메뉴 건너뛰기




Volumn 4, Issue 4, 1997, Pages 317-322

An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast carcinoma cells overexpressing erbB-2

Author keywords

Breast cancer; ErbB 2; Gene therapy; Single chain antibody

Indexed keywords

ANTIBODY; ONCOPROTEIN;

EID: 0030935529     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300372     Document Type: Article
Times cited : (48)

References (26)
  • 1
    • 0022399581 scopus 로고
    • Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
    • Coussens L et al. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 1985; 230: 1132-1139.
    • (1985) Science , vol.230 , pp. 1132-1139
    • Coussens, L.1
  • 2
    • 0022588467 scopus 로고
    • Similarity of protein encoded by the human c-erbB-2 gene to the epidermal growth factor receptor
    • Yamamoto T et al. Similarity of protein encoded by the human c-erbB-2 gene to the epidermal growth factor receptor. Nature 1986; 319: 230-234.
    • (1986) Nature , vol.319 , pp. 230-234
    • Yamamoto, T.1
  • 3
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon DJ et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989; 244: 707-712.
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1
  • 4
    • 0025190758 scopus 로고
    • Expression of the neu gene-encoded protein (p185neu) in human non-small cell carcinomas of the lung
    • Weiner DB et al. Expression of the neu gene-encoded protein (p185neu) in human non-small cell carcinomas of the lung. Cancer Res 1990; 50: 421-425.
    • (1990) Cancer Res , vol.50 , pp. 421-425
    • Weiner, D.B.1
  • 5
    • 0022647499 scopus 로고
    • Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line
    • Fukushige S et al. Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line. Mol Cell Biol 1986; 6: 955-958.
    • (1986) Mol Cell Biol , vol.6 , pp. 955-958
    • Fukushige, S.1
  • 6
    • 0010066582 scopus 로고
    • A v-erbB-related proto-oncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma
    • Semba K, Kamata N, Toyoshima K, Yamamoto T. A v-erbB-related proto-oncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma. Proc Natl Acad Sci USA 1985; 82: 6497-6501.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 6497-6501
    • Semba, K.1    Kamata, N.2    Toyoshima, K.3    Yamamoto, T.4
  • 7
    • 0023301170 scopus 로고
    • Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms
    • Kraus MH, Popescu NC, Amsbaugh SC, King CR. Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J 1987; 6: 605-610.
    • (1987) EMBO J , vol.6 , pp. 605-610
    • Kraus, M.H.1    Popescu, N.C.2    Amsbaugh, S.C.3    King, C.R.4
  • 8
    • 0024516756 scopus 로고
    • Overexpression of the c-erbB-2 protein in human breast rumor lines
    • Hynes NE, Gerber HA, Saurer S, Groner B. Overexpression of the c-erbB-2 protein in human breast rumor lines. J Cell Biochem 1989; 39: 167-173.
    • (1989) J Cell Biochem , vol.39 , pp. 167-173
    • Hynes, N.E.1    Gerber, H.A.2    Saurer, S.3    Groner, B.4
  • 9
    • 0025154964 scopus 로고
    • Increased erbB-2 gene copies and expression in multiple stages of breast cancer
    • Iglehart JD et al. Increased erbB-2 gene copies and expression in multiple stages of breast cancer. Cancer Res 1990; 50: 6701-6707.
    • (1990) Cancer Res , vol.50 , pp. 6701-6707
    • Iglehart, J.D.1
  • 10
    • 0027243329 scopus 로고
    • A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-erbB-2 in mammary tumour lines
    • Hollywood DP, Hurst HC. A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-erbB-2 in mammary tumour lines. EMBO J 1993; 12: 2369-2375.
    • (1993) EMBO J , vol.12 , pp. 2369-2375
    • Hollywood, D.P.1    Hurst, H.C.2
  • 11
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1
  • 12
    • 0025360473 scopus 로고
    • Her-2/neu amplification predicts poor survival in node-positive breast cancer
    • Borg A et al. Her-2/neu amplification predicts poor survival in node-positive breast cancer. Cancer Res 1990; 50: 4332-4337.
    • (1990) Cancer Res , vol.50 , pp. 4332-4337
    • Borg, A.1
  • 13
    • 0026650016 scopus 로고
    • Prognostic significance of HER-2 oncoprotein expression in breast cancer: A 30 year follow-up
    • Toikkanen S, Helin H, Isola J, Joensuu H. Prognostic significance of HER-2 oncoprotein expression in breast cancer: a 30 year follow-up. J Clin Oncol 1992; 10: 1044-1048.
    • (1992) J Clin Oncol , vol.10 , pp. 1044-1048
    • Toikkanen, S.1    Helin, H.2    Isola, J.3    Joensuu, H.4
  • 14
    • 0028500163 scopus 로고
    • Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines
