Opioids binding mu and delta receptors exhibit diverse efficacy in the activation of G(i2) and G(x/z) transducer proteins in mouse periaqueductal gray matter

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 1, 1997, Pages 549-557

  Garzón, Javier ^a   García España, Antonio ^a   Sánchez Blázquez, Pilar ^a  

^a CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA OPIATE RECEPTOR; MU OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BRAIN MEMBRANE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; GENE ASSIGNMENT; IMMUNOELECTROPHORESIS; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); IMMUNOELECTROPHORESIS; MALE; MICE; MOLECULAR SEQUENCE DATA; PERIAQUEDUCTAL GRAY; RABBITS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU;

EID: 0030910987     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase. Naunyn-Schmiedeberg Arch. Pharmacol. 324: 196-200, 1993.
2. 2A-adrenergic receptor to multiple G-proteins. J. Biol. Chem. 269: 5730-5734, 1994.
3. CHRISTIE, M. J., WILLIAMS, J. T. AND NORTH, R. A.: Cellular mechanisms of opioid tolerance: Studies in single brain neurons. Mol. Pharmacol. 32: 633-638, 1987.
4. COULTER, S. AND RODBELL, M.: Heterotrimeric G proteins in synaptosome membranes are crosslinked by p-phenylenedimaleimide, yielding structures comparable in size to crosslinked tubulin and F-actin. Proc. Natl. Acad. Sci. U.S.A. 89: 5842-5846, 1992.
5. COSTA, T. AND HERZ, A.: Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins. Proc. Natl. Acad. Sci. U.S.A. 86: 7321-7325, 1989.
6. DUNBAR, B. S.: Antibody preparation, detection, and characterization techniques. In Two-Dimensional Electrophoresis and Immunological Techniques. Plenum Press. New York. pp. 303-334, 1987.
7. 12 transducer proteins. Life Sci./Pharmacol. Lett. 55: PL 205-212, 1994.
8. GARZÓN, J.: Cellular transduction regulated by μ- and δ-opioid receptors in supraspinal analgesia: GTP binding regulatory proteins as pharmacological targets. Analgesia 1: 131-144, 1995.
9. q-transducer proteins in the production of supraspinal analgesia in the mouse. Analgesia 1: 429-432, 1995.
10. GEORGOUSSI, Z. AND ZIOUDROU, C.: Effect of δ-opioid antagonists on the functional coupling between opioid receptors and G-proteins in rat brain membranes. Biochem. Pharmacol. 45: 2405-2410, 1993.
11. GOLDSMITH, P., BACKLUND J. R., P. S., ROSSITER, K., CARTER, A., MILLIGAN, G., UNSON, C. G. AND SPIEGEL. A.: Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go. Biochemistry 27: 7085-7090, 1988.
12. HUIDOBRO, F., HUIDOBRO-TORO, J. P. AND MIRANDA, H.: Interaction between morphine and the opioid-like peptides in the rat vas deferens. Br. J. Pharmacol. 70: 519-525, 1980.
13. JAHANGEER, S. AND RODBELL, M.: The disaggregation theory of signal transduction revisited: Further evidence that G proteins are multimeric and disaggregate to monomers when activated. Proc. Natl. Acad. Sci. U.S.A. 90: 8782-8786, 1993.
14. JENSEN, T. S. AND YAKSH, T. L.: III. Comparison of the antinociceptive action of mu and delta opioid receptor ligands in the periaqueductal grey matter, medial and paramedial ventral medulla in the rat as studied by the micro-injection technique. Brain Res. 372: 301-312, 1986.
15. JONES, D. T. AND REED, R. R.: Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J. Biol. Chem. 262: 14241-14249, 1987.
16. KENAKIN, T.: Agonist-receptor efficacy II: agonist trafficking of receptor signals. Trends Pharmacol. Sci. 16: 232-238, 1995.
17. KOSTKRLITZ, H. W., LORD, J. A. H., PATKRSON, S. J. AND WATERFIELD, A. A.: Effects of changes in the structure of enkephalins and of narcotic analgesic drugs on their interactions with μ.- and δ-receptors. Br. J. Pharmacol. 68: 333-342, 1980.
