Use of endogenous carbohydrate and fat as fuels during exercise

Proceedings of the Nutrition Society

Volumn 57, Issue 1, 1998, Pages 49-54

  Martin III, Wade H ^a   Klein, Samuel ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; CARBOHYDRATE METABOLISM; ENERGY METABOLISM; EXERCISE; HUMAN; LIPID METABOLISM; METABOLISM; REVIEW;

ADIPOSE TISSUE; CARBOHYDRATE METABOLISM; ENERGY METABOLISM; EXERCISE; HUMANS; LIPID METABOLISM;

EID: 0031990089     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS19980008     Document Type: Article

References (52)

1. Andres R, Cader G & Zierler KL (1956) The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state: measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm. Journal of Clinical Investigation 35, 671-682.
2. Arner P, Kriegholm E, Engfeldt P & Bolinder J (1990) Adrenergic regulation of lipolysis in situ at rest and during exercise. Journal of Clinical Investigation 85, 893-898.
3. Bulow J & Madsen J (1976) Adipose-tissue blood flow during prolonged, heavy exercise. Pflügers Archives 363, 231-234.
4. Bulow J & Madsen J (1981) Influence of blood flow on fatty acid mobilization from lipolytically active tissue. Pflügers Archives 390, 169-174.
5. Coggan AC (1991) Plasma glucose metabolism during exercise. Sports Medicine 11, 102-124.
6. Coppack SW, Jensen MD & Miles JM (1994) In vivo regulation of lipolysis in humans. Journal of Lipid Research 35, 177-193.
7. Coyle EF, Coggan AR, Hemmert MK & Ivy JL (1986) Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. Journal of Applied Physiology 61, 165-172.
8. Elayan IM & Winder WW (1991) Effect of glucose infusion on muscle malonyl-CoA during exercise. Journal of Applied Physiology 70, 1495-1499.
9. Essen B (1997) Intramuscular substrate utilization during prolonged exercise. Annals of New York Academy of Sciences 301, 30-44.
10. Froberg SO & Mossfeldt F (1971) Effect of prolonged strenuous exercise on the concentration of triglycerides, phospholipids, and glycogen in muscles of man. Acta Physiologica Scandinavica 82, 167-171.
11. Galbo H (1983) Hormonal and Metabolic Adaptations to Exercise. New York: Thieme-Statton.
12. Henriksson J (1977) Training induced adaptation of skeletal muscle and metabolism during submaximal exercise. Journal of Physiology 270, 661-675.
13. Hodgetts V, Coppack SW, Frayn KN & Hockaday TDR (1976) Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. Journal of Applied Physiology 71, 445-451.
14. Holloszy JO & Booth FW (1976) Biochemical adaptations to endurance exercise in muscle. Annual Review of Physiology 38, 273-291.
15. Holloszy JO & Coyle EF (1984) Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. Journal of Applied Physiology 56, 831-839.
16. Hurley BF, Nemeth PM, Martin WH, Hagberg JM, Dalsky GP & Holloszy JO (1986) Muscle triglyceride utilization during exercise: effect of training. Journal of Applied Physiology 60, 562-567.
17. Issekutz BJ, Miller HI, Paul P & Rodahl M (1964) Source of fat oxidation in exercising dogs. American Journal of Physiology 207, 583-587.
18. Jansson E & Kaijser L (1987) Substrate utilization and enzymes in skeletal muscle of extremely endurance-trained men. Journal of Applied Physiology 62, 999-1005.
19. Jones NL, Heigenhauser GJF, Kuksis A, Matsos OG, Sutton JR & Toews CJ (1980) Fat metabolism in heavy exercise. Clinical Science 59, 469-478.
20. Kanaley JA, Cryer PE & Jensen MD (1993) Fatty acid kinetic responses to exercise. Effects of obesity, body fat distribution, and energy-restricted diet. Journal of Clinical Investigation 92, 255-261.
21. Kiens B, Essen-Gustavsson B, Christensen NJ & Saltin B (1993) Skeletal muscle substrate utilization during submaximal exercise in man: Effect of endurance training. Journal of Physiology 469, 459-478.
22. Kiens B & Lithell H (1989) Lipoprotein metabolism influenced by training-induced changes in human skeletal muscle. Journal of Clinical Investigation 83, 558-564.
23. Klein S, Coyle EF & Wolfe RR (1994) Fat metabolism during low-intensity exercise in endurance trained and untrained men. American Journal of Physiology 267, E934-E940.
24. Klein S, Coyle EF & Wolfe RR (1995) Effect of exercise on lipolytic sensitivity in endurance-trained athletes. Journal of Applied Physiology 78, 2201-2206.
25. Klein S, Peters EJ, Holland OB & Wolfe RR (1989) Effect of short- and long-term β-adrenergic blockade on lipolysis during fasting in humans. American Journal of Physiology 257, E65-E73.
26. Klein S, Sakurai Y, Romijn JA & Carroll RM (1993) Progressive alterations in lipid and glucose metabolism during short-term fasting in humans. American Journal of Physiology 265, E801-E806.
