Inhibition of murine AIDS by a new azidothymidine homodinucleotide

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 17, Issue 3, 1998, Pages 189-195

  Magnani, M ^a   Casabianca, A ^a   Fraternale, A ^a   Brandi, G ^a   Chiarantini, L ^a   Benatti, U ^b   Scarfi S ^b   Millo, E ^b   De Flora, A ^b  

^a UNIVERSITY OF URBINO   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

AZT; AZTp2AZT; Combination therapy; Murine; Retrovirus induced immunodeficiency

Indexed keywords

DNA; IMMUNOGLOBULIN G; ZIDOVUDINE; ZIDOVUDINE DERIVATIVE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; CONTROLLED STUDY; DNA CONTENT; ERYTHROCYTE COUNT; FEMALE; HEMATOCRIT; INTRAPERITONEAL DRUG ADMINISTRATION; LYMPHADENOPATHY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RODENT DISEASE; SPLENOMEGALY;

ANIMALIA; MURINAE; RNA VIRUSES; RODENTIA; UNIDENTIFIED RETROVIRUS;

EID: 0032031562     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199803010-00001     Document Type: Article

References (38)

1. Gartner S, Markovits P, Markovits DM, Kaplan MH, Gallo RC, Popovic M. The role of mononuclear phagocytes in HTLV-III/ LAV infection. Science 1996;233:215-9.
2. Ho DD, Rota TR, Hirsch MS. Infection of monocyte/macrophages by human T/lymphotropic virus type III. J Clin Invest 1986;77: 12-5.
3. Koenig S, Gendelman HE, Orenstein JM, et al. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 1986;233:1089-93.
4. Tschachler E, Groh V, Popovic M, et al. Epidermal Langherans cells - a target for HTLV-III/LAV infection. J Invest Dermatol 1987;88:233-7.
5. Armstrong JA, Home P. Follicular dendritic cells and virus-like particles in AIDS-related lymphoadenopathy. Lancet 1984;2: 370-2.
6. Salahuddin BSZ, Rose RM, Groopman JE, Markham PD, Gallo RC. Human T lymphotropic virus type III infection of human alveolar macrophages. Blood 1986;68:281-4.
7. Perno CF, Yarchoan R, Cooney DA, et al. Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/ macrophages by azidothymidine and related 2′,3′-dideoxynucleosides. J Exp Med 1988;168:1111-25.
8. Richman DD, Kornbluth RS, Carson DA. Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. J Exp Med 1987;166:1144-9.
9. Gao W, Cara A, Gallo R, Lori F. Low levels deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication. Proc Natl Acad Sci USA 1993;90:8925-8.
10. Gao W, Agbaria R, Driscoll JS, Mitsuja H. Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2′,3′-dideoxynucleoside analogs in resting and activated human cells. J Biol Chem 1994;269:12633-8.
11. Perno CF, Yarchoan R, Cooney DA, et al. Replication of human immunodeficiency in monocytes. J Exp Med 1989;169:933-51.
12. Magnani M, Rossi L, Brandi G, Schiavano GF, Montroni M, Piedimonte G. Targeting antiretroviral nucleoside analogues in phosphorylated form to macrophages: in vitro and in vivo studies. Proc Natl Acad Sci USA 1992;89:6477-81.
13. Magnani M, Rossi L, Fraternale A, et al. Feline immunodeficiency virus infection of macrophages: in vitro and in vivo inhibition by dideoxycytidine-5′-triphosphate-loaded erythrocytes. AIDS Res Hum Retrovirol 1994;10:1179-85.
14. Rossi L, Brandi G, Fraternale A, Schiavano GF, Chiarantini L, Magnani M. Inhibition of murine retrovirus-induced immunodeficiency disease by dideoxycytidine and dideoxycytidine-5′-triphosphate. J Acquir Immune Defic Syndr Hum Retrovirol 1993; 6:1179-86.
15. Magnani M, Casabianca A, Rossi L, et al. Inhibition of HIV-1 and LP-BM5 replication in macrophages by dideoxycytidine and dideoxycytidine-5′-triphosphate. Antiviral Chem Chemother 1995; 6:312-9.
16. Magnani M, Casabianca A, Fraternale A, et al. Synthesis and targeted delivery of an azidothymidine homodinucleotide conferring protection to macrophages against retroviral infection. Proc Natl Acad Sci USA 1996;93:4403-8.
