Free radicals in viral pathogenesis: Molecular mechanisms involving superoxide and NO

Proceedings of the Society for Experimental Biology and Medicine

Volumn 217, Issue 1, 1998, Pages 64-73

  Akaike, Takaaki ^a   Suga, Moritaka ^a   Maeda, Hiroshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; NITRIC OXIDE; SUPEROXIDE;

IMMUNE RESPONSE; NONHUMAN; PATHOGENESIS; SHORT SURVEY; VIRUS CELL INTERACTION; VIRUS INFECTION;

EID: 0031983652     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.3181/00379727-217-44206     Document Type: Short Survey

References (108)

1. Oda T, Akaike T, Hamamoto T, Suzuki F, Hirano T, Maeda H. Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD. Science 244:974-976, 1989.
2. - generation by xanthine oxidase of pathogenesis of influenza virus infection in mice. J Clin Invest 85:739-745, 1990.
3. Maeda H, Akaike T. Oxygen free radicals as pathogenic molecules in viral diseases. Proc Soc Exp Biol Med 198:721-727, 1991.
4. Hennet T, Peterhans E, Stocker R. Alterations in antioxidant defences in lung and liver of mice infected with influenza A virus. J Gen Virol 73:39-46, 1992.
5. Akaike T, Maeda H. Molecular pathogenesis of influenza virus pneumonia: Impacts of proteases, kinins, and oxygen radicals derived from hosts. In: Takishima T, Ed. Basic and Clinical Aspects of Pulmonary Fibrosis. Boca Raton: CRC Press, pp213-227, 1994.
6. Ikeda T, Shimokata K, Daikoku T, Fukatsu T, Tsutsui Y, Nishiyama Y. Pathogenesis of cytomegalovirus-associated pneumonitis in ICR mice: Possible involvement of superoxide radicals. Arch Virol 127:11-24, 1993.
7. Akaike T, Noguchi Y, Ijiri S, Setoguchi K, Suga M, Zheng YM, Dietzschold B, Maeda H. Pathogenesis of influenza virus-induced pneumonia: Involvement of both nitric oxide and oxygen radicals. Proc Natl Acad Sci USA 93:2448-2453, 1996.
8. Schwartz KB. Oxidative stress during viral infection: A review. Free Radic Biol Med 21:641-649, 1996.
9. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 329:2002-2012, 1993.
10. Rubbo H, Darley-Usmar V, Freeman BA. Nitric oxide regulation of tissue free radical injury. Chem Res Toxicol 9:809-820, 1996.
11. Schmidt HHHW, Hofmann G, Ogilvie P. Regulation and dysregulation of constitutive nitric oxide synthase types I and III. In: Koprowski H, Maeda H, Eds. The Role of Nitric Oxide in Physiology and Pathophysiology. Berlin, Heidelberg: Springer-Verlag, pp75-86, 1995.
12. Mulligan MS, Hevel JM, Marletta MA, Ward PA. Tissue injury caused by deposition of immune complexes is L-arginine dependent. Proc Natl Acad Sci USA 88:6338-6342, 1991.
13. McCartney-Francis N, Allen JB, Mizel DE, Albina JE, Xie O, Nathan C, Wahl SM. Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 178:749-754, 1993.
14. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265:1883-1885, 1994.
15. Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 262:689-695, 1993.
16. Yoshida M, Akaike T, Wada Y, Sato K, Ikeda K, Ueda S, Maeda H. Therapeutic effect of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity. Biochem Biophys Res Commun 202:923-930, 1994.
17. Nathan CF, Hibbs JB. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 3:65-70, 1991.
18. Badway JA, Karnovsky ML. Active oxygen species and the functions of phagocytic leukocytes. Annu Rev Biochem 49:695-726, 1980.
19. Granger DL, Hibbs JB Jr., Perfect JR, Durack DT. Specific amino acid (L-arginine) requirement for microbiostatic activity of murine macrophages. J Clin Invest 81:1129-1136, 1988.
