Modulation of hepatocyte growth factor-induced scattering of HT29 colon carcinoma cells. Involvement of the MAPK pathway

Journal of Cell Science

Volumn 111, Issue 8, 1998, Pages 1039-1049

  Herrera, Roman ^a  

^a PFIZER INC   (United States)

Author keywords

Cellular adhesion; HT29 cell; MAPK; Scatter factor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CATENIN; LAMININ; MITOGEN ACTIVATED PROTEIN KINASE; PAXILLIN; PHORBOL 13 ACETATE 12 MYRISTATE; PLASMA PROTEIN; SCATTER FACTOR; UVOMORULIN;

ARTICLE; CELL MOTILITY; CELL SPREADING; CELL STRAIN HT29; DESMOSOME; EPITHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ACTINS; ARACHIDONIC ACID; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARCINOGENS; CELL ADHESION; CELL MOVEMENT; COLLAGEN; DESMOSOMES; ENZYME INHIBITORS; EXTRACELLULAR MATRIX PROTEINS; FLAVONOIDS; HEPATOCYTE GROWTH FACTOR; HT29 CELLS; HUMANS; LAMININ; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE;

EID: 0031971198     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (78)

1. Agrez, M. V. and Bates, R. C. (1994). Colorectal cancer and the integrin family of cell adhesion receptors: current status and future directions. Eur. J. Cancer 30A, 2166-2170.
2. Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T. and Saltiel, A. R. (1995). PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo J. Biol. Chem. 270, 27489-27494.
3. 1 integrins signal lipid second messengers required during cell adhesion. Mol. Biol. Cell 6, 1305-1313.
4. Behrens, J., Vakaet, L., Friis, R., Winterhager, E., Van Roy, F., Mareel, M. M. and Birchmeier, W. (1997). Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J. Cell Biol. 120, 757-766
5. Blenis, J. (1993). Signal transaction via the MAP kinases Proceed at your own RSK. Proc. Nat. Acad. Sci. USA 90, 5889-5892.
6. Bockholt, S. M. and Burridge, K. (1993) Cell spreading on extracellular matrix proteins induces tyrosine phosphoryylation of tensin. J. Biol. Chem. 268, 14565-14567.
7. Bouziges, F., Simo. P., Simon-Assmann, P., Haffen, K. and Kedinger, M. (1991). Altered deposition of basement-membrane molecules in co-cultures of colonie cancer cells and fibroblasts. Int. J. Cancer 48, 101-108.
8. Braga, V. M. M., Machesky, L. M., Hall, A. and Hotchin, N. A. (1997) The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137, 1421-1431.
9. Brinkmann, V., Foroutan, H., Sachs, M., Weidner, K. M. and Birchmeier, W. (1995). Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells. J. Cell Biol. 131, 1573-1586.
10. FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J. Cell Biol. 119, 893-903.
11. Chen, Q., Kinch, M. S., Lin, T. H., Burridge, K. and Juliano, R. L. (1994) Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J. Biol. Chem. 269, 26602-26605.
12. Chun, J.-S., Ha, M.-J. and Jacobson, B. S. (1996). Differential translocation of protein kinase C ε during HeLa cell adhesion to a gelatin substratum. J. Biol. Chem. 271, 13008-13012.
13. Citi, S. (1993). The molecular organization of tight junctions. J. Cell Biol. 121, 485-489.
14. Clark, P. (1994). Modulation of scatter factor/hepatocyte growth factor activity by cell-substratum adhesion. J. Cell Sci. 107, 1265-1275.
15. Cobb, M. H. and Goldsmith, E. J. (1995) How MAP kinases are regulated J. Biol. Chem. 270, 14843-14846.
16. as binds directly to E-cadherin but not the adenomatous polyposis coli protein or α-catenin. Mol. Cell Biol. 15, 4819-4824.
17. Drubin, D. G. and Nelson, W. J. (1996). Origins of cell polarity. Cell 84, 335-344.
18. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J. and Saltiel, A. R. (1995). A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Nat. Acad. Sci. USA 92, 7686-7689.