18. LAUGWITZ, K. L., OFFERMANNS, S., SPICHER, K. AND SCHULTZ, G.: μ and δ opioid receptors differentially couple to G protein subtypes in membranes of human neuroblastoma SH-SY5Y cells. Neuron 10: 233-242, 1993.
19. LAURELL, C. B.: Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal. Biochem. 15: 45-52, 1966.
20. iα1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this a subunit necessary for mediating the inhibition by somatostatin of cAMP formation. Mol. Pharmacol. 45: 587-590, 1994.
21. LEWIS, J. M., WOOLKALIS, M. J., GERTON, G. L., SMITH, R. M., JARRET. L. AND MANNING, D. R.: Subcellular distribution of the α summit(s) of Gi: Visualization by immunofluorescent and immunogold labelling. Cell Regul. 2: 1097-1113, 1991.
22. LOWRY, O. H., ROSEBROUGH, N. J., PARR, A. L. AND RANDALL, R. J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
23. i2 in GH4C1 pituitary cells. J. Biol. Chem. 269: 13880-13886, 1994.
24. LUTZ, R. A., CRUCIANI, R. A., COSTA, T., MUNSON, P. J. AND RODBARD, D.: A very high affinity opioid binding site in rat brain: demonstration by computer modelling. Biochem. Biophys. Res. Commun. 122: 265-269, 1984.
25. LUTFY, K., CHANG, S. C., CANDIDO, J., JANG, Y., SIERRA, V. AND YOBURN, B. C.: Modification of morphine-induced analgesia and toxicity by pertussis toxin. Brain Res. 544: 191-195, 1991.
26. MATSUOKA, M., ITOH, H. AND KAZIRO, Y.: Characterization of the human gene for Gxα, a pertussis toxin-insensitive regulatory GTP-binding protein. J. Biol. Chem. 265: 13215-13220, 1990.
27. o, from the plasma membrane of NG108-15 cells. Biochem. Biophys. Res. Commun. 152: 243-251, 1988.
28. MILLIGAN, G.: Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells. Biochim. Biophys. Acta 929: 197-202, 1987.
29. s promotes its removal from the plasma membrane. Biochem. J. 260: 837-841, 1989.
30. MULLANEY, I., CARR, I. C. AND MILLIGAN, G.: Analysis of inverse agonism at the δ opioid receptor after expression in rat 1 fibroblasts. Biochem. J. 315: 227-234, 1996.
31. NAKAMURA, S. I. AND RODBELL, M.: Octyl glucoside extracts GTP-binding regulatory proteins from rat brain "synaptoneurosomes" as large, polydisperse structures devoid of βγ complexes and sensitive to disaggregation by guanine nucleotides. Proc. Acad. Sci. U.S.A. 87: 6413-6417, 1990.
32. NEUBIG, R. R.: Membrane organization in G-protein mechanisms. FASEB J. 8: 939-946, 1994.
33. q/11. Mol. Pharmacol. 45: 890-898, 1994.
34. PARENTI, M., TIRONE, F., GIAGNONI, G., PECORA, N. AND PAKOLANO, D.: Pertussis toxin inhibits the antinociceptive action of morphine in the rat. Eur. J. Pharmacol. 124: 357-360, 1986.
35. PASTERNAK, G. W., CHILDERS, S. R. AND SNYDER, S. H.: Opiate analgesia: evidence for mediation by a subpopulation of opiate receptors. Science 208: 514-516, 1980.
36. PORRECA, F. AND BURKS, T. F.: Affinity of normorphine for its pharmacologic receptor in the naive and morphine-tolerant guinea-pig isolated ileum. J. Pharmacol. Exp. Ther. 225: 688-693, 1983.
37. RAFFA, R. B., MARTÍNEZ, R. P. AND CONNELLY, C. D.: G-protein antisense oligodeoxyribonucleotides and μ,-opioid supraspinal antinociception. Eur. J. Pharmacol. 258: R5-R7, 1994.
38. RUHRIG, S. C., LOH, H. H. AND LAW, P. Y.: Identification of three separate guanine nucleotide-binding proteins that interact with the 6-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells. Mol. Pharmacol. 41: 822-831, 1992.
