메뉴 건너뛰기




Volumn 4, Issue 2, 1998, Pages 74-78

Toxicity in a double-blind, placebo-controlled pilot trial with D-penicillamine and metacycline in secondary progressive multiple sclerosis

Author keywords

D penicillamine; Metacycline; Metalloproteinase inhibition; Multiple sclerosis; Pilot study

Indexed keywords

ANTIRHEUMATIC AGENT; GELATINASE B; METACYCLINE; MONTEPLASE; PENICILLAMINE; TETRACYCLINE DERIVATIVE;

EID: 0031966055     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/135245859800400206     Document Type: Article
Times cited : (18)

References (22)
  • 1
    • 0014234078 scopus 로고
    • Esterase, peptidase and proteinase activities of human cerebrospinal fluid in multiple sclerosis
    • Rinne UK, Riekkinen P. (1968) Esterase, peptidase and proteinase activities of human cerebrospinal fluid in multiple sclerosis. Acta Neurol Scand 44: 156 - 167.
    • (1968) Acta Neurol Scand , vol.44 , pp. 156-167
    • Rinne, U.K.1    Riekkinen, P.2
  • 2
    • 0018189526 scopus 로고
    • Proteolytic enzyme activity of blood leukocytes and cerebrospinal fluid in multiple sclerosis
    • Cuzner ML, Davison AN, Rudge P. (1978) Proteolytic enzyme activity of blood leukocytes and cerebrospinal fluid in multiple sclerosis. Ann Neurol 4: 337 - 334.
    • (1978) Ann Neurol , vol.4 , pp. 337-1334
    • Cuzner, M.L.1    Davison, A.N.2    Rudge, P.3
  • 4
    • 0029907622 scopus 로고    scopus 로고
    • The expression of tissue-type plasminogen activator, matrix metalloproteases and endogenous inhibitors in the central nervous system in multiple sclerosis: Comparison of stages in lesion evolution
    • Cuzner ML et al. (1996) The expression of tissue-type plasminogen activator, matrix metalloproteases and endogenous inhibitors in the central nervous system in multiple sclerosis: comparison of stages in lesion evolution. J Neuropathol Exp Neurol 55 (12): 1194 - 1204.
    • (1996) J Neuropathol Exp Neurol , vol.55 , Issue.12 , pp. 1194-1204
    • Cuzner, M.L.1
  • 5
    • 0021647150 scopus 로고
    • Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques
    • Prineas JW, Kwon EE, Cho E, Sharer LR. (1984) Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques. Ann NY Ac Sciences 436: 11 - 32.
    • (1984) Ann NY Ac Sciences , vol.436 , pp. 11-32
    • Prineas, J.W.1    Kwon, E.E.2    Cho, E.3    Sharer, L.R.4
  • 6
    • 0023279097 scopus 로고
    • Microglia are the major cell type expressing MHC Class II in human white matter
    • Hayes GM, Woodroofe MN, Cuzner ML. (1987) Microglia are the major cell type expressing MHC Class II in human white matter. J Neurol Sciences 80: 25 - 37.
    • (1987) J Neurol Sciences , vol.80 , pp. 25-37
    • Hayes, G.M.1    Woodroofe, M.N.2    Cuzner, M.L.3
  • 7
    • 0025808816 scopus 로고
    • Purification and identification of 91-kDa neutrophil gelatinase
    • Masure S, Proost P, Van Damme J, Opdenakker G. (1991) Purification and identification of 91-kDa neutrophil gelatinase. Eur J Biochem 198: 391 - 398.
    • (1991) Eur J Biochem , vol.198 , pp. 391-398
    • Masure, S.1    Proost, P.2    Van Damme, J.3    Opdenakker, G.4
  • 8
    • 0028005697 scopus 로고
    • Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases
    • Paemen L et al. (1994) Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases. European Journal of Neurology 1: 55 - 63.
    • (1994) European Journal of Neurology , vol.1 , pp. 55-63
    • Paemen, L.1
  • 9
    • 0029867128 scopus 로고    scopus 로고
    • Matrix metalloproteinases in the normal human central nervous system, microglial nodules, and multiple sclerosis lesions
    • Maeda A, Sobel RA. (1996) Matrix metalloproteinases in the normal human central nervous system, microglial nodules, and multiple sclerosis lesions. J Neuropathol Exp Neurol 55: 300 - 309.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 300-309
    • Maeda, A.1    Sobel, R.A.2
  • 11
    • 0028328881 scopus 로고
    • Cytokine-regulated proteases in autoimmune diseases
    • Opdenakker G, Van Damme J. (1994) Cytokine-regulated proteases in autoimmune diseases. Immunology Today 15: 103 - 107.
    • (1994) Immunology Today , vol.15 , pp. 103-107
