Differential effects of endomorphin-1, endomorphin-2, and Tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes

Peptides

Volumn 19, Issue 4, 1998, Pages 749-753

  Harrison, Laura M ^a   Kastin, Abba J ^a   Zadina, James E ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

35S GTP S binding; Endomorphin 1; Endomorphin 2; G proteins; Tyr W MIF 1

Indexed keywords

ENDORPHIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DERIVATIVE; MU OPIATE RECEPTOR; PROTEIN;

ARTICLE; BINDING AFFINITY; NEUROBLASTOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MSH RELEASE-INHIBITING HORMONE; NEUROBLASTOMA; OLIGOPEPTIDES; RECEPTORS, OPIOID; TUMOR CELLS, CULTURED;

BOVINAE;

EID: 0032051847     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(98)00022-9     Document Type: Article

References (21)

1. 35S]GTPγS binding: a tool to evaluate functional activity of a cloned opioid receptor transiently expressed in COS cells. Neurochem. Res. 21:1996;1301-1307.
2. 6 glioma cell line expressing the μ opioid receptor. J. Pharmacol. Exp. Ther. 278:1996;1121-1127.
3. 2 (Tyr-W-MIF-1) . Peptides. 13:1992;623-631.
4. Erchegyi J., Zadina J. E., Qui X.-D., Kersh D., Ge L.-J., Brown M. M., Kastin A. J. Structure-activity relationships of analogs of the endogenous brain peptides Tyr-MIF-1 and Tyr-W-MIF-1. Pept. Res. 6:1993;31-38.
5. x/z transducer proteins in mouse periaqueductal gray matter. J. Pharmacol. Exp. Ther. 281:1997;549-557.
6. 2-adrenoceptors. Eur. J. Pharmacol. 298:1996;235-239.
7. 1-opioid receptor antagonist . Eur. J. Pharmacol. 316:1996;33-38.
8. Hackler L., Zadina J. E., Ge L.-J., Kastin A. J. Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex. Peptides. 18:1997;1635-1639.
9. Harrison L. M., Kastin A. J., Zadina J. E. Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells. J. Pharmacol. Exp. Ther. 284:1998;611-617.
10. Prather P. L., Tsai A.W., Law P.Y. Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SH-SY5Y cells. J. Pharmacol. Exp. Ther. 270:1994;177-184.
11. Selley D. E., Sim L. J., Xiao R., Liu Q., Childers S. R. μ-Opioid receptor-stimulated guanosine-5′-O-(γ-thio)-triphosphate binding in rat thalamus and cultured cell lines signal transduction mechanisms underlying agonist efficacy . Mol. Pharmacol. 51:1997;87-96.
12. Sim L. J., Selley D. E., Xiao R., Childers S. R. Differences in G-protein activation by μ- and δ-opioid, and cannabinoid, receptors in rat striatum. Eur. J. Pharmacol. 307:1996;97-105.
13. 35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol. Pharmacol. 47:1995;848-854.
14. Yu V. C., Eiger S., Duan D.-S., Lameh J., Sadee W. Regulation of cyclic AMP by the μ-opioid receptor in human neuroblastoma SH-SY5Y cells. J. Neurochem. 55:1990;1390-1396.
15. Yu V. C., Sadee W. Efficacy and tolerance of narcotic analgesics at the mu opioid receptor in differentiated human neuroblastoma cells. J. Pharmacol. Exp. Ther. 245:1988;350-355.
16. Zadina J. E., Chang S.-L., Ge L.-J., Kastin A. J. Mu opiate receptor down-regulation by morphine and up-regulation by naloxone in SH-SY5Y human neuroblastoma cells. J. Pharmacol. Exp. Ther. 265:1993;254-262.
17. Zadina J. E., Hackler L., Ge L.-J., Kastin A.J. A potent and selective endogenous agonist for the μ-opiate receptor. Nature (London). 386:1997;499-502.
18. Zadina J. E., Harrison L. M., Ge L.-J., Kastin A. J., Chang S. L. Differential regulation of mu and delta opiate receptors by morphine, selective agonists and antagonists and differentiating agents in SH-SY5Y human neuroblastoma cells. J. Pharmacol. Exp. Ther. 270:1994;1086-1096.
19. Zadina J. E., Kastin A. J., Ge L.-J., Hackler L. Mu, delta, and kappa opiate receptor binding of Tyr-MIF-1 and of Tyr-W-MIF-1, its active fragments, and two potent analogs. Life Sci. 55:1994;L461-PL466.
20. 2). Neurosci. Lett. 155:1993;220-222.
21. Zadina J. E., Kastin A. J., Kersh D., Wyatt A. Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum. Life Sci. 51:1992;869-885.