19. Finnemann, S., Kuhl, M., Otto, G. and Wedlich, D. (1995) Cadherin transfection of Xenopus XTC cells downregulates expression of substrate adhesion molecules. Mol. Cell Biol. 15, 5082-5091.
20. Fournier, T. M., Kamikura, D., Teng, K. and Park, M. (1996). Branching tubulogenesis but not scatter of Madin-Darby canine kidney cells requires a functional Grb2 binding site in the met receptor tyrosine kinase. J. Biol. Chem. 271, 22211-22217.
21. Glise, B., Bourbon, H. and Noselli, S. (1995). hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83, 451-461.
22. Gumbiner, B. and Simons, K. (1986). A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide J. Cell Biol. 102, 457-468.
23. c-sft causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system. EMBO J. 12, 307-314.
24. Hartmann, G., Weidner, K. M., Schwarz, H. and Birchmeier, W. (1994). The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of rat. J. Biol. Chem. 269, 21936-21939.
25. 1-chimacrin trac-1 GAP) alters the cytoskeletal and adhesive properties of fibroblasts. J. Cell Biochem. 56, 582-591.
26. Hinck, L., Nathke, J. S., Papkoff, J. and Nelson, W. J. (1994). β-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways. Trends Biochem. Sci. 19, 538-542.
27. Hodivala, K. J. and Watt, F. M. (1994). Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation. J. Cell Biol. 124, 589-600.
28. Hoschuetzky, H., Aberle, H. and Kemler, R. (1994). β-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J. Cell Biol. 127, 1375-1380.
29. Kinch, M. S., Clark, G. J., Der, C. J. and Burridge, K. (1995) Tyrosine phosphorylation regulates the adhesions of Ras-transformed breast epithelia. J. Cell Biol. 130, 461-471.
30. Klemke, R. L., Cai, S., Giannini, A. L., Gallagher, P. J., de Lanerolle, P. and Cheresh, D. A. (1997). Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol. 137, 481-492.
31. Kypta, R. M., Su, H. and Reichardt, L. F. (1997). Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex. J. Cell Biol. 134, 1519-1529
32. Lefkowith, J. B., Rogers, M., Lennartz, M. R. and Brown, E. J. (1991). Essential fatty acid deficiency impairs macrophage spreading and adherence. J. Biol. Chem. 266, 1071-1076.
33. Lewis, J. E., Wahl III, J. K., Sass, K. M., Jensen, P. J., Johnson, K. R. and Wheelock, M. J. (1997). Cross-talk between adherens junctions and desmosomes depends on plakoglobin. J. Cell Biol. 136, 919-934.
34. Lewis, J. M., Cheresh, D. A. and Schwartz, M. A. (1996). Protein kinase C regulates αvβ5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J. Cell Biol. 134, 1323-1332.
35. Li, J., Zhu, Z. and Bao, Z. (1996). Role of MacMARCKS in integrin-dependent macrophage spreading and tyrosine phosphorylation of paxillin. J. Biol. Chem. 271, 12985-12990.
36. Marshall, C. J. (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185.
37. Matsumoto, K., Ziober, B. L., Yao, C.-C. and Kramer, R. H. (1995). Growth factor regulation of integrin-mediated cell motility. Cancer Metast Rev. 14, 205-217.
38. Matsuyoshi, N., Hamaguchi, M., Taniguchi, S., Nagafuchi, A., Tsukita, S. and Takeichi, M. (1997). Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in melastatic fibroblasts. J. Cell Biol. 118, 703-714
39. Mechanic, S., Raynor, K., Hill, J. E. and Cowin, P. (1991) Desmocollins form a distinct subset of the eadherin family of cell adhesion molecules. Proc. Nat. Acad. Sci. USA 88, 4476-4480.
40. cms isoforms in human tumor cell lines. Cancer Res. 56, 2633-2640.
41. Nishizuka, Y. (1992). Intraccllular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614.