20. Pryor WA. Free radical biology: Xenobiotics, cancer, and aging. Ann NY Acad Sci 393:1-22, 1982.
21. McCord JM. Free radicals and myocardial ischemia: Overview and outlook. Free Radic Biol Med 4:9-14, 1988.
22. Fridovich I. The biology of oxygen radicals. Science 201:875-880, 1978.
23. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922, 1993.
24. Lafon-Cazal M, Pietri S, Culcasi M, Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature 364:535-537, 1993.
25. 2-dependent type. J Biol Chem 265:14170-14175, 1990.
26. Sidwell RW, Huffman JH, Bailey KW, Wong MH, Nimrod A, Panet A. Inhibitory effects of recombinant manganese superoxide dismutase on influenza virus infections in mice. Antimicrob Agents Chemother 40:2626-2631, 1996.
27. Mosca JD, Bednarik DP, Raj NBK, Rosen CA, Sodroski JG, Haseltine WA, Pitha PM. Herpes simplex virus type-1 can reactive transcription of latent human immunodeficiency virus. Nature 325:67-70, 1987.
28. Kurata S-I. Sensitization of the HIV-1-LTR upon long-term, low-dose oxidative stress. J Biol Chem 271:21798-21802, 1996.
29. Halliwell B, Gutteridge JMC. Oxygen toxicity, oxygen radicals, transition metals, and diseases. Biochem J 219:1-14, 1984.
30. 2 plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme. J Biol Chem 267:25371-25377, 1992.
31. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624, 1990.
32. Pryor WA, Squadrito GL. The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. Am J Physiol 268:L699-L722, 1995.
33. Beckman JS, Koppenol WH. Nitric oxide, superoxide and peroxynitrite: The good, the bad, and the ugly. Am J Physiol 271:C1424-C1437, 1996.
34. Huie RE, Padmaja S. The reaction rate of nitric oxide with superoxide. Free Radic Res Commun 18:195-199, 1993.
35. Asano K, Chee CBE, Gaston B, Lilly CM, Gerard C, Drazen JM, Stamler JS. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc Natl Acad Sci USA 91:10089-10093, 1994.
36. Guo FH, De Raeve H, Rice TW, Stuehr DJ, Thunnissen FBJM, Erzurum SC. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc Natl Acad Sci USA 92:7809-7813, 1995.
37. Merill JE, Ignarro LJ, Sherman MP, Melinek J, Lane TE. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol 151:2132-2141, 1993.
38. Meda L, Cassatella MA, Szendrei GI, Otvos L Jr., Baron P, Villalba M, Ferrari D, Rossi F. Activation of microglia cells by β-amyloid protein and interferon-γ. Nature 374:647-650, 1995.
39. Xie Q, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, Nathan C. Cloning and characterization of nitric oxide synthase from mouse macrophages. Science 256:225-228, 1992.
40. Scott-Burden T, Schini VB, Elisondo E, Junquero DC, Vanhoutte PM. Platelet-derived growth factor suppresses and fibroblast growth factor enhances cytokine-induced production of nitric oxide by cultured smooth muscle cells. Circ Res 71:1088-1100, 1992.
41. Xie Q, Whisnant R, Nathan C. Promoter of the mouse gene encoding calcium-dependent nitric oxide synthase confers inducibility by interferon-γ and bacterial lipopolysaccharide. J Exp Med 177:1779-1784, 1993.
42. De Kimpe SJ, Kengatharan M, Thiemerman C, Vane JR. The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure. Proc Natl Acad Sci USA 92:10359-10363, 1995.
43. Nussler AK, Billiar TR. Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukoc Biol 54:171-178, 1993.
44. Koprowski H, Zheng YM, Heber-Katz E, Frayer N, Rorke L, Fu ZF, Hanlon C, Dietzschold B. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. Proc Natl Acad Sci USA 90:3024-3027, 1993.
45. Zheng YM, Schöfer MKH, Weihe E, Sheng H, Corisdeo S, Fu ZF, Koprowski H, Dietzschold B. Severity of neurological signs and degree of inflammatory lesions in the brains of the rats with Borna disease correlate with the induction of nitric oxide synthase. J Virol 67:5786-5791, 1993.
