Biodistribution of 111In- and 90Y-labeled DOTA and maleimidocysteineamido-DOTA conjugated to chimeric anticarcinoembryonic antigen antibody in xenograft-bearing nude mice: Comparison of stable and chemically labile linker systems

Bioconjugate Chemistry

Volumn 9, Issue 1, 1998, Pages 87-93

  Williams, Lawrence E ^a   Lewis, Michael R ^b   Bebb, Gregory G ^a   Clarke, Kenneth G ^a   Odom Maryon, Tamara L ^a   Shively, John E ^a   Raubitschek, Andrew A ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b City Hope Grad Prog in Biol Sci   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BLOOD; BONE; CHELATION; DOSIMETRY; MAMMALS; TUMORS;

BIODISTRIBUTIONS; BONE MARROW; CHELATING AGENT; COLORECTAL CARCINOMA; LINKER SYSTEM; MACROCYCLICS; NUDE MICE; RADIOMETAL CHELATES; TETRAACETIC ACID; TIME POINTS;

MONOCLONAL ANTIBODIES;

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; 1,4,7,10-TETRAAZACYCLODODECANE- 1,4,7,10-TETRAACETIC ACID; CARCINOEMBRYONIC ANTIGEN; CHELATING AGENT; HETEROCYCLIC COMPOUND; INDIUM; MALEIMIDE DERIVATIVE; MONOCLONAL ANTIBODY; SINGLE HETEROCYCLIC RINGS; YTTRIUM;

ANIMAL; ARTICLE; BONE; BONE MARROW; CANCER TRANSPLANTATION; CHEMISTRY; COLORECTAL TUMOR; DRUG STABILITY; HUMAN; IMMUNOLOGY; ISOTOPE LABELING; METABOLISM; MOUSE; NUDE MOUSE; TISSUE DISTRIBUTION; XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; BONE AND BONES; BONE MARROW; CARCINOEMBRYONIC ANTIGEN; CHELATING AGENTS; COLORECTAL NEOPLASMS; DRUG STABILITY; HETEROCYCLIC COMPOUNDS; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; INDIUM RADIOISOTOPES; ISOTOPE LABELING; MALEIMIDES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS; YTTRIUM RADIOISOTOPES;

EID: 0031594362     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc970137n     Document Type: Article

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