42. Pelicci, G., Giordano, S., Zhen, Z., Salcini, A. E., Lanfrancone, L., Bardelli, A., Panayotou, G., Ponzetto, C., Pelicci, P. G., Comoglio, P. M. and Waterfieid, M. D. (1995). The motogenic and mitogenic responses to HGF are amplified by the She adaptor protein. Oncogene 10 1631-1638.
43. cms and its association with c-Crkll. J. Biol. Chem. 271, 7796-7801.
44. Pignatelli, M., Liu, D., Nasim, M. M., Stamp, G. W. H., Hirano, S. and Takeichi, M. (1992). Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells. Br. J. Cancer 66, 629-634.
45. Ponzetto, C., Bardelli, A., Zhen, Z., Maina, F., dalla Zonca, P., Giordana S., Graziani, A., Panayotou, G. and Comoglio, P. M. (1994).A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family Cell 77, 261-271.
46. Reichmann, E., Schwarz, H., Deiner, E. M., Leitner, I., Eilers, M., Berger, J., Busslinger, M. and Beug, H. (1992). Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithehal-fibroblastoid cell conversion. Cell 71, 1103-1116.
47. cms associates with E-cadherin complexes Mal. Cell Biol. 14, 8333-8342.
48. Ridley, A. J., Comoglio, P. M. and Hall, A. (1995) Regulation of scatter factor/hepatocyte growth factor responses by Ras. Rac and Rho in MDCK cells. Mol. Cell Biol. 15, 1110-1122.
49. Sikamoto, M., Inu, Y., Ochiai, A., Kanai, Y., Akimotu, S. and Hirohashi, S. (1996). Formation of focal adhesion and spreading of polarized human colon cancer cells in association with tyrosine phosphorslation of paxillin in response to phorhol ester. Lab. Invest. 74, 199-208.
50. Santos, O. F. and Nigam, S. K. (1993). HGF-induced tubulogenesis and branching of epithelial cells is modulated by extracellular matrix and TGF-beta. Dev. Biol. 160, 293-302.
51. Schlaepfer, D. D., Hanks, S. K., Hunter, T. and van der Geer, P. (1994). Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase Nature 372, 786-791.
52. Schramek, H., Feifel, E., Healy, E. and Pollack. V. (1997) Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in Madin-Darby canine kidnes-C7 cells. J. Biol. Chem. 272, 11426-11433.
53. Schreiner, C., Bauer, J., Margolis, M. and Juliano, R. L. (1991). Expression and role of integrins in adhesion of human colonic carcinoma cells to extracellular matrix components. Clin. Exp. Metast. 9, 163-178.
54. Schwartz, M. A. (1993). Signaling by integrins: Implications for tumorigenesis. Cancer Res. 53, 1503-1506.
55. Schwimmer, R. and Ojakian, G. K. (1995). The α2β1 integrin regulates collagen-mediated MDCK epithelial membrane remodeling and tubule formation. J. Cell Sci. 108, 2487-2498.
56. Shibamoto, S., Hayakawa, M., Takeuchi, K., Hori, T., Miyazawa, K., Kitamura, N., Johnson, K. R., Wheelock, M. J., Matsuyoshi, N., Takeichi, M. and Ito, F. (1995). Association of p120. a tyrosine kinase substrate, with E-cadherin/catenin complexes. J. Cell Biol. 128, 949-957.
57. Shibata, T., Ochiai, A., Kanai, Y., Akimoto, S., Gotoh, M., Yasui, N., Machinami, R. and Hirohashi, S. (1996). Dominant negative inhibition of the association between β-catenin and c-erbB-2 by N-terminally deleted βcatenin suppresses the invasion and metastasis of cancer cells. Oncogene 13, 883-889.
58. Shiozaki, H., Kadowaki, T., Doki, Y., Inoue, M., Tamura, S., Oka, H., Iwazawa, T., Matsui, S., Shimaya, K., Takeichi, M. and Mori, T. (1995). Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line. Br. J. Cancer 71, 250-258.
59. Simcha, I., Geiger, B., Yehuda-Levenberg, S., Salomon, D. and Ben-Ze'ev, A. (1996). Suppression of tumorigenicity by plakoglobin: an augmenting effect of N-cadherin. J. Cell Biol. 133, 199-209.
60. Simon-Assmann, P., Leberquier, C., Molto, N., Uezato, T., Bouziges, F. and Kedinger, M. (1994). Adhesive properties and integrin expression profiles of two colonic cancer populations differing by their spreading on laminin. J. Cell Sci. 107, 577-587.
