Reduced levels of transforming growth factor β receptor type II in human prostate cancer: An immunohistochemical study

Clinical Cancer Research

Volumn 2, Issue 4, 1996, Pages 635-640

  Williams, Russel H ^a   Stapleton, Alan M F ^a   Yang, Guang ^a   Truong, Luan D ^a   Rogers, Eammon ^a   Timme, Terry L ^a   Wheeler, Thomas M ^a   Scardino, Peter T ^a   Thompson, Timothy C ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; TISSUE LEVEL;

AGED; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PROSTATIC NEOPLASMS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA;

EID: 0029991231     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Roberts, A. B., and Sporn, M. B. The transforming growth factorbeta. In: M. B. Sporn and A. B. Roberts (eds.). Peptide Growth Factors and Their Receptors, pp. 419-472. Heidelberg: Springer-Verlag, 1990.
2. Ruscetti, F. W., and Palladino, M. A. Transforming growth factor β and the immune system. Prog. Growth Factor Res., 53: 159-175, 1991.
3. Heine, U. I., Munoz, E. F., Flanders, K. C., Ellingworth, L. R., Lam, H-Y. P., Thompson, N. L., Roberts, A. B., and Sporn, M. B. Role of transforming growth factor-β in development of mouse embryo. J. Cell Biol., 105: 2861-2876, 1987.
4. Streuli, C., Schmidhauser, C., Kobrin, M., Bissell, M., and Derynck, R. Extracellular matrix regulates expression of the TGF-β1 gene. J. Cell Biol., 120: 253-260, 1993.
5. Wilding, G., Zugmeier, G., Knabbe, C , Flanders, K., and Gelmann, E. Differential effects of transforming growth factor TGF-β on human prostate cell m vitro. Mol. Cell. Endocrinol., 62: 79-87, 1989.
6. Wallenberg, G. K., Semple, E., Quinn, B. A., and Hayes. M. A. Inhibition of proliferation of normal, preneoplastic and neoplastic rat hepatocytes by transforming growth factor-β. Cancer Res., 47: 6595-6599, 1987.
7. Levine, A. E., and Lewis L. R. Transforming growth factor-beta 2 is an autocrine growth inhibitory factor for the Moser human colon carcinoma cell line. Cancer Lett., 68: 33-41, 1993.
8. Yanagihara, K., and Tsumuraya, M. Transforming growth factor beta 1 induces apoptotic cell death in cultured human gastric carcinoma cells. Cancer Res., 52: 4042-4045, 1992.
9. Ito, M., Yasui, W., Kyo, E., Yokozaki, H., Nakayama, H., Ito, H., and Tahara, E. Growth inhibition of transforming growth factor beta on human gastric carcinoma cells: receptor and post receptor signaling. Cancer Res., 2: 295-300, 1992.
10. INK4B is a potent effector of TGF-β-induced cell cycle arrest. Nature (Lond.), 371: 257-261, 1994.
11. 1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-β. Science (Washington DC), 260: 536-539, 1993.
12. Ewen, M. E., Shoss, H. K., Whitehouse, L. L., and Livingston, D. M. TGF-β inhibition of cdk4 synthesis is linked to cell cycle arrest. Cell, 74: 1009-1020, 1993.
13. Kehrl, J. H. Transforming growth factor-β: an important mediator of immunoregulation. Int. J. Cell Cloning. 9: 438-450, 1991
14. Wahl, S. M., McCartney-Francis, N., and Mergenhager, S. E. Inflammatory and immunoregulatory roles of TGF-β. Immunol. Today, 10: 258-261, 1989.
15. Ellinsworth, J., Schmidt, A., Hall, G., Roberts, A. B.. and Sporn, M. B. Transforming growth factor-β is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation. J. Immunol. 140, 3026-3030, 1988.
16. Ruscetti, F. W., and Palladino, M. A. Transforming growth factor-β and the immune system. Prog. Growth Factor Res., 3. 159-175, 1991.
17. Kehrl, J. H., Wakefield, L. M., Roberts, A. B., Jakowlew, S., Alvarez-Mon, M., Derynck, R., and Sporn, M. B. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth J. Exp. Med, 163: 1037-1050, 1986.
18. Yang, E. Y., and Moses, H. L. Transforming growth factor-β1 induces changes on cell migration, proliferation and angiogenesis in the chicken chorioallantoic membrane. J. Cell Biol., 111: 731-741, 1990.
19. Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Hewe, U. I., Liorta, L. A., Falanga. V., Kehrl, J. H., and Fauci, A. S. Transforming growth factor type: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl. Acad. Sci. USA, 83: 4167-4171, 1986
20. Myrdal, S. E., Twarzdzik, D. R., and Auersperg, N. Cell mediated coaction of transforming growth factors: incubation of type β with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type α. J. Cell Biol., 102: 1230-1234, 1986.
21. Samuel, S. K., Hurta, R. A. R., Kondaiah, P., Khalil, H., Turley, E. A., Wright, J. A., and Greenberg. A. H. Autocrine induction of tumor protease production and invasion by a metallothionein-regulated TGF-β1. EMBO J., 11: 1599-1605, 1992.
22. Derynck, R., Goeddel, D. V., Ullnch, A., Gutterman, I. U., Williams, R. D., Bringman, T. S., and Berger, W. H. Synthesis of mRNAs for transforming growth factors α. and β and the epidermal growth factor receptor by human tumors. Cancer Res., 47: 707-712, 1987.
23. Gomella, L. G , Sargent, E. R., Wade, T. P., Angland, P., Linehan, W. M., and Kasid. A. Expression of transforming growth factor α in normal human adult kidney and enhanced expression of transforming growth factors α and β in renal cell carcinoma. Cancer Res., 49: 6972-6975, 1989.