    • Deshane J et al. Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines. Gene Therapy 1994; 1: 332-337.
    • (1994) Gene Therapy , vol.1 , pp. 332-337
    • Deshane, J.1
  • 15
    • 0028148050 scopus 로고
    • Intracellular expression of single chain antibodies reverts erbB-2 transformation
    • Beerli RR, Wels W, Hynes NE. Intracellular expression of single chain antibodies reverts erbB-2 transformation. J Biol Chem 1994; 269: 23931-23936.
    • (1994) J Biol Chem , vol.269 , pp. 23931-23936
    • Beerli, R.R.1    Wels, W.2    Hynes, N.E.3
  • 16
    • 0030101361 scopus 로고    scopus 로고
    • Intracellular antibody directed against erbB-2 mediates tumor cell eradication by inducing apoptosis
    • Deshane J et al. Intracellular antibody directed against erbB-2 mediates tumor cell eradication by inducing apoptosis. Cancer Gene Ther 1996; 3: 89-98.
    • (1996) Cancer Gene Ther , vol.3 , pp. 89-98
    • Deshane, J.1
  • 17
    • 0028839655 scopus 로고
    • Targeted tumor killing via an intracellular antibody against erbB-2
    • Deshane J et al. Targeted tumor killing via an intracellular antibody against erbB-2. J Clin Invest 1995; 96: 2980-2989.
    • (1995) J Clin Invest , vol.96 , pp. 2980-2989
    • Deshane, J.1
  • 18
    • 0028823836 scopus 로고
    • Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbB-2 single-chain antibody
    • Deshane J et al. Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbB-2 single-chain antibody. Gynecol Oncol 1995; 59: 8-14.
    • (1995) Gynecol Oncol , vol.59 , pp. 8-14
    • Deshane, J.1
  • 19
    • 0026718827 scopus 로고
    • ErbB-2 amplification in breast cancer analyzed by flourescence in situ hybridization
    • Kallioniemi OP et al. ErbB-2 amplification in breast cancer analyzed by flourescence in situ hybridization. Proc Natl Acad Sci USA 1992; 89: 5321-5325.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5321-5325
    • Kallioniemi, O.P.1
  • 20
    • 0027208701 scopus 로고
    • C-erbB-2 amplification and overexpression in breast cancer: Evaluation and comparison of Southern blot, slot blot, ELISA and immunohistochemistry
    • Dawkins HJ et al. C-erbB-2 amplification and overexpression in breast cancer: evaluation and comparison of Southern blot, slot blot, ELISA and immunohistochemistry. Pathology 1993; 25: 124-132.
    • (1993) Pathology , vol.25 , pp. 124-132
    • Dawkins, H.J.1
  • 21
    • 0028848397 scopus 로고
    • Her-2 overexpression, and intratumor heterogeneity in human breast cancer
    • Her-2 overexpression, and intratumor heterogeneity in human breast cancer. Cancer Res 1995; 55: 5400-5407.
    • (1995) Cancer Res , vol.55 , pp. 5400-5407
    • Szöllösi, J.1
  • 22
    • 0001062172 scopus 로고
    • Clinical Protocols
    • Clinical Protocols. Cancer Gene Ther 1995; 2: 137-145.
    • (1995) Cancer Gene Ther , vol.2 , pp. 137-145
  • 23
    • 0028330866 scopus 로고
    • In vitro generation of human cytolytic T cells specific for peptides derived from the HER-2/neu protooncogene protein
    • Disis ML et al In vitro generation of human cytolytic T cells specific for peptides derived from the HER-2/neu protooncogene protein. Cancer Res 1994; 54: 1071-1076.
    • (1994) Cancer Res , vol.54 , pp. 1071-1076
    • Disis, M.L.1
  • 24
    • 0028328257 scopus 로고
    • Cytotoxic T lymphocytes with a grafted recognition specificity for erbB2-expressing tumor cells
    • Moritz D, Winfried W, Mattern J, Groner B. Cytotoxic T lymphocytes with a grafted recognition specificity for erbB2-expressing tumor cells. Proc Natl Acad Sci USA 1994; 91: 4318-4322.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4318-4322
    • Moritz, D.1    Winfried, W.2    Mattern, J.3    Groner, B.4
  • 25
    • 0025145020 scopus 로고
    • The extracellular domain of HER2/neu is a potential immunogen for active specific immunotherapy of breast cancer
    • Fendly BM et al The extracellular domain of HER2/neu is a potential immunogen for active specific immunotherapy of breast cancer. J Biol Resp Mod 1990; 9: 449-455.
    • (1990) J Biol Resp Mod , vol.9 , pp. 449-455
    • Fendly, B.M.1
  • 26
    • 0030236157 scopus 로고    scopus 로고
    • ErbB-2 knockout employing an intracellular singlechain antibody (sFv) accomplishes specific cytotoxicity in erbB-2 expressing lung cancer cells
    • Grim J et al. ErbB-2 knockout employing an intracellular singlechain antibody (sFv) accomplishes specific cytotoxicity in erbB-2 expressing lung cancer cells. Am J Resp Cell Mol Biol 1996, 15: 348-354.
    • (1996) Am J Resp Cell Mol Biol , vol.15 , pp. 348-354
    • Grim, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.