61. Stoker, M., Gherardi, E., Perryman, M. and Gray, J. (1987). Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327, 239-242.
62. Streit, M., Schmidt, R., Hilgenfeld, R. U., Thiel, E. and Kreuser, E. D. (1996). Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors. J. Mol. Med. 74, 253-268.
63. Takeda, H., Nagafuchi, A., Yonemura, S., Tsukita, S., Behrens, J. and Birchmeier, W. (1995). V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and β catenin is not required for the shift. J. Cell Biol. 131, 1839-1847.
64. Takeichi, M. (1990). Cadherins a molecular family important in selective cell-cell adhesion. Annu. Rev. Biochem. 59, 237-252.
65. Tawil, N., Wilson, P. and Carbonetto, S. (1993) Integrins in point contacts mediate cell spreading: factors that regulate integrin accumulation in point contacts vs. local contacts. J. Cell Biol. 120, 261-271.
66. Teslenko, V., Rogers, M. and Lefkowith, J. B. (1997) Macrophage arachidonate release via both the cytosolic Cal 2+1-dependent and independent phospholipases is necessars for cell spreading, Biochem. Biophys. Acta 1344, 189-199.
67. Vega-Salas, D. E., Salas, P. J. I., Gundersen, D. and Rodriguez-Boulan, E. (1987). Formation of the apical pole of epithelial (Madin-Darby canine kidney) cells: polarity of an apical protein is independent of tight junctions while segregation of a hasolateral marker requires cell-cell interactions J. Cell Biol. 104, 905-916.
68. Vermeulen, S. J., Bruyneel, E. A., Bracke, M. E., De Bruyne, G. K., Vennekens, K. M., Vleminckx, K. L., Berx, G. J., van Roy, F. M. and Mareel, M. M. (1995). Transition from the noninvasive to the invasive phenotype and loss of α-catenin in human colon cancer cells. Cancer Res. 55, 4722-4728.
69. 1 integrin-mediated cell spreading on fibronectin. J. Biol. Chem. 268, 21459-21462.
70. Wang, A. Z., Ojakian, G. K. and Nelson, W. J. (1990a) Steps in the morphogenesis of a polarized epithelium. J. Cell Sci. 95, 137-151.
71. Wang, A. Z., Ojakian, G. K. and Nelson, W. J. (1990b). Steps in the morphogenesis of a polarized epithelium: II. Disassembly and assembly of plasma membrane domains during reversal of epithelial cell polarity in multicellular epithelial (MDCK) cysts. J. Cell Sci. 95, 153-165.
72. Wary, K. K., Mainiero, F., Isakoff, S. J., Marcantonio, E. E. and Giancotti, K. G. (1996). The adaptor protein She couples a class of integrins to the control of cell cycle progression. Cell 87, 703-7-13.
73. Watabe, M., Nagafuchi, A., Tsukita, S. and Takeichi, M. (1994) Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line. J. Cell Biol. 127, 247-256.
74. Weidner, K. M., Behrens, J., Vandekerckhove, J. and Birchmeier, W. (1990). Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J. Cell Biol. 111, 2097-2108.
75. Weidner, K. M., Sachs, M. and Birchmeier, W. (1993) The Met receptor tyrosine kinase transduces motility, proliferation and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. J. Cell Biol. 121, 145-154.
76. Yebra, M., Filardo, E. J., Bayna, E. M., Kawahara, E., Becker, J. C. and Cheresh, D. A. (1995). Induction of carcinoma cell migration on vitronectin by NF-kB-dependent gene expression. Mol. Biol. Cell 6, 841-850.
77. Yoshimura, M., Nishikawa, A., Nishiura, T., Ihara, Y., Kanayama, Y., Matsuzawa, Y. and Taniguchi, N. (1995). Cell spreading in Colo 201 by staurosporin is α3β1 integrin-mediated with tyrosine phosphorylalion ol src and tensin. J. Biol. Chem. 270, 2298-2304.
78. Zhu, X. and Assoian, R- K. (1995). Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol. Biol. Cell 6, 273- 282.