Identification of core structure and critical T cell receptor contact residues in an antigenic peptide by measuring acidification rates

Journal of Immunological Methods

Volumn 212, Issue 1, 1998, Pages 49-59

  Arimilli, Subhashini ^b   Deshpande, Shrikant V ^b   Nag, Bishwajit ^a,b  

^a NATPRO   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Acidification rates; MHC peptide; Microphysiometer; T cell stimulation; TCR interaction

Indexed keywords

ALANINE; ANTIGEN; GAMMA INTERFERON; LYMPHOTOXIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN BASIC PROTEIN; SILICON; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR;

ACIDIFICATION; AMINO TERMINAL SEQUENCE; ARTICLE; BIOSENSOR; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HERPES VIRUS SAIMIRI; HUMAN; HUMAN CELL; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR OCCUPANCY; T LYMPHOCYTE; VIRUS CELL TRANSFORMATION;

AMINO ACID SEQUENCE; BINDING SITES; BIOSENSING TECHNIQUES; CLONE CELLS; EPITOPE MAPPING; HUMANS; HYDROGEN-ION CONCENTRATION; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

HERPES; HERPESVIRIDAE; SAIMIRI; SAIMIRIINE HERPESVIRUS 2;

EID: 0032029832     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(98)00010-6     Document Type: Article

References (22)

1. Allen, I.V., 1991. Pathology of multiple sclerosis. In: Matthews, W.B., Acheson, E.D., Batchelor, J.R., Weller, R.O. (Eds.), McAlpine's Multiple Sclerosis. Livingstone, Edinburgh, p. 341.
2. Arimilli, S., Cardosa, C., Mukku, P., Baichwal, V., Nag, B., 1995. Refolding and reconstitution of functionally active complexes of human leukocyte antigen DR2 and myelin basic protein peptide from recombinant alpha and beta polypeptide chains. J. Biol. Chem. 270, 971.
3. Evavold, B.D., Sloan-Lancaster, J., Allen, P.M., 1993. Tickling the TCR: selective T-cell functions stimulated by altered 7 peptide ligands. Immunol. Today 14, 602.
4. Kersh, G.J., Allen, P.M., 1996. Essential flexibility in the T cell recognition of antigen. Nature 380, 495.
5. Luu, T., Pham, S., Deshpande, S., 1996. Automated multiple peptide synthesis: Improvements in obtaining quality peptides. Int. J. Pept. Protein Res. 47, 91.
6. Martin, R., McFarland, H.F., McFarlin, D.E., 1992a. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 10, 153.
7. Martin, R., Utz, U., Coligan, J.E., Kichert, J.R., Flerlage, M., Robinson, E., Stone, R., Biddison, W.E., McFarlin, D.E., McFarland, H.F., 1992b. Diversity in fine specificity and T cell receptor usage of the human CD4 + cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106. J. Immunol. 148, 1359.
8. McConnell, H.M., Owicki, J.C., Parce, J.W., Miller, D.L., Baxter, G.T., Wada, G., Pitchford, S., 1992. The cytosensor microphysiometer: biological applications of silicon technology. Science 257, 1906.
9. McConnell, H.M., Wada, H.G., Arimilli, S., Fok, K.S., Nag, B., 1995. Stimulation of T cells by antigen-presenting cells is kinetically controlled by antigenic peptide binding to major histocompatibility complex class II molecules. Proc. Natl. Acad. Sci. USA 92, 2750.
10. Mukku, P.V., Passmore, D., Phan, D., Nag, B., 1995. pH dependent binding of high and low affinity myelin basic protein peptides to purified HLA-DR2. Mol. Immunol. 32, 555.
11. Nag, B., Wada, H.G., Fok, K.S., Green, D.J., Sharma, S.D., Clark, B.R., Parce, J.W., McConnell, H.M., 1992. Antigen-specific stimulation of T cell extracellular acidification by MHC class II-peptide complexes. J. Immunol. 148, 2040.
12. Nag, B., Wada, H.G., Passmore, D., Clark, B.R., Sharma, S.D., McConnell, H.M., 1993. Purified beta chair of MHC class II binds to CD4 molecules on transfected HeLa cells. J. Immunol. 150, 1358.
13. Parce, J.W., Owicki, J.C., Kercso, K.M., Sigal, G.B., Wada, H.G., Muir, V.C., Bousse, L.J., Ross, K.L., Sikic, B.I., McConnell, H.M., 1989. Detection of cell-affecting agents with a silicon biosensor. Science 246, 243.
14. Rabinowitz, J.D., Beeson, C., Wulfing, C., Tate, K., Allen, P.M., Davis, M.M., McConnell, H.M., 1996. Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity 5, 125.
15. Rammensee, H.G., Friede, T., Stevanovic, S., 1995. MHC ligands and peptide motifs: first listing. Immunogenetics 41, 178.
16. Sloan-Lancaster, J., Allen, P.M., 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14, 1.
17. Vergelli, M., Hemmer, B., Kalbus, M., Vogt, A.B., Ling, N., Conlon, P., Coligan, J.E., McFarland, H., Martin, R., 1997. Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands for autoreactive T cells. J. Immunol. 158, 3746.
18. Vogt, A.B., Kropshofer, H., Kalbacher, H., Kalbus, M., Rammensee, H.G., Coligan, J.E., Martin, R., 1994. Ligand motifs of HLA-DRB5*0101 and DRB1 * 1501 molecules delineated from self-peptides. J. Immunol. 153, 1665.
19. Weber, F., Meinl, E., Drexler, K., Czlonkowska, A., Huber, S., Fickencher, H., Fleckenstein, M., Fleckenstein, B., Wekerle, H., Hohlfeld, R., 1993. Transformation of human T-cell clones by Herpesvirus saimiri: intact antigen recognition by autonomously growing myelin basic protein-specific T cells. Proc. Natl. Acad. Sci. USA 90, 11049.
20. Wucherfenning, K.W., Weiner, H.L., Hafler, D.A., 1991. T-cell recognition of myelin basic protein. Immunol. Today 12, 277.
21. Wucherfenning, K.W., Sette, A., Southwood, S., Oseroff, C., Matsui, M., Strominger, J.L., Hafler, D.A., 1994. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179, 279.
22. Zamvil, S.S., Steinman, L., 1990. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8, 579.