Oxidized heme proteins in an animal model of hemochromatosis

Free Radical Biology and Medicine

Volumn 24, Issue 2, 1998, Pages 239-244

  Brown, Kyle E ^a,b   Knudsen, Christie A ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hemichrome; Iron overload; Lipid peroxidation; Oxidative stress; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; HEMOPROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; HEMOCHROMATOSIS; IRON OVERLOAD; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPECTROSCOPY; VITAMIN INTAKE;

ANIMALS; DIET; DISEASE MODELS, ANIMAL; HEMEPROTEINS; HEMOCHROMATOSIS; IRON; KINETICS; LIVER; MALE; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN E;

ANIMALIA;

EID: 0031984838     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(97)00225-6     Document Type: Article

References (25)

1. Bacon B. R., Brown K. E. Iron metabolism and disorders of iron overload. Kaplowitz N. Liver and biliary diseases. 1996;349-362 Williams and Wilkins, Baltimore.
2. Bacon B. R., Britton R. S. The pathology of hepatic iron overload: A free radical-mediated process? Hepatology. 11:1990;127-137.
3. Bacon B. R., Tavill A. S., Brittenham G. M., Park C. H., Recknagel R. O. Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J. Clin. Invest. 71:1983;429-439.
4. Bacon B. R., Britton R. S. Hepatic injury in chronic iron overload: Role of lipid peroxidation. Chem. Biol. Interact. 70:1989;183-226.
5. Winterbourne C. C. Oxidative reactions of hemoglobin. Packer L., Glazer A. N. Methods in enzymology. 186:1990;265-272 Academic Press, New York.
6. Rachmilewitz E. Denaturation of the normal and abnormal hemoglobin molecule. Semin. Hematol. 11:1974;441-462.
7. Boyle R. C., Tappel A. L., Tappel A. A., Chen H., Andersen H. J. Quantitation of heme proteins from spectra of mixtures. J. Agric. Food Chem. 42:1994;100-104.
8. Andersen H. J., Chen H., Pellett L. J., Tappel A. L. Ferrous-iron-induced oxidation in chicken liver slices as measured by hemichrome formation and thiobarbituric acid-reactive substances: Effects of dietary vitamin E and β-carotene. Free Radic. Biol. Med. 15:1993;37-48.
9. Park C. H., Bacon B. R., Brittenham G. M., Tavill A. S. Pathology of dietary carbonyl iron overload in rats. Lab. Invest. 57:1987;555-563.
10. Dabbagh A., Mannion T., Lynch S. M., Frei B. The effect of iron overload on rat plasma and liver oxidant status in vivo. Biochem. J. 300:1994;799-803.
11. Brown K. E., Poulos J. E., Li L., Soweid A. M., Ramm G. A., O'Neill R., Britton R. S., Bacon B. R. The effect of vitamin E supplementation on hepatic fibrogenesis in chronic dietary iron overload. Am. J. Phys. 272:1997;G116-G123.
12. Torrance J. D., Bothwell T. H. J. Tissue iron stores. Cook J. Iron. 1980;90-115 Churchill Livingstone, New York.
13. Mostow N. D., O'Neill R., Noon D. L., Bacon B. R. Determination of α-tocopherol in rat liver by high performance liquid chromatography utilizing ultraviolet detection. J. Chromatogr. Biomed. Appl. 344:1985;137-143.
14. Bieri J. G., Tolliver T. J., Catignani G. L. Simultaneous determination of α-tocopherol and retinol in plasma of red blood cells by high pressure liquid chromotography. Am. J. Clin. Nutr. 32:1979;2143-2149.
15. Knudsen C. A., Tappel A. L., North J. A. Multiple antioxidants protect against heme protein and lipid oxidation in kidney tissue. Free Radic. Biol. Med. 20:1996;165-173.
16. Chen H., Tappel A. L. Heme protein oxidation and lipid peroxidation of tissue homogenates induced by halogenated hydrocarbon, hydroperoxide, and transition metals. J. Agric. Food Chem. 41:1993;1362-1367.
17. Chen H., Pellett L. J., Andersen H. J., Tappel A. L. Protection by vitamin E, selenium, and β-carotene against oxidative damage in rat liver slices and homogenate. Free Radic. Biol. Med. 14:1993;473-482.
18. Andersen H. J., Pellett L., Tappel A. L. Hemichrome formation, lipid peroxidation, enzyme inactivation and protein degradation as indexes of oxidative damage in homogenates of chicken kidney and liver. Chem. Biol. Interact. 93:1994;155-169.
19. Chen H., Tappel A. L., Boyle R. C. Oxidation of heme proteins as a measure of oxidative damage to liver tissue slices. Free Radic. Biol. Med. 14:1993;509-517.
20. Hanes D. M., Tappel A. L. Lysosomal hemochromes and digestion of cytochrome c by the lysosomal protease system. Biochim. Biophys. Acta. 245:1971;42-53.
21. Parkilla S., Niemelä O., Britton R. S., Brown K. E., Ylä-Herttuala S., O'Neill R., Bacon B. R. Vitamin E decreases hepatic levels of aldehyde-derived peroxidation products in rats with iron overload. Am. J. Physiol. 270:1996;G376-G384.
22. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N. Engl. J. Med. 328:1993;176-183.
23. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 330:1994;1029-1035.
24. Greenberg E. R., Baron J. A., Tosteson T. D., Freeman D. H., Beck G. J., Bond J. H., Colacchio T. A., Coller J. A., Frankl H. D., Haile R. W., Mandel J. S., Nierenberg D. W., Rothstein R., Snover D. C., Stevens M. M., Summers R. W., van Stolk R. U. A clinical trial of antioxidants to prevent colorectal adenoma. N. Engl. J. Med. 331:1994;141-147.
25. Kushi L. H., Folsom A. R., Prineas R. J., Mink P. J., Wu Y., Bostick R. M. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N. Engl. J. Med. 334:1996;1156-1162.