Mucin Glycoproteins in Colonic Neoplasia

Keio Journal of Medicine

Volumn 47, Issue 1, 1998, Pages 10-18

  Kim, Young S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Colorectal cancer; Glycosylation; Mucin; Selectin

Indexed keywords

MUCIN; TUMOR PROTEIN;

CHEMISTRY; COLON TUMOR; HUMAN; REVIEW;

COLONIC NEOPLASMS; HUMANS; MUCINS; NEOPLASM PROTEINS;

EID: 0032016297     PISSN: 00229717     EISSN: None     Source Type: Journal    
DOI: 10.2302/kjm.47.10     Document Type: Review

References (54)

1. Kim YS, Gum JR, Brockhausen I: Mucin glycoproteins in neoplasia. Glycoconjate J 1996; 13: 693-707
2. Hakomori SI: Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism. Cancer Res 1996; 56: 5309-5318
3. Fukuda M: Possible roles of tumor-associated carbohydrate antigens. Cancer Res 1996; 56: 2237-2244
4. Kim YJ, Varki A: Perspectives on the significance of altered glycosylation of glycoproteins in cancer. Glycoconjugate J 1997 (in press)
5. Jass JR, Roberton AM: Colorectal mucin histochemistry in health and disease: a critical review. Path Int 1994; 44: 487-504
6. Devine PL, McKenzie IF: Mucins: structure, function, and associations with malignancy. Bioessays 1992; 146: 619-625
7. Kim YS: Mucin glycoproteins in gastrointestinal malignancy and metastasis. Eur J Gastroenterol Hepatol 1993; 5: 219-225
8. Sawada R, Lowe JB, Fukuda M: E-selectin dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels. J Biol Chem 1993; 268: 12675-12681
9. Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani EN, Wilson D: Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J Biol Chem 1990; 265: 15286-15293
10. Ligtenberg MJ, Vos HL, Gennissen AM, Hilkens J: Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini. J Biol Chem 1990; 265: 5573-5578
11. Lan MS, Batra SK, Qi WN, Metzgar RS, Hollingsworth MA: Cloning and sequencing of a human pancreatic tumor mucin cDNA. J Biol Chem 1990; 265: 15294-15299
12. Gum JR, Byrd JC, Hicks JW, Toribara NW, Lamport DT, Kim YS: Molecular cloning of human intestinal mucin cDNAs: Sequence analysis and evidence for genetic polymorphism. J Biol Chem 1989; 264: 6480-6487
13. Gum JR, Hicks JW, Swallow DM, Lagace RE, Byrd JC, Lamport DT, Siddiki B, Kim YS: Molecular cloning of cDNAs derived from a novel human intestinal mucin gene. Biochem Biophys Res Commun 1990; 171: 407-415
14. Aubert JP, Porchet N, Crepin M, Duterque-Coquillaud M, Vergnes G, Mazzuca M, Debuire B, Pretiprez D, Degand P: Evidence for different human tracheobronchial mucin peptides deduced from nucleotide cDNA sequences. Am J Respir Cell Mol Biol 1991; 5: 178-185
15. Porchet N, Nguyen VC, Dufosse J, Audie JP, Guyonnet-Duperat V, Gross MS, Denis C, Degard P, Bernheim A, Aubert JP: Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs. Biochem Biophys Res Commun 1991; 175: 414-422
16. Meezaman D, Charles P, Daskal E, Polymeropoulos MH, Martin BM, Rose MC: Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). J Biol Chem 1994; 269: 12932-12939
17. Lesuffleur T, Roche F, Hill AS, Lacasa M, Fox M, Swallow DM, Zweibaum A, Real FX: Characterization of a mucin cDNA clone isolated from HT-29 mucus-secreting cells: the 3'end of MUC5AC? J Biol Chem 1995; 270: 13665-13673
18. Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N: Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes? Biochem J 1995; 305: 211-219
19. Ho SB, Roberton AM, Shekels LL, Lyftogt CT, Niehans GA, Toribara NW: Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression. Gastroenterology 1995; 109: 735-747
20. Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, Gum JR, Byrd JC, Siddiki B, Kim YS: Human gastric mucin: Identification of a unique species by expression cloning. J Biol Chem 1993; 268: 5879-5885
21. Hutchins JT, Reading CL, Giavazzi R, Hoaglund J, Jessup JM: Distribution of mono-, di-, and tri-O-acetylated sialic acids in normal and neoplastic colon. Cancer Res 1988; 48: 483-489
22. Ogata S, Ho I, Chen A, Dubois D, Maklansky J, Singhal A, Hakomori S, Itzkowitz SH: Tumor-associated sialylated antigens are constitutively expressed in normal human colonic mucosa. Cancer Res 1995; 55: 1869-1874
23. (x) contributes to its over-expression in colon carcinoma metastasis. Int J Cancer 1997; 72: 258-264
24. Yang JM, Byrd JC, Siddiki BB, Chung YS, Okuno M, Sowa M, Kim YS, Matta KL, Brockhausen I: Alterations of O-glycan biosynthesis in human colon cancer tissues. Glycobiology 1994; 4: 873-884
25. Itzkowitz SH, Yuan M, Montgomery CK, Kjeldsen T, Takahashi HK, Bigbee WL, Kim YS: Expression of Tn, sialosyl Tn, and T antigens in human colon cancer. Cancer Res 1989; 49: 197-204
26. Itzkowitz SH, Bloom EJ, Lau TS, Kim YS: Mucin-associated Tn and Sialosyl-Tn antigen expression in colorectal polyps. Gut 1992; 33: 518-523
