Targeted molecular diversity in drug discovery: Integration of structure-based design and combinatorial chemistry

Drug Discovery Today

Volumn 3, Issue 3, 1998, Pages 105-112

  Li, Jin ^a   Murray, Christopher W ^a   Waszkowycz, Bohdan ^a   Young, Stephen C ^a  

^a Proteus Molecular Design Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR;

COMPUTER AIDED DESIGN; DRUG DESIGN; DRUG RESEARCH; DRUG STRUCTURE; REVIEW;

EID: 0032030723     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(97)01138-0     Document Type: Review

References (33)

1. 1 Gallop, M.A. et al. (1994) J. Med. Chem. 37, 1233-1251
2. 2 Terret, N.K. et al. (1995) Tetrahedron 51, 8135-8173
3. 3 Thompson, L.A. and Ellman, J.A. (1996) Chem. Rev. 96, 555-600
4. 4 Koppel, G. et al. (1995) Chem. Biol. 2, 483-487
5. 5 Murphy, M.M. et al. (1995) J. Am. Chem. Soc. 117, 7029-7030
6. 6 Wang, G.T. et al. (1995) J. Med. Chem. 38, 2995-3002
7. 7 Pirrung, M.C., Chau, J-L. and Chen, J. (1995) Chem. Biol. 2, 621-626
8. 8 Balkenkohl, F. et al. (1996) Angew. Chem., Int. Ed. Engl. 35, 2288-2337
9. 9 DeWitt, S.H. and Czarnik, A.W. (1996) Acc. Chem. Res. 29, 114-122
10. 10 Carell, T. et al. (1995) Chem. Biol. 2, 171-183
11. 11 Martin, E.J. et al. (1995) J. Med. Chem. 38, 1431-1436
12. 12 Brown, R.D. and Martin, Y.C. (1996) J. Chem. Inf. Comput. Sci. 36, 572-584
13. 13 Martin, E.J. et al. (1997) in Reviews in Computational Chemistry (Vol. 10) (Lipkowitz, K.B. and Boyd, D.B., eds), pp. 75-100, VCH
14. 14 Ashton, M.J., Jaye, M.C. and Mason, J.S. (1996) Drug Discovery Today 1, 71-78
15. 15 Banner, D.W. and Hadvary, P. (1991) J. Biol. Chem. 266, 20085-20093
16. 16 Kuntz, I.D. (1992) Science 257, 1078-1083
17. 17 Bohacek, R.S., McMartin, C. and Guida, W.C. (1996) Med. Res. Rev. 16, 3-50
18. 18 DesJarlais, R.L. et al. (1988) J. Med. Chem. 31, 722-729
19. 19 Goodford, P.J. (1985) J. Med. Chem. 28, 849-857
20. 20 Böhm, H-J. (1992) J. Comput.-Aided Mol. Design 6, 61-78
21. 21 Murray, C.W. et al. (1997) J. Comput.-Aided Mol. Design 11, 193-207
22. 22 Kick, E.K. et al. (1997) Chem. Biol. 4, 297-307
23. 23 Available Chemicals Directory (1995) MDL Information Systems Inc.
24. 24 Eldridge, M.D. et al. (1997) J. Comput.-Aided Mol. Design 11, 425-445
25. 25 Böhm, H-J. (1994) J. Comput.-Aided Mol. Design 8, 243-256
26. 26 Baldwin, E.T. et al. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6796-6800
27. 27 Meng, E.C., Shoichet, B.K. and Kuntz, I.D. (1996) J. Comput. Chem. 13, 505-524
28. 28 Sheridan, R.P. and Kearsley, S.K. (1995) J. Chem. Inf. Comput. Sci. 35, 310-320
29. 29 Weber, L. et al. (1995) Angew. Chem., Int. Ed. Engl. 34, 2280-2282
30. 30 Singh, J. et al. (1996) J. Am. Chem. Soc. 118, 1669-1676
31. 31 Salemme, F.R., Spurlino, J. and Bone, R. (1997) Structure 5, 319-324
32. 32 Zheng, Q. and Kyle, D.J. (1997) Drug Discovery Today 2, 229-234
33. 33 Rockwell, A. et al. (1996) J. Am. Chem. Soc. 118, 10337-10338