    • Opdenakker, G.1    Van Damme, J.2
  • 12
    • 0029888573 scopus 로고    scopus 로고
    • The gelatinase inhibitory activity of totracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors
    • Paemen L et al. (1996) The gelatinase inhibitory activity of totracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors. Biochemical Pharmacology 52: 105 - 111.
    • (1996) Biochemical Pharmacology , vol.52 , pp. 105-111
    • Paemen, L.1
  • 13
    • 0030052834 scopus 로고    scopus 로고
    • Human gelatinase B, a marker enzyme in rheumatoid arthritis, is inhibited by D-penicillamine: Anti-rheumatic activity by protease inhibition
    • Norga K et al. (1996) Human gelatinase B, a marker enzyme in rheumatoid arthritis, is inhibited by D-penicillamine: anti-rheumatic activity by protease inhibition. Clinical Rheumatol 15: 31 - 34.
    • (1996) Clinical Rheumatol , vol.15 , pp. 31-34
    • Norga, K.1
  • 14
    • 0029585742 scopus 로고
    • Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor D-penicillamine
    • Norga K et al. (1995) Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor D-penicillamine. Inflamm Res 44: 529 - 534.
    • (1995) Inflamm Res , vol.44 , pp. 529-534
    • Norga, K.1
  • 16
    • 0026442957 scopus 로고
    • Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders
    • Gijbels K, Masure S, Carton H, Opdenakker G. (1992) Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders. J Neuroimmonol 41: 29 - 34.
    • (1992) J Neuroimmonol , vol.41 , pp. 29-34
    • Gijbels, K.1    Masure, S.2    Carton, H.3    Opdenakker, G.4
  • 17
    • 0030055419 scopus 로고    scopus 로고
    • Cerebrospinal fluid activity of tissue plasminogen activator in patients with neurological diseases
    • Akenami FOT et al. (1996) Cerebrospinal fluid activity of tissue plasminogen activator in patients with neurological diseases. J Clin Pathol 49: 577 - 580.
    • (1996) J Clin Pathol , vol.49 , pp. 577-580
    • Akenami, F.O.T.1
  • 18
    • 0027944171 scopus 로고
    • Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases
    • Gijbels K, Galardy RE, Steinman L (1994) Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases. J Clin Invest 2177 - 2182.
    • (1994) J Clin Invest , pp. 2177-2182
    • Gijbels, K.1    Galardy, R.E.2    Steinman, L.3
  • 19
    • 0018879480 scopus 로고
    • Proteinase inhibitors suppress the development of experimental allergic encephalomyelitis
    • Brosnan CF, Cammer W, Norton WT, Bloom BR. (1980) Proteinase inhibitors suppress the development of experimental allergic encephalomyelitis. Nature 285: 235 - 237.
    • (1980) Nature , vol.285 , pp. 235-237
    • Brosnan, C.F.1    Cammer, W.2    Norton, W.T.3    Bloom, B.R.4
  • 20
    • 0029046464 scopus 로고
    • Suppression of experimental allergic encephalomyelitis by the matrix metalloproteinase inhibitor Ro31-9790
    • Hewson AK, Smith T, Leonard JP, Cuzner ML. (1995) Suppression of experimental allergic encephalomyelitis by the matrix metalloproteinase inhibitor Ro31-9790, Inflamm Res 44: 345 - 349.
    • (1995) Inflamm Res , vol.44 , pp. 345-349
    • Hewson, A.K.1    Smith, T.2    Leonard, J.P.3    Cuzner, M.L.4
  • 21
    • 0026018690 scopus 로고
    • Suppression of human neutrophil functions by tetracyclines
    • Gabler WL, Creamer HR. (1991). Suppression of human neutrophil functions by tetracyclines. J Periodont Res 26: 52 - 58.
    • (1991) J Periodont Res , vol.26 , pp. 52-58
    • Gabler, W.L.1    Creamer, H.R.2
  • 22
    • 0029584651 scopus 로고
    • Monoclonal antibodies specific for natural human neutrophil gelatinase B used for affinity purification, quantitation by two-site ELISA and inhibition of enzymatic activity
    • Paemen L, Martens E, Masure S, Opdenakker G. (1995) Monoclonal antibodies specific for natural human neutrophil gelatinase B used for affinity purification, quantitation by two-site ELISA and inhibition of enzymatic activity. Eur J Biochem 234 (3): 759 - 765.
    • (1995) Eur J Biochem , vol.234 , Issue.3 , pp. 759-765
    • Paemen, L.1    Martens, E.2    Masure, S.3    Opdenakker, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.