Maleimidocysteineamido-DOTA derivatives: New reagents for radiometal chelate conjugation to antibody sulfhydryl groups undergo pH-dependent cleavage reactions

Bioconjugate Chemistry

Volumn 9, Issue 1, 1998, Pages 72-86

  Lewis, Michael R ^a   Shively, John E ^b  

^a City Hope Grad Prog in Biol Sci   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHELATION; COVALENT BONDS; MASS SPECTROMETRY; SOLUTIONS; SULFUR COMPOUNDS; TUMORS;

BI-FUNCTIONAL; CLEAVAGE REACTION; MACROCYCLICS; MALEIMIDES; NORMAL TISSUE; PH-DEPENDENT; RADIOIMMUNOCONJUGATES; RADIOMETAL CHELATES; SULFHYDRYL GROUPS; SYNTHESISED;

MONOCLONAL ANTIBODIES;

EID: 0031982801     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc970136v     Document Type: Article

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