Helper T-Cell Epitopes Encoded by the Babesia bigemina rap-1 Gene Family in the Constant and Variant Domains Are Conserved among Parasite Strains

Infection and Immunity

Volumn 66, Issue 4, 1998, Pages 1561-1569

  Brown, Wendy C ^a   McElwain, Terry F ^a   Hötzel, Isidro ^a   Suarez, Carlos E ^a   Palmer, Guy H ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; PROTOZOAL PROTEIN; PROTOZOAL VACCINE; RHOPTRY ASSOCIATED PROTEIN, PLASMODIUM;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BABESIA; CATTLE; CHEMISTRY; EPITOPE MAPPING; GENETICS; HELPER CELL; IMMUNIZATION; IMMUNOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

AMINO ACID SEQUENCE; ANIMALS; BABESIA; CATTLE; CONSERVED SEQUENCE; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; IMMUNIZATION; MOLECULAR SEQUENCE DATA; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0032036477     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.4.1561-1569.1998     Document Type: Article

References (45)

1. Brown, W. C., D. M. Estes, S. D. Rodriguez, B. J. Ruef, W. Tuo, T. F. McElwain, and G. H. Palmer. 1997. Babesia bigemina rhoptry-associated protein 1 (RAP-1) induces a type 1 cytokine response and both IgG1 and IgG2 antibody subclasses, p. 30. In Proceedings from the Society for Tropical Veterinary Medicine, 4th Biennial Meeting, Montpellier, France.
2. Brown, W. C., K. S. Logan, G. G. Wagner, and C. L. Tetzlaff. 1991. Cell-mediated immune responses to Babesia bovis merozoite antigens in cattle following infection with tick-derived or cultured parasites. Infect. Immun. 59:2418-2426.
3. Brown, W. C., T. F. McElwain, B. J. Ruef, C. E. Suarez, V. Shkap, C. G. Chitko-McKown, W. Tuo, A. C. Rice-Ficht, and G. H. Palmer. 1996. Babesia bovis rhoptry-associated protein 1 is immunodominant for T helper cells of immune cattle and contains T-cell epitopes conserved among geographically distant B. bovis strains. Infect. Immun. 64:3341-3350.
4. Brown, W. C., and A. C. Rice-Ficht. 1994. Use of helper T cells to identify potentially protective antigens of Babesia bovis. Parasitol. Today 10:145-149.
5. + T cell clones activated in vitro. Infect. Immun. 61:3273-3281.
6. Calvo, M., F. Guzman, E. Perez, C. H. Segura, A. Molano, and M. E. Patarroyo. 1991. Specific interactions of synthetic peptides derived from P. falciparum merozoite proteins with human red blood cells. Peptide Res. 4:324-332.
7. Collins, W. E., D. Pye, P. E. Crewther, K. L. Vandenberg, G. G. Galland, A. J. Sulzer, D. J. Kemp, S. J. Edwards, R. L. Coppel, J. S. Sullivan, C. L. Morris, and R. F. Anders. 1994. Protective immunity induced in squirrel monkeys with recombinant apical membrane antigen-1 of Plasmodium fragile. Am. J. Trop. Med. Hyg. 51:711-719.
8. Dalrymple B. P., R. E. Casu, J. M. Peters, C. M. Dimmock, K. R. Gale, R. Boese and I. G. Wright. 1993. Characterisation of a family of multi-copy genes encoding rhoptry protein homologues in Babesia bovis. Babesia ovis and Babesia canis. Mol. Biochem. Parasitol. 57:181-12.
9. Dalrymple, B. P., J. M. Peters, R. Böse, and I. G. Wright. 1996. A polymerase chain reaction method for the identification of genes encoding members of the Bv60/p58 family of rhoptry protein homologues in the genus Babesia. Exp. Parasitol. 84:96-100.
10. Echaide, I. E., S. T. de Echaide, and A. A. Gugliemone. 1993. Live and soluble antigens for cattle afford protection to Babesia bigemina. Vet. Parasitol. 51:35-40.
11. 2 production from hovine B cells costimulated with anti-μ and mitogen. Cell. Immunol. 154:287-295.
12. Evavold, B. D., J. Moan-Lancaster, and P. M. Allen. 1993. Tickling the TCR: selective T-cell functions stimulated by altered peplide ligands. Immunol. Today 14:602-609.