17. Benatti U, Giovine M, Damonte G, et al. Azidothymidine homodinucleotide-loaded erythrocytes as bioreactors for slow delivery of the antiretroviral drug azidothymidine. Biochem Biophys Res Commun 1996;220:20-5.
18. Hirsch M, D'Aquila RT. Therapy for human immunodeficiency virus infection. N Engl J Med 1993;328:1686-95.
19. Mitsuja H, Yarchoan R, Broder S. Molecular targets for AIDS therapy. Science 1990;249:1533-44.
20. Jacobson MA, Van Der Horst C, Consey DM, Dehlinger M, Hafner R, Mills J. In vivo additive antiretroviral effect of combined zidovudine and foscarnet therapy for human immunodeficiency virus infection (ACTG protocol 053). J Infect Dis 1991;163:1219-22.
21. Yarchoan R, Lietzau JA, Nguyen BY, et al. A randomized pilot study of alternating or simultaneous zidovudine and didanosine therapy in patients with symptomatic human immunodeficiency virus infection. J Infect Dis 1994;169:9-17.
22. Mosier DE, Yetter RA, Morse HC III. Functional T lymphocytes are required for a murine retrovirus induced immunodeficiency disease (MAIDS). J Exp Med 1987;165:1737-42.
23. Fraternale A, Casabianca A, Rossi L, et al. Inhibition of murine AIDS by combination of AZT and dideoxycytidine 5′-triphosphate. J Acquir Immun Defic Syndr Hum Retrovirol 1996; 12:164-73.
24. Chattopadhyay SK, Sengupta DN, Fredrickson TN, Morse HC III, Hartley JW. Characteristics and contributions of defective, ecotropic and mink cell focus-inducing viruses in a retrovirus induced immunodeficiency syndrome of mice. J Virol 1991;65:4232-41.
25. Kurdi-Haidar B, Mason PJ, Berrebi A, et al. Origin and spread of the glucose-6-phosphate dehydrogenase variant (G6PD-mediterranean) in the Middle East. Am J Hum Genet 1990;47: 1013-9.
26. Palamara AT, Garaci E, Rotilio G, et al. Inhibition of murine AIDS by reduced glutathione. J Acquir Immune Def Syndr Hum Retrovirol 1996;12:1373-81.
27. Brandi G, Casabianca A, Schiavano GF, et al. Efficacy and toxicity of long-term administration of 2′,3′-dideoxycytidine in the LP-BM5 murine-induced immunodeficiency model. Antiviral Chem Chemother 1995;6:153-61.
28. Gendelman HE, Orenstein JH, Baca LM, et al. The macrophage in the persistence and pathogenesis of HIV infection. AIDS 1989;3: 475-95.
29. Schnittman SM, Psallidopoulus MC, Lane HC, et al. The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4. Science 1989;245:305-8.
30. Zhu T, Mo H, Wang N, et al. Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 1993; 261:1179-81.
31. Hill CM, Littman DR. Natural resistance to HIV? Nature 1996; 382:668-9.
32. Samson M, Frederick L, Doranz BJ, et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant of the CCR-5 chemokine receptor gene. Nature 1996;382:722-5.
33. Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996;86:367-77.
34. Jolicoeur P. Murine acquired immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis. FASEB J 1991;5:2398-405.
35. Morse HC III, Chattopadhyay SK, Makino M, Fredrickson TN, Hugin AW, Hartley JW. Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS. AIDS 1992;6:607-21.
36. Basham T, Rios CD, Holdener T, Merigan TC. Zidovudine (AZT) reduces virus titer, retards immune dysfunction, and prolongs survival in the LP-BM5 murine induced immunodeficiency model. J Infect Dis 1990;161:1006-9.
37. Bilello JA, Kork JJ, MacAuley C, Fredrickson TN, Yetter RA, Eiseman JL. ZDV delays but does not prevent the transmission of MAIDS by LP-BM5 MnLV-infected macrophage-monocytes. J Acquir Immune Defic Syndr Hum Retrovirol 1992;5:571-6.
38. Glass JD, Johnson RT. Human immunodeficiency virus and the brain. Annu Rev Neurosci 1996;19:1-26.