Disruption of a putative SH3 domain and the proline-rich motifs in the 53-kDa substrate of the insulin receptor kinase does not alter its subcellular localization or ability to serve as a substrate

Journal of Cellular Biochemistry

Volumn 68, Issue 2, 1998, Pages 139-150

  Yeh, Tammie C ^a   Li, Wenlu ^b   Keller, Gilbert André ^a   Roth, Richard A ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GENENTECH INC   (United States)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Confocal microscopy; Insulin signaling; Tyrosine kinase; Tyrosine phosphorylation

Indexed keywords

INSULIN RECEPTOR; PROTEIN P53; PROTEIN TYROSINE KINASE; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CHO CELL; CONFOCAL MICROSCOPY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROVIRUS;

3T3 CELLS; ANIMALS; BINDING SITES; CELL LINE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; MICE; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROLINE; RECEPTOR, INSULIN; SRC HOMOLOGY DOMAINS; SUBCELLULAR FRACTIONS; SUBSTRATE SPECIFICITY; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; UNIDENTIFIED RETROVIRUS;

EID: 0031964941     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19980201)68:2<139::AID-JCB1>3.0.CO;2-W     Document Type: Article

References (31)

1. Altschul S, Gish W, Miller W, Myers E, Lipman D (1990): Basic local alignment search tool. J Molec Biol 215:403-410.
2. Bairoch A, Bucher P, Hofmann K (1997): The PROSITE database, its status in 1997. Nucleic Acids Res 25:217-221.
3. Bar-Sagi D, Rotin D, Batzer A, Mandiyan V, Schlessinger J (1993): SH3 domains direct cellular localization of signaling molecules. Cell 74:83-91.
4. Bork P, Sudol M (1994): The WW domain: A signalling site in dystrophin? Trends Biomed Sci 19:531-533.
5. Cheadle C, Ivaschenko Y, South V, Searfoss G, French S, Howk R, Ricca G, Jaye M (1994): Identification of a Src Sh3 domain binding motif by screening a random phage display library. J Biol Chem 269:24034-24039.
6. Chen H, Sudol M (1995): The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. Proc Natl Acad Sci USA 92:7819-7823.
7. Clark S, Stern M, Horvitz H (1992): C. elegans cell-signaling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature 356:340-344.
8. Danielsen A, Roth R (1996): Role of the juxtamembrane tyrosine in insulin receptor mediated tyrosine phosphorylation of the p60 endogenous substrate. Endocrinology 137:5326-5331.
9. Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW (1996): Evidence for the direct interaction of the insulin-like growth factor 1 receptor with IRS-1, Shc, and Grb10. Mol Endocrinol 10:631-641.
10. Draznin B (1996): Insulin signaling network: Waiting for Copernicus. Endocrinology 137:2647-2648.
11. Erpel T, Superti-Furga G, Courtneidge S (1995): Mutational analysis of the SRC SH3 domain: The same residues of the ligand binding surface are important for intra-and intermolecular interactions. EMBO J 14:963-975.
12. Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith R, Riedel H (1996): Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus. J Biol Chem 271:8882-8886.
13. Hosomi Y, Shii K, Ogawa W, Matsuba H, Yoshida M, Okada Y, Yokono K, Kasuga M, Baba S, Roth RA (1994): Characterization of a 60 kilodalton substrate of the insulin receptor kinase. J Biol Chem 269:11498-11502.
14. Lavan BE, Lienhard GE (1993): The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase. J Biol Chem 268:5921-5928.
15. Liu F, Roth RA (1995): Grb-IR: A SH2-domain-containing protein that binds to and inhibits insulin receptor function. Proc Natl Acad Sci USA 92:10287-10291.
16. Macias M, Hyvonen M, Baraldi E, Schultz J, Sudol M, Saraste M, Oschkinat H (1996): Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide. Nature 382:646-649.
17. Milarski K, Lazar D, Wiese R, Saltiel A (1995): Detection of a 60 kDa tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of phosphatidylinositol 3-kinase. Biochem J 308: 579-583.
18. Morrione A, Valentinis B, Li S, Ooi J, Margolis B, Baserga R (1996): Grb10: A new substrate of the insulin-like growth factor I receptor. Cancer Res 56:3165-3167.
19. Musacchio A, Gibson T, Lehto V, Saraste M (1992): SH3: An abundant protein domain in search of a function. FEBS Lett 307:55-61.
20. O'Neill T, Rose T, Pillay T, Hotta K, Olefsky J, Gustafson T (1996): Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. J Biol Chem 271:22506-22513.
21. Parton R (1996): Caveolae and caveolins. Curr Opin Cell Biol 8:542-548.
22. Pear W, Nolan G, Scott M, Baltimore D (1993): Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 90:8392-8396.
23. Rickles R, Botfield M, Weng Z, Taylor J, Green O, Brugge J, Zoller M (1994): Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries. EMBO J 13:5598-5604.
24. Saksela K, Cheng G, Baltimore D (1995): Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO J 14:484-491.
25. Sargiacomo M, Sudol M, Tang Z, Lisanti M (1993): Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells. J Cell Biol 122:789-907.
26. Song K, Lis S, Okamoto T, Quilliam L, Sargiacomo M, Lisanti M (1996): Co-purification and direct interaction of ras with caveolin, an integral membrane protein of caveolae microdomains. J Biol Chem 271:9690-9697.
27. Sparks A, Rider J, Hoffman N, Fowlkes D, Quilliam L, Kay B (1996): Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCγ, Crk, and Grb2. Proc Natl Acad Sci USA 93:1540-1544.
28. Staub O, Dho S, Henry P, Correa J, Ishikawa T, McGlade J, Rotin D (1996): WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial N1+ channel deleted in Liddle's syndrome. EMBO J 15:2371-2380.
29. Sudol M, Chen H, Bougeret C, Einbond A, Bork P (1995): Characterization of a novel protein-binding module: The WW domain. FEBS Lett 369:67-71.
30. Sung CK, Goldfine ID (1992): Phosphatidylinositol-3-kinase is a non-tyrosine phosphorylated member of the insulin receptor signalling complex. Biochem Biophys Res Commun 189:1024-1030.
31. Yeh TC, Ogawa W, Danielsen AG, Roth RA (1996): Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase. J Biol Chem 271:2921-2928.