Is mutated MTHFR a risk factor for neural tube defects? [2]

Lancet

Volumn 347, Issue 9002, 1996, Pages 686-687

  Posey, D L ^a   Khoury, M J ^a   Mulinare, J ^a   Adams Jr , M J ^a   Ou, C Y ^a  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID;

DIETARY INTAKE; ENZYME ACTIVITY; GENE MUTATION; HOMOZYGOSITY; HUMAN; LETTER; METHODOLOGY; NEURAL TUBE DEFECT; PRIORITY JOURNAL; RISK FACTOR;

EID: 0029968027     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)91236-2     Document Type: Letter

References (5)

1. Cy Ou Rf Stevenson Vk Brown V677T homozygosity associated with thermolabile 5,10-methylenetetrahydrofolate reductase as a risk factor for neural tube defects Am J Hum Genet 57 suppl 1995 A223
2. Nmj van der Put Rpm Steegers-Theunlssen P. Frosst Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida Lancet 346 1995 1070 1071
3. As Whitehead P. Gallagher Jl Mills A genetic defect in 5,10-methylenetetrahydrofolate reductase in neural tube defects Q J Med 88 1995 763 766
4. P. Frosst Hj Blom R. Milos A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nat Genet 10 1995 111 113
5. R. de Franchis G. Sebastio C. Mandato G. Andria P. Mastroiacovo Spina bifida, 677T→C mutation, and role of folate Lancet 346 1995 1703