Insertion of argos sequences into the B-loop of epidermal growth factor results in a low-affinity ligand with strong agonistic activity

Biochemistry

Volumn 36, Issue 24, 1997, Pages 7425-7431

  Van De Poll, Monique L M ^a   Van Vugt, Marianne J H ^a   Lenferink, Anne E G ^a   Van Zoelen, Everardus J J ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE;

AGONIST; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVATION; GENE INSERTION; LIGAND BINDING; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BINDING, COMPETITIVE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; DROSOPHILA PROTEINS; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; ESCHERICHIA COLI; EYE PROTEINS; GENE EXPRESSION; HUMANS; MITOGENS; MUTAGENESIS; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0030900908     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970227f     Document Type: Article

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