46. Akaike T, Weihe E, Schaefer M, Fu ZF, Zheng YM, Vogel W, Schmidt H, Koprowski H, Dietzschold B. Effect of neurotropic virus infection on neuronal and inducible nitric oxide synthase activity in rat brain. J Neurovirol 1:118-125, 1995.
47. Mikami S, Kawashima S, Kanazawa K, Hirata K, Katayama Y, Hotta H, Hayashi Y, Ito H, Yokoyama M. Expression of nitric oxide synthase in a murine model of viral myocarditis induced by coxsackie virus B3. Biochem Biophys Res Commun 220:983-989, 1996.
48. Kreil TR, Eibl MM. Nitric oxide and viral infection: No antiviral activity against a flavivirus in vitro, and evidence for contribution to pathogenesis in experimental infection in vivo. Virology 219:304-306, 1996.
49. Bi Z, Barna M, Komatsu T, Reiss CS. Vesicular stomatitis virus infection of the central nervous system activates both innate and acquired immunity. J Virol 69:6466-6472, 1995.
50. Campbell IL, Samimi A, Chiang C-S. Expression of the inducible nitric oxide synthase: Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis. J Immunol 153:3622-3629, 1994.
51. Bukrinsky MI, Nottet HSLM, Schmidtmayerova H, Dubrovsky L, Flanagan CR, Mullins ME, Lipton SA, Gendelman HE. Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HSV-1)-infected monocytes: Implications for HIV-associated neurological disease. J Exp Med 181:735-745, 1995.
52. Pietraforte D, Tritarelli E, Testa U, Minetti M. gp120 HIV envelope glycoprotein increases the production of nitric oxide in human monocyte-derived macrophages. J Leukoc Biol 55:175-182, 1994.
53. Dawson VL, Dawson TM, Uhl GR, Snyder SH. Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc Natl Acad Sci USA 90:3256-3259, 1993.
54. Kreil TR, Eibl MM. Viral infection of macrophages profoundly alters requirements for induction of nitric oxide synthesis. Virology 212:174-178, 1995.
55. Wright PF. Respiratory diseases. In: Nathanson N, Ahmed R, Gonzalez-Scarano F, Griffin DE, Holmes KV, Murphy FA, Robinson HL, Eds. Viral Pathogenesis. Philadelphia: Lippincott-Raven Publishers, pp703-711, 1997.
56. Bogdan C, Vodovotz Y, Paik J, Xie Q, Nathan C. Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages. J Leukoc Biol 55:227-233, 1994.
57. Cunha FQ, Moncada S, Liew FY. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages. Biochem Biophys Res Commun 182:1155-1159, 1992.
58. Vodovotz Y, Bogdan C, Paik J, Xie Q, Nathan C. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor β. J Exp Med 178:605-613, 1993.
59. Gotoh T, Sonoki T, Nagasaki A, Terada K, Takiguchi M, Mori M. Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line. FEBS Lett 395:119-122, 1996.
60. Sonoki T, Nagasaki A, Gotoh T, Takiguchi M, Takeya M, Matsuzaki H, Mori M. Coinduction of nitric oxide synthase and arginase I in cultured rat peritoneal macrophages and rat tissues in vivo by lipopolysaccharide. J Biol Chem 272:3689-3693, 1997.
61. 2) in murine bone marrow-derived macrophages. Biochem Biophys Res Commun 206:667-673, 1995.
62. Akaike T, Maeda H. Quantitation of nitric oxide using 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO). Methods Enzymol 268:211-221, 1996.
63. Kosaka H, Sawai Y, Sakaguchi H, Kumura E, Harada N, Watanabe M, Shiga T. ESR spectral transition by arteriovenous cycle in nitric oxide hemoglobin of cytokine-treated rats. Am J Physiol 266:C1400-C1405, 1994.