13. Feller, D. C., and V. F. de la Cruz. 1991. Identifying antigenic T-cell sites. Nature 349:720-721.
14. Goff, W. L., W. C. Davis, G. H. Palmer, T. F. McElwain, W. C. Johnson, J. F. Bailey, and T. C. McGuire. 1988. Identification of Babesia bovis merozoite surface antigens by using immune bovine sera and monoclonal antibodies. Infect. Immun. 56:2363-2368.
15. + T helper lymphocyte epitopes in the Babesia bigemina rhoptry associated protein-1. Mol. Biochem. Parasitol. 81:89-99.
16. Hötzel, I., C. E. Suarez, T. F. McElwain, and G. H. Palmer. 1998. Genetic variation in the dimorphic regions of rap-1 genes and rap-1 loci of Babesia bigemina. Mol. Biochem. Parasitol. 90:479-489.
17. Howard, R. J., and B. L. Pasloske. 1993. Target antigens for asexual malaria vaccine development. Parasitol. Today 9:369-372.
18. Krzych, U., T. Jareed, H. T. Link, L. D. Loomis, and W. R. Ballou. 1992. Distinct T cell specificities are induced with the authentic versus recombinant Plasmodium berghei circumsporozoite protein. J. Immunol. 148:2530-2538.
19. Lal, A. A., M. A. Hughes, D. A. Oliveira, C. Nelson, P. B. Bloland, A. J. Oloo, W. E. Hawley, A. W. Hightower, B. L. Nahlen, and V. Udhayakumar. 1996. Identification of T-cell determinants in natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in an adult population exposed to malaria. Infect. Immun. 64:1054-1059.
20. Machado, R. Z., G. H. Palmer, and T. F. McElwain. 1997. Vaccination of cattle with Babesia bigemina rhoptry proteins, p. 46. In Proceedings from the Society for Tropical Veterinary Medicine 4th Biennial Meeting, Montpellier, France.
21. Madruga, C. R., C. E. Suarez, T. F. McElwain, and G. H. Palmer. 1996. Conservation of merozoite membrane and apical complex B cell epitopes among Babesia bigemina and Babesia bovis strains isolated in Brazil. Vet. Parasitol. 61:21-30.
22. Margalit, H., J. L. Spouge, J. L. Cornette, K. B. Cease, C. DeLisi, and J. A. Berzofsky. 1987. Prediction of immunodominant helper T cell antigenic sites from the primary sequence. J. Immunol. 138:2213-2229.
23. McElwain, T. F., L. E. Ferryman, W. C. Davis, and T. C. McGuire. 1987. Antibodies define multiple proteins with epitopes exposed on the surface of live Babesia bigemina merozoites. J. Immunol. 138:2298-2304.
24. McElwain, T. F., L. E. Perryman, A. J. Musoke, and T. C. McGuire. 1991. Molecular characterization and immunogenicity of neutralization-sensitive Babesia bigemina merozoite surface proteins. Mol. Biochem. Parasitol. 47: 213-222.
25. Mishra, V. S., T. F. McElwain, J. B. Dame, and E. B. Stephens. 1992. Isolation, sequence, and differential expression of the p58 gene family of Babesia bigemina. Mol. Biochem. Parasitol. 53:149-158.
26. Mishra, V. S., E. B. Stephens, J. B. Dame, L. E. Perryman, T. C. McGuire, and T. F. McElwain. 1991. Immunogenicity and sequence analysis of recombinant p58: a neutralization-sensitive, antigenically conserved Babesia bigemina merozoite surface protein. Mol. Biochem. Parasitol. 47:207-212.
27. Musoke, A. J., F. R. Rurangirwa, and V. M. Nantulya. 1986. Biological properties of bovine immunoglobulins and systemic antibody responses, p. 391-408. In W. I. Morrison (ed.), The ruminant immune system in health and disease. Cambridge University Press, Cambridge, England.
28. Oliviera, D. A., V. Udhayakumar, P. Bloland, Y. P. Shi, B. L. Nahlen, A. J. Oloo, W. E. Hawley, and A. A. Lal. 1996. Genetic conservation of the Plasmodium falciparum apical membrane antigen-1 (AMA-1). Mol. Biochem. Parasitol. 76:333-336.
29. Palmer, G. H., and T. F. McElwain. 1995. Molecular basis for vaccine development against anaplasmosis and babesiosis. Vet. Parasitol. 57:233-253.