39. ROSSI, G. C., STANDIFER, K. M. AND PASTERNAK, G. W.: Differential blockade of morphine and morphine-6β-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein α subunits in rats. Neurosci. Lett. 198: 99-102, 1995.
40. SÁNCHEZ-BLÁZQUEZ, P. AND GARZÓN, J.: Pertussis toxin differentially reduces the efficacy of opioids to produce supraspinal analgesia in the mouse. Eur. J. Pharmacol. 152: 357-361, 1988.
41. SÁNCHEZ-BLÁZQUEZ, P. AND GARZÓN, J.: Evaluation of δ receptor mediation of supraspinal opioid analgesia by in vivo protection against the β-funaltrexamine antagonist effect. Eur. J. Pharmacol. 159: 9-23, 1989.
42. 2-mediated supraspinal analgesia in mice. Life Sci. 48: 1721-1727, 1991.
43. i3 transducer proteins. Life Sci./Pharmacol. Lett. 53: PL 129-134, 1993.
44. i2 transducer proteins on μ/δ opioid-mediated supraspinal antinociception. Life Sci./Pharmacol. Lett. 53: PL 381-386, 1993.
45. SÁNCHEZ-BLÁZQUEZ, P., GARCÍA-ESPAÑA, A. AND GARZÓN, J.: vivo injection of oligodeoxynucleotides to Gα subunits and supraspinal analgesia evoked by mu and delta opioid agonists. J. Pharmacol. Exp. Ther. 275: 1590-1596, 1995.
46. SARGIACOMO, M., SUDOL, M., TANG, Z. L. AND LISANTI, M. P.: Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolinrich insoluble complex in MDCK cells. J. Cell Biol. 122: 789-807, 1993.
47. SPICHER, K., NÜRNBERG, B., JÄGER, B., ROSENTHAL, W. AND SCHULZ, G.: Heterogeneity of three electrophoretically distinct Go α-subunits in mammalian brain. FEBS Lett. 307: 215-218, 1992.
48. STANDIFER, K. M., Rossi, G. C. AND PASTERNAK, G. W.: Differential blockade of opioid analgesia by antisense oligodeoxynucleotides directed against various G protein a subunits. Mol. Pharmacol. 50: 293-298, 1996.
49. SUNYER, T., MONASTIRSKY, B., CODINA, J. AND BIRNBAUMER, L.: Studies on nucleotide and receptor regulation of Gi proteins: Effects of pertussis toxin. Mol. Endocrinol. 3: 1115-1124, 1989.
50. i2 protein α subunit sequence inhibits an opioid-induced increase in the intracellular free calcium concentration in ND8-47 neuroblastoma × dorsal root ganglion hybrid cells. Mol. Pharmacol. 48: 189-193, 1995.
51. 4]deltorphin with δ-opioid receptor subtypes in vivo. Eur. J. Pharmacol. 252: 133-137, 1994.
52. VAN DOP, C., YAMANAKA, G., STEINBERG, F., SEKURA, R. D., MANCLARK, C. R., STRYER, L. AND BOURNE, H. R.: ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors. J. Biol. Chem. 259: 23-26, 1984.
53. WEINGARTEN, R., RANSNAS, L., MUELLER, H., SKLAR, L. A. AND BOKOCH, G. M.: Mastoparan interacts with the carboxyl terminus of the alpha subunit of Gi. J. Biol. Chem. 265: 11044-11049, 1990.
54. WINSLOW, J. W., VAN AMSTERSAM, J. R. AND NEER, E. J.: Conformations of the α39, α41, and α.γ components of brain guanine nucleotide-binding proteins. J. Biol. Chem. 261: 7571-7579, 1986.
55. 2+- and temperature-sensitive GTP-binding protein. Biochem. J. 232: 191-197, 1985.
56. WONG, Y. H., DEMOLIOU-MASON, C. D. AND BARNARD, E. A.: ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes. J. Neurochem. 51: 114-121, 1988.
57. YAKSH, T. L., YEUNG, J. C. AND RUDY, T. A.: Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal grey. Brain Res. 114: 83-103, 1976.
58. o protein subunits. J. Biol. Chem. 266: 3900-3906, 1991.