64. Doi K, Akaike T, Horie H, Noguchi Y, Fujii S, Beppu T, Ogawa M, Maeda H. Excessive production of nitric oxide in rat solid tumor and its implications in rapid tumor growth. Cancer (Suppl) 77:1598-1604, 1996.
65. Setoguchi K, Takeya M, Akaike T, Suga M, Hattori R, Maeda H, Ando M, Takahashi K. Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats. Am J Pathol 149:2005-2022, 1996.
66. Yoshimura T, Yokoyama H, Fuji S, Takayama F, Oikawa K, Kamada H. In vivo EPR detection and imaging of endogenous nitric oxide in lipopolysaccharide-treated mice. Nat Biotechnol 14:992-994, 1996.
67. Doi T, Ando M, Akaike T, Suga M, Sato K, Maeda H. Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis. Infect Immun 61:1980-1989, 1993.
68. James SL. Role of nitric oxide in parasitic infections. Microbiol Rev 59:533-547, 1995.
69. Karupiah G, Xie Q, Buller RML, Nathan C, Duarte C, MacMicking JD. Inhibition of viral replication by interferon-γ-induced nitric oxide synthase. Science 261:1445-1448, 1993.
70. Croen KD. Evidence for an antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication. J Clin Invest 91:2446-2452, 1993.
71. Rolph MS, Ramshaw IA, Rockett KA, Ruby J, Cowden WB. Nitric oxide production is increased during murine vaccinia virus infection, but may not be essential for virus clearance. Virology 217:470-477, 1996.
72. Lepoivre M, Fieschi F, Coves J, Thelander L, Fontecave M. Inactivation of ribonucleotide reductase by nitric oxide. Biochem Biophys Res Commun 179:442-148, 1991.
73. Cleeter MWJ, Cooper JM, Darley-Usmar VM, Moncada S, Schapiva AHV. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide: Implications for neurodegenerative diseases. FEBS Lett 345:50-54, 1994.
74. Mannick JB, Asano K, Izumi K, Kieff E, Stamler JS. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell 79:1137-1146, 1994.
75. Nakamura H, Furuke K, Matsuda M, Inamoto T, Yodoi J. Adult T-cell leukemia-derived factor as an endogenous radical scavenger. Adv Exp Med Biol 371B:909-911, 1995.
76. Leopardi R, Roizman B. The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by hyperthermia. Proc Natl Acad Sci USA 93:9583-9587, 1996.
77. Kato A, Kiyotani K, Sakai Y, Yoshida T, Nagai Y. The paramyxovirus, Sendai virus, V protein encodes a luxury function required for viral pathogenesis. EMBO J 16:578-587, 1997.
78. Beckman JS, Ye YZ, Anderson PG, Chen J, Accavitti MA, Tarpey MM, White CR. Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol Chem 375:81-88, 1994.
79. Haddad IY, Pataki G, Hu P, Galliani C, Beckman JS, Matalon S. Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury. J Clin Invest 94:2407-2413, 1994.
80. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys 288:481-487, 1991.
81. Haddad IY, Ischiropoulos B, Holm BA, Beckman JS, Baker JR, Matalon S. Mechanism of peroxynitrite-induced injury to pulmonary surfactant. Am J Physiol 265:L555-L564, 1993.
82. Castro L, Rodriguez M, Radi R. Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide. J Biol Chem 269:29409-29415, 1994.
83. Hausladen A, Fridovich I. Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not. J Biol Chem 269:29405-29408, 1994.
84. Radi R, Rodriguez M, Castro L, Telleri R. Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophys 308:89-95, 1994.
85. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite oxidation of sulfhydryls. J Biol Chem 266:4244-4250, 1991.
86. Zhu L, Gunn C, Beckman JS. Bactericidal activity of peroxynitrite. Arch Biochem Biophys 298:452-457, 1992.
87. Bonfoco E, Kraine D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/ superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92:7162-7166, 1995.
88. Troy CM, Derossi D, Prochiantz A, Greene LA, Shelanski ML. Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. J Neurosci 16:253-261, 1996.
