Early evaluation of abdominal/hepatic irradiation and 5-fluorouracil/leucovorin infusion after pancreaticoduodenectomy

International Journal of Radiation Oncology Biology Physics

Volumn 35, Issue 1, 1996, Pages 143-150

  Carducci, Michael A ^a   Abrams, Ross A ^a   Yeo, Charles J ^a   Hruban, Ralph H ^a   Zahurak, Marianna L ^a   Cameron, John L ^a   Grochow, Louise B ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Adjuvant therapy; Pancreatic neoplasm

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ADJUVANT THERAPY; ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER GRADING; CANCER SURVIVAL; CLINICAL ARTICLE; EARLY DIAGNOSIS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER INJURY; PANCREAS TUMOR; PANCREATICODUODENECTOMY; PATIENT COMPLIANCE; PRIORITY JOURNAL; TREATMENT PLANNING;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; FEMALE; FLUOROURACIL; HUMANS; LEUCOVORIN; LIVER; MALE; MIDDLE AGED; PANCREAS; PANCREATIC NEOPLASMS; PANCREATICODUODENECTOMY; SURVIVAL ANALYSIS;

EID: 0029871288     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(96)85023-1     Document Type: Article

References (33)

1. Anderson, N.; Lokich, J.; Bern, M.; Wallach, S.; Moore, C.; Williams, D. A phase I trial of combined fluoropyrimidines with leucovorin in a 14 day infusion: Demonstration of biochemical modulation. Cancer 63:233-237, 1989.
2. Bleyer, W. A. New vistas for leucovorin in cancer chemotherapy. Cancer 63:995-1007, 1989.
3. Bosset, J. F.; Pavy, J. J.; Gillet, M.; Manhon, G,; Pelissier, E.; Schraub, S. Conventional external irradiation alone as adjuvant treatment in resectable pancreatic cancer: Results of a prospective study. Radiother. Oncol. 24:191-194, 1992.
4. Byfield, J. E.; Calabro-Jones, P.; Klisak, I.; Kulhanian, F. Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or ftorafur and xrays. Int. J. Radiat. Oncol. Biol. Phys. 8:1923-1933, 1982.
5. Cameron, J. L.; Pitt, H. A.; Yeo, C. J.; Lillemoe, K. D.; Kaufman, H. S.; Coleman, J. One hundred and forty-five consecutive pancreaticoduodenectomies without mortality. Ann. Surg. 217:430-438, 1993.
6. Cox, D. R. Regression models and life tables (with discussion) J. R. Stat. Soc. B 34:187-220, 1972.
7. Crist, D. W.; Cameron, J. L. The current status of the Whipple operation for periampullary carcinoma. Adv. Surg. 25: 21-49, 1992.
8. Crist, D. W.; Cameron, J. L. Current status of pancreaticoduodenectomy for periampullary carcinoma. Hepatogastroenterology 36:478-485, 1989.
9. Crist, D. W.; Sitzman, J. V.; Cameron, J. L. Improved hospital morbidity, mortality, and survival after the Whipple procedure. Ann. Surg. 206:358-365; 1987.
10. Dobelbower, R. R.; Borgelt, B. B.; Strubler, K. A.; Kutcher, G. J.; Suntharalingam, N. Precision radiotherapy of cancer of the pancreas: Techniques and results. Int. J. Radiat. Oncol. Biol. Phys. 6:1127-1133; 1980.
11. Dobelbower, R. R.; Borgelt, B. B.; Suntharalingam, N.; Strubler, K. A. Pancreatic carcinoma treated with high-dose small volume irradiation. Cancer 41:1087-1092; 1978.
12. Gastrointestinal Tumor Study Group: Adjuvant therapy with hepatic irradiation plus fluorouracil in colon carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 21:1151-1156, 1991.
13. Gastrointestinal Tumor Study Group: Comparative therapeutic trial of radiation with or without chemotherapy in pancreatic carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 5:1643-1647; 1979.
14. Gastrointestinal Tumor Study Group. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 59:2006-2010; 1987.
