Identification of human glandular kallikrein hK2 from LNCaP cells

Journal of Andrology

Volumn 17, Issue 4, 1996, Pages 353-359

  Grauer, Lana S ^a   Charlesworth, M Cristine ^b   Saedi, Mohammad S ^b   Finlay, Judith A ^b   Liu, Ru Shya ^b   Kuus Reichel, Kristine ^b   Young, Charles Y F ^b   Tindall, Donald J ^b  

^a Hybritech Incorporated   (United States)

^b NONE

Author keywords

monoclonal antibody; Prostate carcinoma; seminal fluid

Indexed keywords

KALLIKREIN; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ARTICLE; CANCER CELL CULTURE; KALLIKREIN KININ SYSTEM; MOLECULAR CLONING; PRIORITY JOURNAL; PROSTATE CANCER; SEMINAL PLASMA; SEQUENCE HOMOLOGY;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; CYTOSOL; HUMANS; KALLIKREINS; MALE; PROSTATIC NEOPLASMS; RNA, MESSENGER; SEMEN; TISSUE KALLIKREINS; TUMOR CELLS, CULTURED;

EID: 0029817171     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Berg T, Bradshaw RA, Carretero OA, Chao J, Chao L, Clements JA, Fahnestock M, Fritz H, Gauthier RJ, MacDonald RJ, Margolius HS, Morris BJ, Richards RI, Scicli AG. A common nomenclature for members of the tissue (glandular) kallikrein gene families. Agents Actions 1992;38(suppl 1):19-25.
2. Chapdelaine P, Paradis G, Tremblay RR, Dube JY. High level of expression in the prostate of a human glandular kallikrein mRNA related to prostate-specific antigen. FEBS Lett 1988;236:205-208.
3. Clements J. The glandular kallikrein family of enzymes: tissue-specific expression and hormonal regulation. Endocrine Rev 1989;10:393-419.
4. Deperthes D, Chapdelaine P, Tremblay R, Brunet C, Berton J, Hebert J, Lazure C, Dube J. Isolation of prostatic kallikrein hK2, also known as hGK-1, in human seminal plasma. Biochim Biophys Acta 1995;1245:311-316.
5. Espana F, Gilabert J, Estelles A, Romeu A, Aznar J, Cabo A. Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen. Thromb Res 1991;64:309-320.
6. Henttu P, Lukkarinen O, Vihko P. Expression of the gene coding for human prostate specific antigen and related hGK-1 in benign and malignant tumors of the human prostate. Int J Cancer 1990;45:654-660.
7. Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256:495-497.
8. Laurell M, Christensson A, Abrahamsson PA, Stenflo J, Lilja H. Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system. J Clin Invest 1992;89:1094-1101.
9. Lilja H. A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein. J Clin Invest 1985;76:1899-1903.
10. Lilja H, Oldbring J, Rannevik G, Laurell CB. Seminal vesicle-secreted proteins and their reactions during gelation and liquefaction of human semen. J Clin Invest 1987;80:281-285.
11. Lundwall A, Lilja H. Molecular cloning of human prostate specific antigen cDNA. FEBS Lett 1987;214:317-322.
12. Morris BJ. hGK-1: A kallikrein gene expressed in human prostate. Clin Exp Pharm Phys 1989;16:345-351.
13. Murray SR, Chao J, Lin FK, Chao L. Kallikrein multigene families and the regulation of their expression. J Cardiovasc Pharmacol 1990;15: S7-S16.
14. Paradis G, Tremblay RR, Dube JY. Looking for human glandular kallikrein-1 in the prostate. Prostate 1989;15:343-353.
15. Saedi M, Cass MJ, Goel AS, Grauer L, Okaneya T, Young C, Tindall D. Overexpression of a human prostate-specific glandular kallikrein, hK2 and generation of antibody. Mol Cell Endocrinol 1995;109:237-241.
16. Schedlich LJ, Bennetts B, Morris B. Primary structure of a human glandular kallikrein gene. DNA 1987;6:429-437.
17. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4354.
18. Wang MC, Valenzuela LA, Murphy GP, Chu TM. Purification of a human prostate specific antigen. Invest Urol 1979;17:159-163.
19. Watt KWK, Lee PJL, Timkulu TM, Chan WP, Loor R. Human prostatespecific antigen: structural and functional similarity with serine proteases. Proc Natl Acad Sci USA 1986;83:3166-3170.
20. Young CY-F, Andrews PE, Montgomery BT, Tindall DJ. Tissue-specific and hormonal regulation of human prostate-specific glandular kallikrein. Biochemistry 1992;31:818-824.