27. Klein S, Weber JM, Coyle EF & Wolfe RR (1996) Effect of endurance training on glycerol kinetics during strenuous exercise in humans. Metabolism 45, 357-361.
28. Kjaer M, Christensen NJ, Sonne B, Richter EA & Galbo H (1985) Effect of exercise on epinephrine turnover in trained and untrained male subjects. Journal of Applied Physiology 59, 1061-1067.
29. McGarry JD, Mills SE, Long CS & Foster DW (1983) Observations on the affinity for carnitine and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Biochemical Journal 214, 21-28.
30. Mackie BG, Dudley GA, Kaciuba-Uscilko H & Terjung RL (1980) Uptake of chylomicron triglycerides by contracting skeletal muscle in rats. Journal of Applied Physiology 49, 851-855.
31. Mackie BG & Terjung RL (1983) Blood flow to different skeletal muscle fiber types during contractions. American Journal of Physiology 245, H264-H275.
32. Martin WHI, Dalsky GP, Hurley BF, Matthews DE, Bier DM, Hagberg JM, Rogers MA, King DS & Holloszy JO (1993) Effect of endurance training on plasma free fatty acid turnover and oxidation during exercise. American Journal of Physiology 265, E708-E714.
33. Mendenhall LA, Swanson SC, Habash DL & Coggan AR (1994) Ten days of exercise training reduces glucose production and utilization during moderate-intensity exercise. American Journal of Physiology 266, E136-E143.
34. Newsholme EA & Leech AR (1994) Biochemistry for the Medical Sciences. Chichester: John Wiley and Sons.
35. Phillips SM, Green HJ, Tarnapolsky MA, Heigenhauser GJF, Hill RE & Grant SM (1996) Effects of training duration on substrate turnover and oxidation during exercise. Journal of Applied Physiology 81, 2182-2191.
36. Rebuffe-Scrive M, Andersson B, Olbe L & Bjorntorp P (1989) Metabolism of adipose tissue in intraabdominal depots of nonobese men and women. Metabolism 38, 453-458.
37. Reitman J, Baldwin KM & Holloszy JO (1973) Intramuscular triglyceride utilization by red, white, and intermediate skeletal muscle and heart during exhausting exercise. Proceedings for the Society of Experimental Biology and Medicine 142, 628-631.
38. Roberts TJ, Weber J-M, Hoppeler H, Weibel ER & Taylor CR (1996) Design of the oxygen and substrate pathways. II. Defining the upper limits of carbohydrate and fat oxidation. Journal of Experimental Biology 199, 1651-1658.
39. Robinson IN & Zammit VA (1982) Sensitivity of carnitine acyltransferase I to malonyl-CoA and related compounds with mitochondria from different rat tissues. Biochemical Journal 206, 177-179.
40. Romijn JA, Coyle EF, Sidossis L, Gastaldelli A, Horowitz JF, Endert E & Wolfe RR (1993) Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity. American Journal of Physiology 265, E380-E391.
41. Romijn JA, Coyle EF, Zhang X-J, Sidossis LS & Wolfe RR (1995) Fat oxidation is impaired somewhat during high-intensity exercise by limited plasma FFA mobilization. Journal of Applied Physiology 79, 1939-1945.
42. Ryan WG & Schwartz TB (1965) Dynamics of plasma triglyceride turnover in man. Metabolism 14, 1243-1254.
43. Saddik M, Gamble J, Witters LA & Lopaschuk GD (1993) Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. Journal of Biological Chemistry 268, 25836-25845.
44. Sial S, Coggan AR, Carroll R, Goodwin J & Klein S (1996) Fat and carbohydrate metabolism during exercise in elderly and young subjects. American Journal of Physiology 271, E983-E989.
45. Sidossis LS, Gastaldelli A, Klein S & Wolfe RR (1997) Regulation of plasma fatty acid oxidation during low- and high-intensity exercise. American Journal of Physiology 272, E1065-E1070.
46. Spector AA (1975) Fatty acid binding to plasma albumin. Journal of Lipid Research 16, 165-179.
47. Stallknecht B, Simonsen L, Bulow J, Vinten J & Galbo H (1995) Effect of training on epinephrine-stimulated lipolysis determined by microdialysis in human adipose tissue. American Journal of Physiology 269, E1059-E1066.
48. Turcotte LP, Richter EA & Kiens B (1992) Increased plasma FFA uptake and oxidation during prolonged exercise in trained vs. untrained humans. American Journal of Physiology 262, E791-E799.
49. Wahrenberg H, Lonnqvist F & Arner P (1989) Mechanisms underlying regional differences in lipolysis in human adipose tissue. Journal of Clinical Investigation 84, 458-467.
50. Winder WW, Hickson RC, Hagberg JM, Ehsani AA & McLane JA (1979) Training-induced changes in hormonal and metabolic responses to submaximal exercise. Journal of Applied Physiology 46, 766-771.
51. Wolfe RR, Klein S, Carraro F & Weber JM (1990) Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise. American Journal of Physiology 258, E382-E389.
52. Wolfe RR, Shaw JH & Durkot MJ (1985) Effect of sepsis on VLDL kinetics: responses in basal state and during glucose infusion. American Journal of Physiology 248, E732-E740.