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Hudlicky T, Abboud KA, Entwistle DA, Fan R, Maurya R, Thorpe AJ, Bolonick J, Myers B: Toluene-dioxygenase-mediated cis-dihydroxylation of aromatics in enantioselective synthesis. Iterative glycoconjugate coupling strategy and combinatorial design for the synthesis of oligomers of non-saccharides, inositols and pseudosugars with interesting molecular properties. Synthesis 1996, 897-911.
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Hudlicky T, Tian X, Königsberger K, Maurya R, Rouden J, Fan B: Toluene dioxygenase-mediated cis-dihydroxylation of aromatics in enantioselective synthesis. Asymmetric total syntheses of pancratistatin and 7-deoxypancratistatin, promising antitumor agents. J Am Chem Soc 1996, 118:10752-10765. The first enantioselective synthesis of an important antitumor target is described in detail.
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Synthesis and biological evaluation of aza-C-disaccharides: (1-6), (1-4), and (1-1) linked sugar mimics
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Johns BA, Pan YT, Elbein AD, Johnson CR: Synthesis and biological evaluation of aza-C-disaccharides: (1-6), (1-4), and (1-1) linked sugar mimics. J Am Chem Soc 1997, 119:4856-4865. This paper provides nice examples of how biocatalysis can be incorporated in synthesis to efficiently transform simple starting materials to complex targets, in these cases, bromobenzene to disaccharide mimics.
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Butora G, Hudlicky T, Fearnley S, Gum AG, Stabile MR, Abboud K: Chemoenzymatic synthesis of the morphine skeleton via radical cyclization and a C10-C11 closure. Tetrahedron Lett 1996, 37:8155-8158. Biocatalysis is the key to the rapid assembly of the morphinan skeleton.
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0028823790
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Enzymatic resolution of a C2 symmetric diol derived from p-benzoquinone: Synthesis of (+)- And (-)-bromoxone
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Johnson CR, Miller MW: Enzymatic resolution of a C2 symmetric diol derived from p-benzoquinone: synthesis of (+)- and (-)-bromoxone. J Org Chem 1995, 60:6674-6675.
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Sonogashira coupling of 2-iodo-2-cycloalkenones: Synthesis of (+)- And (-)-harveyone and (-)-tricholomenyn A
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Miller MW, Johnson CR: Sonogashira coupling of 2-iodo-2-cycloalkenones: synthesis of (+)- and (-)-harveyone and (-)-tricholomenyn A. J Org Chem 1997, 62:1582-1583.
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Miller, M.W.1
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Triply convergent synthesis of (-)-prostaglandin E2 methyl ester
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Synthesis of the carbocyclic nucleoside (-)-neplanocin A
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Chemoenzymatic synthesis of 4-substituted riboses. S-(4′-methyladenosyl)-L-homocysteine
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Johnson CR, Esker JL, Van Zandt MC: Chemoenzymatic synthesis of 4-substituted riboses. S-(4′-methyladenosyl)-L-homocysteine. J Org Chem 1994, 59:5854-5855.
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Chemoenzymatic synthesis of trans-4,5-dihydroxycyclopent-2-enones: Conversion to D-1-deoxynojrimycin
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Johnson CR, Nerurkar BM, Golebiowski A, Sundram H, Esker JL: Chemoenzymatic synthesis of trans-4,5-dihydroxycyclopent-2-enones: conversion to D-1-deoxynojrimycin. J Chem Soc Chem Commun 1995, 1139-1140.
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Chemoenzymatic synthesis of a versatile cyclopentenone: (+)-(3aS, 6aS)-2,2-dimethyl-3aβ,6aβ-dihydro-4H-cyclopenta-1,3-dioxol-4-one
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Biadatti T, Esker JL, Johnson CR: Chemoenzymatic synthesis of a versatile cyclopentenone: (+)-(3aS, 6aS)-2,2-dimethyl-3aβ,6aβ-dihydro-4H-cyclopenta-1,3-dioxol-4-one. Tetrahedron - Asymmetry 1996, 7:2313-2320.
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Sugahara T, Ogasawara K: Enantioconvergent synthesis of (+)-estrone from racemic 4-tert-butoxy-2-cyclopentenone. Tetrahedron Lett 1996, 37:7403-7406. This paper illustrates a nice example of biocatalytic resolution combined with a retro Diels-Alder reaction to achieve bioactive targets.
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Enantio- and diastereoselective transformations of cycloheptatriene to sugars and related products
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Building blocks for skipped polyols: Syn-1,3-acetonides by chemoenzymatic synthesis from cycloheptatriene
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