24. Barrett-Lee, P., Travers, M., Lugmani, Y., and Coombes, R. C. Transcripts for transforming growth factors in human breast cancer: clinical correlates. Br. J. Cancer, 61: 612-617, 1990.
25. Ito, N., Kawata, S., Tamora, S., Takaishi, K., Shirai, Y , Kiso, S., Yabeurchi, I., Matsuda, Y., Nishioka, M., and Tarui, S. Elevated levels of transforming growth factor β messenger RNA and its polypeptide in human hepatocellular carcinoma. Cancer Res., 51: 4080-4083, 1991.
26. Thompson, T. C. Growth factors and oncogenes in prostate cancer. Cancer Cells. 2: 345-354, 1990.
27. Merz, V. W., Miller, F J., Krebs, T., Timme, T. L., Kadmon, D., Park, S. H., Egawa, S., Scardino, P. T., and Thompson, T. C. Elevated transforming growth factor β1 and β3 mRNA levels are associated with ras + myc-induced carcinoma in reconstituted mouse prostate: evidence for a paracrine role during progression. Mol. Endocrinol., 5: 503-513, 1991.
28. Truong, L. D., Kadmon, D., McCune, B. K., Kathleen, C. F., Scardino, P. T., and Thompson, T. C. Association of transforming growth factor-β1 with prostate cancer: an immunohistochemical study. Hum. Pathol., 24: 4-9, 1993.
29. Eastham, J. A., Truong. L D. Rogers, E., Kattan, M., Flanders, K. C., Scardino, P. T., and Thompson, T. C. Transforming growth factor-B1: comparative immunohistochemical localization in human primary and metastatic prostate cancer. Lab Invest, 73: 628-635, 1995.
30. Merz, V. W., Arnold, A. M., and Studer, U. E. Differential expression of transforming growth factor-beta 1 and beta 3 as well as c-fos mRNA in normal human prostate, benign prostatic hyperplasia and prostatic cancer. World J. Urol., 12: 96-8, 1994.
31. Lin, H. Y., Wang, X., Ng-Eaton, E., Weinberg, R. A., and Lodish, H. F. Expression cloning of the TGF-β type LI receptor, a functional transmembrane senne/threonine kinase. Cell, 68 775-785, 1992.
32. Wrana, J. L., Attisano, L., Wieser, R., Ventura, F., and Massague, J. Mechanism of activation of the TGF-β receptor. Nature (Lond.), 670: 341-347, 1994
33. Carcamo, J., Zentella, A., and Massagué, J. Disruption of transforming growth factor âsignaling by a mutation that prevents transphosphorylation within the receptor complex. Mol. Cell. Biol., 15: 1573-1581, 1995.
34. Zhou, G. K., Sechrist, G. L., Pereycesany, S., Brattain, M. G., and Mulcher, K. M. Transforming growth factor β isoform-specific differences in interactions with type I and II transforming growth factor β receptors Cancer Res., 55: 2056-2062, 1995.
35. Boyd, F. T., and Massagué, J. Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53 kDa membrane receptor. J. Biol. Chem., 264: 2272-2278, 1989.
36. Laiho, M . Weis, M. B., and Massagué, J. Concomitant loss of transforming growth factor (TGF)-β receptor types I and II in TGF-β resistant cell mutants implicates both receptor types in sianal transduction. J. Biol. Chem., 265. 18518-18524, 1990.
37. Laiho, M., Weis, M. B., Boyd, F. T., Ignotz, R. A., and Massague, J. Responsiveness to transforming growth factor-β (TGF-β) restored by genetic complementation between cells defective in the TGF-β receptors I and II. J. Biol. Chem., 266: 9108-9112, 1991.
38. Park, K., Kim, S., Bang, Y., Park, J., Kim, N. K., Roberts, A. B., and Sporn, M. B. Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-β. Proc. Natl. Acad. Sci. USA. 91: 8772-8776, 1994.
39. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Seen, L., Lutterbaugh, J., Fon, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., Brattain, M., and Wilson, K. V. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science (Washington DC), 268: 1336-1338, 1995.
40. Sun, L., Wu, G., Wilson, J. K., Zborowska, E., Yang, J., Rajkarunanayake, I., Wang, J., Gentry, L. E., Wang, X. F., and Brattain, M. G. Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. J. Biol. Chem , 269: 26449-26455, 1994.
41. Thompson, T. C., Timme, T. L., Hall, S. J., and Stapleton, A. M. F. Perspectives on the molecular biology of prostate cancer. In: N. J. Vogetzang, P. T. Scardino, W. U. Shipley, and D. S. Coffey (eds.), Comprehensive Textbook of Genitourinary Oncology, pp. 593-599. Baltimore: Willliams & Wilkins. 1995.
42. Carruba, G., Leake, R. E., Rinaldi, F., Chalmers, D., Comtto, L., Sorci, C., Davone-Macabers, M., and Castagnetta, L. A. Steroid-growth factor interaction in human prostate cancer. 1. Short-tern effects of transforming growth factors on growth of human prostate cancer cells. Steroids, 59: 412-420, 1994.
43. Steiner, M. S., Zhou, Z. Z., Tonb, D. C., and Barrack E. R. Expression of transforming growth factor-beta 1 in prostate cancer. Endocrinology. 135: 2240-2247, 1994.
44. Brand, T., and Schneider, M. D. Inactive type II and type I receptors for TGFβ are dominant inhibitors of TGFβ-dependent transcription. J. Biol. Chem., 270: 8274-8284, 1995.
45. Shyamal, K. R., and Kole, A. R. Transforming growth factor-β receptor type II expression in the hamster ovary. cellular site(s). biochemical properties, and hormonal regulation. Endocrinology, 136: 4610-4620, 1995.