Human gelatinase B, a marker enzyme in rheumatoid arthritis, is inhibited by D-penicillamine: Anti-rheumatic activity by protease inhibition

Clinical Rheumatology

Volumn 15, Issue 1, 1996, Pages 31-34

  Norga, K ^a   Grillet, B ^b   Masure, S ^a   Paemen, L ^a   Opdenakker, G ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Gelatinase; Matrix metalloproteinases; Penicillamine; Plasminogen activator; Protease inhibitor; Rheumatoid arthritis

Indexed keywords

GELATINASE B; MINOCYCLINE; PENICILLAMINE;

ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NEUTROPHIL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

ANTI-BACTERIAL AGENTS; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; COLLAGENASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; HUMANS; MATRIX METALLOPROTEINASE 9; MINOCYCLINE; PENICILLAMINE; PYRIDONES; SEVERITY OF ILLNESS INDEX; SYNOVIAL FLUID;

EID: 0030052834     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02231681     Document Type: Article

References (13)

1. Opdenakker, G., Masure, S., Grillet, B., Van Damme, J. Cytokine-medialed regulation of human leucocyte gelatinases and role in arthritis. Lymphokine Cytokine Res 1991, 10, 317-324.
2. Breedveld, EC, Dijkmans, B.A.C., Matthie, H. Minocycline treatment for rheumatoid arthritis: an open dose-finding study. J Rheumatol 1990, 17, 43-46.
3. Opdenakker, G., Van Damme, J. Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer. Cytokine 1992, 4, 251-258.
4. Masure, S., Proost, P., Van Damme, J., Opdenakker, G. Purification and identification of a 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8. Eur J Biochem 1991, 198. 391-398.
5. Bunning, R.A.D., Crawford, A., Richardson, H.J., Opdenakker, G., Van Damme, J., Russell, R.G.G. Interleukin 1 preferentially stimulates the production of tissue-type plasminogen activator by human articular chondrocytes. Biochim Biophys Acta 1987, 924, 473-482.
6. Masure, S., Billiau, A., Van Damme, J., Opdenakker, G. Human hepatoma cells produce an 85kDa gelatinase regulated by phorbol 12-myristate 13-acetate. Biochim Biophys Acta 1990, 1054, 317-325.
7. Roche, P.C., Campeau, J.D., Shaw, S.T. Comparative electrophoretic analysis of human and porcine plasminogen activators in SDS-polyacrylamide gels containing plasminogen and casein. Biochim Biophys Acta 1983, 745, 82-89.
8. Blumberg, B., Bunim, J.J., Calkins, E., Pirani, C.L., Zvaifler, N.J. ARA nomenclature and classification of arthritis and rheumatism (tentative). Arthritis Rheum 1964, 7, 93-97.
9. Muijsers, A.O., van de Stadt, R.J., Henrichs, A.M.A., Ament, H.J.W., van der Korst, J.K. D-penicillamine in patients with rheumatoid arthritis. Serum levels, pharmacokinetic aspects, and correlation with clinical course and side effects. Arthritis Rheum 1984, 27, 1362-1369.
10. Vallee, B.L., Auld, D.S. Zinc coordination, function and structure of zinc enzymes and other proteins. Biochemistry 1990, 29, 5647-5659.
11. Soler, D., Nomizu, T., Brown, W.E., Chen, M., Ye, Q.Z., Van Wart, H.E., Auld, D.S. Zinc content of promatrilysin, matrilysin and the stromelysin catalytic domain. Biochem Biophys Res Commun 1994, 201, 917-923.
12. Williams, D.H., Murray E.J. Specific amino acid substitutions in human collagenase cause decreased autoproteolysis and reveal a requirement for a second zinc atom for catalytic activity. FEBS Letters 1994, 354, 267-270.
13. Van Wart, H.E., Birkedal-Hansen, H. The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc Natl Acad Sci USA 1990, 87, 5578-5582.