27. Singhal A, Fohn M, Hakomori S: Induction of α-N-acetylgalactosamine-O-serine/threonine(Tn) antigen-mediated cellular immune response for active immunotherapy in mice. Cancer Res 1991; 51: 1406-1411
28. Springer GF, Desai PR, Tegtmeyer H, Spencer BD, Scanlon EF: Pancarcinoma T/Tn antigen detects human carcinoma long before biopsy does and its vaccine prevents breast carcinoma recurrence. Ann NY Acad Sci 1993; 690: 355-357
29. Fung PY, Madej M, Koganty RR, Longenecker BM: Specific immunotherapy of a murine mammary adenocarcinoma using a synthetic tumor-associated glycoconjugate. Cancer Res 1990; 50: 4308-4314
30. O'Boyle KP, Zamore R, Adluri S, Cohen A, Kemeny N, Welt S, Lloyd KO, Oettgen HF, Old LJ, Livingston PO: Immunization of colorectal cancer patients with modified ovine submaxillary gland mucin and adjuvants induces IgM and IgG antibodies to sialylated Tn. Cancer Res 1992; 52: 5663-5667
31. MacLean GD, Reddish M, Koganty RR, Wong T, Gamdhi S, Smolenski M, Samuel J, Nabholtz JM, Longenecker BM: Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant. Cancer Immunol Immunother 1993; 36: 215-222
32. Holmes EH, Hakomori S, Ostrander GK: Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed β1→3N-acetylglucosaminyltransferase. J Biol Chem 1987; 262: 15649-15658
33. x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion. J Biol Chem 1991; 266: 17467-17477
34. Majuri ML, Niemela R, Tiisala S, Renkonen O, Renkonen R: Expression and function of α2.3-sialyl-and α1.3/1, 4-fucosyltransferases in colon adenocarcinoma cell lines: role in synthesis of E-selectin counter-receptors. Int J Cancer 1995; 63: 551-559
35. x-related antigen expression in human malignant and nonmalignant colonic tissue. Cancer Res 1986; 46: 2627-2632
36. x antigens in human colorectal polyps. J Natl Cancer Inst 1987; 78: 479-488
37. y blood group-related antigens in human malignant, premalignant, and nonmalignant colonic tissues. Cancer Res 1986; 46: 5985-5992
38. y-related cell surface antigens. Cancer Res 1990; 50: 2183-2190
39. Itzkowitz SH, Bloom EJ, Kokal WA, Modin G, Hakomori S, Kim YS: Sialosyl-Tn: A novel mucin antigen associated with prognosis in colorectal cancer patients. Cancer 1990; 66: 1960-1966
40. Yeh MM, Park NH, Duh Q, Montgomery CK, McQuaid KR, Toribara NW, Ho S, Sleisenger MH, Kim YS: Association of colorectal cancer prognosis with expression of mucin core peptides and carbohydrate associated antigens. Gastroenterology 1996; 110: A617
41. x antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. Cancer Res 1993; 53: 3632-3637
42. Ho SB, Niehans GA, Lyftogt C, Yan PS, Cherwitz DL, Gum ET, Dahiya R, Kim YS: Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res 1993; 53: 641-651
43. Ogata S, Uehara H, Chen A, Itzkowitz SH: Mucin gene expression in colonic tissues and cell lines. Cancer Res 1992; 52: 5971-5978
44. Gum JR, Hicks JW, Kim YS: Identification and characterization of the MUC2 (human intestinal mucin) gene 5′-flanking region: promoter activity in cultured cells. Biochem J 1997; 325: 259-267
45. Li JD, Dohrman AF, Gallup M, Miyata S, Gum JR, Kim YS, Nadel JA, Prince A, Basbaum C: Upregulation of mucin transcription by P. aeruginosa LPS in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci USA 1997; 94: 967-972
46. Han SY, Lee MS, Baek SH, Erickson RH, Sleisenger MH, Kim YS: Alterations in mucin gene expression and biological properties of colon cancer cells by protein kinase C activation. Gastroenterology 1997; 112: A575
47. Bresalier RS, Niv Y, Byrd JC, Duh QY, Toribara NW, Rockwell RW, Dahiya R, Kim YS: Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis. J Clin Invest 1991; 87: 1037-1045
48. Schwartz B, Bresalier RS, Kim YS: The role of mucin in colon-cancer metastasis. Int J Cancer 1992; 52: 60-65
49. Bresalier RS, Ho SB, Shoeppner HL, Kim YS, Sleisenger MH, Brodt P, Byrd JC: Enhanced sialylation of mucin-associated carbohydrate structures in human colon cancer metastasis. Gastroenterology 1996; 110: 1354-1367
50. Mannori G, Crottet P, Cecconi O, Hanasaki K, Aruffo A, Nelson RM, Varki A, Bevilacqua MP: Differential colon cell adhesion to E-, P-, and L-selectin: role of mucin-type glycoproteins. Cancer Res 1995; 55: 4425-4431
51. x determinants - a major structural motif in glycans from LS174T HM7 human colon carcinoma mucin. J Biol Chem 1997 (in press)
52. Kojima, N, Handa K, Newman W, Hakomori S: Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells. Biochem Biophys Res Commun 1992; 182: 1288-1295
53. Barnd DL, Lan MS, Metzgar RS, Finn OJ: Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells, Proc Natl Acad Sci USA 1989; 86: 7159-7163
54. Cohen J: Cancer vaccines get a shot in the arm. Science 1993; 262: 841-843