89. Estevez AG, Radi R, Barbeito L, Shin JT, Thompson JA, Beckman JS. Peroxynitrite-induced cytotoxicity in PC12 cells: Evidence for an apoptotic mechanism differentially modulated by neurotrophic factors. J Neurochem 65:1543-1550, 1995.
90. Ischiropoulos H, Al-Mehdi A, Fisher AB. Reactive species in ischemic rat lung injury: Contribution of peroxynitrite. Am J Physiol 269:L158-L164, 1995.
91. Berlett BS, Friguet B, Yim MB, Chock PB, Stadtman ER. Peroxynitrite-mediated nitration of tyrosine residues in Escherichia coli glutamine synthetase mimics adenylation: Relevance to signal transduction. Proc Natl Acad Sci USA 94:1776-1780, 1996.
92. 2 peptide. Proc Natl Acad Sci USA 93:3377-3382, 1996.
93. Uppu RM, Squadrito GL, Pryor W. Acceleration of peroxynitrite oxidations by carbon dioxide. Arch Biochem Biophys 327:335-343, 1996.
94. Garrett RH, Grisham CM. Water, pH, and ionic equilibria. In: Biochemistry. Fort Worth, Texas: Saunders College Publishing, pp32-54, 1995.
95. Okamoto T, Akaike T, Suga M, Tanase S, Horie H, Miyajima S, Ando M, Ichinose Y, Maeda H. Activation of human matrix metalloproteinases by various bacterial proteinases. J Biol Chem 272:6059-6066, 1997.
96. Okamoto T, Akaike T, Nagano T, Miyajima S, Suga M, Ando M, Ichimori K, Maeda H. Activation of human neutrophil procollagenase by nitrogen dioxide and peroxynitrite: A novel mechanism of procollagenase activation involving nitric oxide. Arch Biochem Biophys, 342:261-274, 1997.
97. 1-proteinase inhibitor by peroxynitrite. Chem Res Toxicol 5:425-431, 1992.
98. Frears ER, Zhang Z, Blake DR, O'Connell JP, Winyard PG. Inactivation of tissue inhibitor of metalloproteinase-1 by peroxynitrite. FEBS Lett 381:21-24, 1996.
99. 1-antiproteinase inactivation by oxidized and reduced lipoic acid. FEBS Lett 379:74-76, 1996.
100. Landino LM, Crews BC, Timmons MD, Morrow JD, Marnett LJ. Peroxinitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis. Proc Natl Acad Sci USA 93:15069-15074, 1996.
101. Clancy RM, Abramson SB. Nitric oxide: A novel mediator of inflammation. Proc Soc Exp Biol Med 210:93-101, 1995.
102. Kubes P. Nitric oxide affects microvascular permeability in the intact and inflamed vasculature. Microcirculation 2:235-244, 1995.
103. Umezawa K, Akaike T, Fujii S, Suga M, Setoguchi K, Ozawa A, Maeda H. Induction of nitric oxide synthesis and xanthine oxidase and their role in the antimicrobial mechanism against Salmonella typhimurium in mice. Infect Immun 65:2932-2940, 1997.
104. Umezawa K, Ohnishi N, Tanaka K, Kamiya S, Koga Y, Nakazawa H, Ozawa A. Granulation in livers of mice infected with Salmonella lyphimurium is caused by superoxide released from host phagocytes. Infect Immun 63:4402-4408, 1995.
105. Kornellisse RF, Hoekman K, Visser JJ, Hop WCJ, Huijmans JGM, van der Straaten PJC, van der Heijden AJ, Sukhai RN, Neijens HJ, de Groot R. The role of nitric oxide in bacterial meningitis in children. J Infect Dis 174:120-126, 1996.
106. Vuillaume M. Reduced oxygen species, mutation, induction, and cancer initiation. Mutat Res 186:43-72, 1987.
107. Liu RH, Hotchkiss JH. Potential genotoxicity of chronically elevated nitric oxide: A review. Mutat Res 339:73-89, 1995.
108. Ohshima H, Bartsch H. Chronic infections and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis. Mutat Res 305:253-264, 1994.