15. Hansen, R. M. 5-Fluorouracil by protracted venous infusion: A review of recent clinical studies. Cancer Invest. 9:637-642; 1991.
16. Hansen, R.; Quebbeman, E.; Ausman, R.; Frick, J.; Ritch, P.; Schulte, W.; Haas, C.; Beatty, P.; Anderson, T. Continuous systemic 5-fluorouracil (5-FU) infusion in advanced colorectal cancer. Results in 91 patients. J. Surg. Oncol. 40:177-181; 1989.
17. Hansen, R.; Quebbeman, E.; Ritch, P.; Chitambar, C.; Anderson, T. Continuous 5-fluorouracil (5-FU) infusion in carcinoma of the pancreas. Am. J. Med. Sci. 295:91-93; 1988.
18. Herbsman, H.; Hassan, A.; Gardner, B.; Harshaw, D.; Bohorquez, J.; Alfonso, A.; Newman, J. Treatment of hepatic metastases with a combination of hepatic artery infusion chemotherapy and external radiotherapy. Surg. Gynecol. Obstet. 147:13-17; 1978.
19. Kalser, M. H.; Ellenberg, S. S. Pancreatic cancer: Adjuvant combined radiation and chemotherapy following curative resection. Arch. Surg. 120:899-903, 1985.
20. Kaplan, E. L.; Meier, P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53:457-481; 1958.
21. Karnofsky, D. A.; Ableman, W. H.; Craver, L. F. The use of nitrogen mustards in the palliative treatment of carcinoma. Cancer 1:634-656; 1948.
22. Kinsella, T. J. Adjuvant radiotherapy in pancreatic carcinoma: A reappraisal. Cancer Invest. 6:745-746; 1988.
23. Klaassen, D. J.; Maclntyre, J. M.; Catton, G. E.; Engstrom, P. F.; Moertel, C. G. Treatment of locally unresectable cancer of the stomach and pancreas. A randomized comparison of 5-fluorouracil alone or with radiation plus concurrent and maintenance 5-fluorouracil An ECOG study. J. Clin. Oncol. 3:373-378; 1985.
24. Komaki, R.; Wilson, J. F.; Cox, J. D.; Kline, R. W. Carcinoma of the pancreas: Results of irradiation for unresectable lesions. Int. J. Radiat. Oncol. Biol. Phys. 6:209-212; 1980.
25. Komaki, R.; Hansen, R.; Cox, J. D.; Wilson, J. F. Phase I-II study of prophylactic hepatic irradiation with local irradiation and systemic chemotherapy for adenocarcinoma of the pancreas. Int. J. Radiat. Oncol. Biol. Phys. 15:1447-1452; 1988.
26. Lawrence, T. S.; Heimburger, D. K.; Shewach, D. S. The effects of leucovorin and dipyridamole on fluoropyrimidine-induced radiosensitization. Int. J. Radiat. Oncol. Biol. Phys. 20:377-381; 1991.
27. Mantel, N.; Haentzel, W. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer. Inst. 22:719-749; 1959.
28. Peters, G. J.; van Groeningen, C. J.; van der Wilt, C. L.; Meijer, S.; Sid, K.; Laurensse, E.; Pinedo, H. M. Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin. Semin. Oncol. 19:26-35; 1992.
29. Quebbeman, E.; Ausman, R.; Hansen, R.; Becker, T.; Caballeros, G.; Ritch, P.; Jenkins, D.; Blake, D.; Tangen, L.; Schulte, W. Long term ambulatory treatment of colorectal adenocarcinoma by continuous infusion of 5-fluorouracil. J. Surg. Oncol. 30:60-65; 1985.
30. Sack, G. H.; Levin, J.; Bell, W. R. Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: Clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore) 56:1; 1977.
31. Schober, C.; Bokemeyer, C.; Stahl, M.; Wilke, H. J.; Schmoll, H. J.; Poliwoda, H. The role of schedule dependency of 5-fluorouracil/leucovorin combinations in advanced colorectal cancer. Semin. Oncol. 19:131-135; 1992
32. van der Wilt, C. L.; Pinedo, H. M.; Smid, K.; Cloos, J.; Noordhuis, P.; Petus, G. J. Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase. Semin. Oncol. 19:16-25; 1992.
33. Whittington, R.; Bryer, M. P.; Haller, D. G.; Solin, L. J.; Rosato, E. F. Adjuvant therapy of resected adenocarcinoma of the pancreas. Int. J. Radiat. Oncol. Biol. Phys. 21:1137-1147; 1991.