scholz, M. Golembo, A. Klaes, B.-Z, Shilo, and C. Klämbt. 1996. EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. Development 122: 3355-3362.
10. Gabay, L., R. Seger, and B.-Z. Shilo. 1997. In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277: 1103-1106.
11. Golembo, M., R. Schweitzer, M. Freeman, and B.-Z. Shilo. 1996. argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. Development 122: 223-230.
12. González-Reyes, A., H. Elliott, and D. St Johnston. 1995. Polarization of both major body axes in Drosophila by gurken-torpedo signaling. Nature 375: 654-658.
13. Groenen, L.C., E.C. Nice, and A.W. Burgess. 1994. Structure-function relationships for the EGF/TGF-α family of mitogens. Growth Factors 11: 235-257.
14. Neuman-Silberberg, F. and T. Schüpbach. 1993. The Drosophila gene gurken produces a dorsally localized RNA and encodes a TGFα-like protein. Cell 75: 165-174.
15. Perrimon, N. and L.A. Perkins. 1997. There must be 50 ways to rule the signal: The case of the Drosophila EGF receptor. Cell 89: 13-16.
16. Rutledge, B.J., K. Zhang, E. Bier, Y.N. Jan, and N. Perrimon. 1992. The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes & Dev. 6: 1503-1517.
17. Sawamoto, K., H. Okano, Y. Kobayakawa, S. Hayashi, K. Mikoshiba, and T. Tanimura. 1994. The function of argos in regulating cell fate decisions during Drosophila eye and wing vein development. Dev. Biol. 164: 267-276.
18. Schnepp, B., G. Grumbling, T. Donaldson, and A. Simcox. 1996. Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes & Dev. 10: 2302-2313.
19. Schweitzer, R. and B.-Z. Shilo. 1997. A thousand and one roles for the Drosophila EGF receptor. Trends Genet. 13: 191-196.
20. Schweitzer, R., R. Howes, R. Smith, B.-Z. Shilo, and M. Freeman. 1995a. Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376: 699-702.
21. Schweitzer, R., M. Shaharabany, R. Seger, and B.-Z. Shilo. 1995b. Secreted spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes & Dev. 9: 1518-1529.
22. Simcox, A. 1997. Differential requirement for EGF-like ligands in Drosophila wing development. Mech. Dev. 62: 41-50.
23. Simcox, A., G. Grumbling, B. Schnepp, C. Bennington-Mathias, E. Hersperger, and A. Shearn. 1996. Molecular, phenotypic, and expression analysis of vein, a gene required for growth of the Drosophila wing disc. Dev. Biol. 177: 475-489.
24. Sturtevant, M.A., M. Roark, and E. Bier. 1993. The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes & Dev. 7: 961-973.
25. van de Poll, M.L.M., M.J.H. van Vugt, A.E.G. Lenferink, and E.J.J. van elen. 1997. Insertion of Argos sequences into the B-loop of epidermal growth factor results in a low-affinity ligand with strong agonistic activity. Biochemistry 36: 7425-7431.
26. Wieschaus, E., N. Perrimon, and R. Finkelstein. 1992. Orthodenticle activity is required for the development of medial structures in the larval and adult epidermis of Drosophila. Development 115: 801-811.
27. Yarnitzky, T., L. Min, and T. Volk. 1997. The Drosophila neuregulin homolog Vein mediates inductive interactions between myotubes and their epidermal attachment cells. Genes & Dev. 11: 2691-2700.