30. Palmer, G. H., T. F. McElwain, L. E. Perryman, W. C. Davis, D. R. Reduker, D. P. Jasmer, V. Shkap, E. Pipano, W. L. Goff, and T. C. McGuire. 1991. Strain variation of Babesia bovis merozoite surface-exposed epitopes. Infect. Immun. 59:3340-3342.
31. Perkins, M. E. 1992. Rhoptry organelles of apicomplexan parasites. Parasitol. Today 8:28-32.
32. Rockett, K. A., M. M. Awburn, B. B. Aggarwal, W. B. Cowden, and I. A. Clark. 1992. In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interleukin-1: possible roles in malaria. Infect. Immun. 60:3725-3730.
33. Rockett, K. A., M. M. Awburn, W. B. Cowden, and I. A. Clark. 1991. Killing of Plasmodium falciparum in vitro by nitric oxide derivatives. Infect. Immun. 59:3280-3283.
34. + T-helper lymphocyte responses against Babesia bigemina rhoptry-associated protein 1. Infect. Immun. 64:2079-2087.
35. Ruef, B. J., S. D. Rodriguez, A. J. Roussel, G. H. Palmer, T. F. McElwain, C. G. Chitko-McKown, A. C. Rice-Ficht, and W. C. Brown. 1997. Immunization with Babesia bigemina rhoptry-associated protein 1 induces a type 1 cytokine response. J. Interferon Cytokine Res. 17:45-54.
36. Sam-Yellowe, T. Y. 1996. Rhoptry organelles of the apicomplexa: their role in host cell invasion and intracellular survival. Parasitol. Today 12:308-316.
37. Shompole, S., T. F. McElwain, D. P. Jasmer, S. A. Hines, J. Katende, A. J. Musoke, F. R. Rurangirwa, and T. C. McGuire. 1994. Identification of Babesia bigemina infected erythrocyte surface antigens containing epitopes conserved among strains. Parasite Immunol. 16:119-127.
38. Skuce, P. J., T. R. Mallon, and S. M. Taylor. 1996. Molecular cloning of a putative rhoptry associated protein homologue from Babesia divergent. Mol. Biochem. Parasitol. 77:99-102.
39. Suarez, C. E., T. F. McElwain, E. B. Stephens, V. S. Mishra, and G. H. Palmer. 1991. Sequence conservation among merozoite apical complex proteins of Babesia bovis, Babesia bigemina and other apicomplexa. Mol. Biochem. Parasitol. 49:329-332.
40. Suarez, C. E., G. H. Palmer, D. P. Jasmer, S. A. Hines, L. E. Perryman, and T. F. McElwain. 1991. Characterization of the gene encoding a 60-kilodalton Babesia bovis merozoite protein with conserved and surface exposed epitopes. Mol. Biochem. Parasitol. 46:45-52.
41. Suarez, C. E., S. M. Thompson, T. F. McElwain, S. A. Hines, and G. H. Palmer. 1994. Conservation of oligopeptide motifs in rhoptry proteins from different genera of erythrocytic protozoa. Exp. Parasitol. 78:246-251.
42. Thomas, A. W., A. P. Waters, and D. Carr. 1990. Analysis of variation in PF83, an erythrocytic merozoite vaccine candidate antigen of Plasmodium falciparum. Mol. Biochem. Parasitol. 42:285-288.
43. Ushe, T. C., G. H. Palmer, L. Sotomayor, J. V. Figueroa, G. M. Buening, L. E. Perryman, and T. F. McElwain. 1994. Antibody response to Babesia bigemina rhoptry-associated protein-1 surface-exposed and neutralization-sensitive epitope in immune cattle. Infect. Immun. 62:5698-5701.
44. Vidotto, O., T. F. McElwain, R. Z. Machado, L. E. Perryman, C. E. Suarez, and G. H. Palmer. 1996. Babesia bigemina: identification of B cell epitopes associated with parasitized erythrocytes. Exp. Parasitol. 81:491-500.
45. Wright, I. G., R. Casu, M. A. Commins, B. P. Dalrymple, K. R. Gale, B. V. Goodger, P. W. Riddles, D. J. Waltisbuhl, I. Abetz, D. A. Berrie, Y. Bowles, C. Dimmock, T. Hayes, H. Kalnins, G. Leatch, R. McCrae, P. E. Montague, I. T. Nisbet, F. Parrodi, J. M. Peters, P. C. Scheiwe, W. Smith, K. Rode-Bramanis, and M. A. White. 1992. The development of a recombinant Babesia vaccine. Vet. Parasitol. 44:3-13.