-
1
-
-
0028278931
-
The insulin receptor: Structure, function, and signaling
-
Lee J, Pilch PF 1994 The insulin receptor: structure, function, and signaling. Am J Physiol 266:C319-334
-
(1994)
Am J Physiol
, vol.266
-
-
Lee, J.1
Pilch, P.F.2
-
2
-
-
0021924895
-
The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signaling
-
Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, Ou J, Masiarz F, Kan YW, Goldfine ID, Roth RA, Rutter WJ 1985 The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signaling. Cell 40:747-758
-
(1985)
Cell
, vol.40
, pp. 747-758
-
-
Ebina, Y.1
Ellis, L.2
Jarnagin, K.3
Edery, M.4
Graf, L.5
Clauser, E.6
Ou, J.7
Masiarz, F.8
Kan, Y.W.9
Goldfine, I.D.10
Roth, R.A.11
Rutter, W.J.12
-
3
-
-
0028582185
-
Crystal structure of the tyrosine kinase domain of the human insulin receptor
-
Hubbard SR, Wei L, Ellis L, Hendrickson WA 1994 Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372:746-54
-
(1994)
Nature
, vol.372
, pp. 746-754
-
-
Hubbard, S.R.1
Wei, L.2
Ellis, L.3
Hendrickson, W.A.4
-
4
-
-
0028278339
-
Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase
-
Pang L, Milarski KL, Ohmichi M, Takata Y, Olefsky JM, Saltiel AR 1994 Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase. J Biol Chem 269:10604-10608
-
(1994)
J Biol Chem
, vol.269
, pp. 10604-10608
-
-
Pang, L.1
Milarski, K.L.2
Ohmichi, M.3
Takata, Y.4
Olefsky, J.M.5
Saltiel, A.R.6
-
5
-
-
0026808361
-
Characterization of insulin-stimulated protein serine/threonine kinases in CHO cells expressing human insulin receptors with point and deletion mutations
-
Dickens M, Chin JE, Roth RA, Ellis L, Denton RM, Tavare JM 1992 Characterization of insulin-stimulated protein serine/threonine kinases in CHO cells expressing human insulin receptors with point and deletion mutations. Biochem J 287:201-209
-
(1992)
Biochem J
, vol.287
, pp. 201-209
-
-
Dickens, M.1
Chin, J.E.2
Roth, R.A.3
Ellis, L.4
Denton, R.M.5
Tavare, J.M.6
-
6
-
-
0028012445
-
Direct activation of the phosphatidylinositol 3′-kinase by the insulin receptor
-
Van Horn DJ, Myers, Jr, MG, Backer JM 1994 Direct activation of the phosphatidylinositol 3′-kinase by the insulin receptor. J Biol Chem 269:24-32
-
(1994)
J Biol Chem
, vol.269
, pp. 24-32
-
-
Van Horn, D.J.1
Myers Jr., M.G.2
Backer, J.M.3
-
7
-
-
0028036795
-
Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP
-
Staubs PA, Reichart DR, Saltiel AR, Milarski KL, Maegawa H, Berhanu P, Olefsky JM, Seely BL 1994 Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP. J Biol Chem 269:27186-27192
-
(1994)
J Biol Chem
, vol.269
, pp. 27186-27192
-
-
Staubs, P.A.1
Reichart, D.R.2
Saltiel, A.R.3
Milarski, K.L.4
Maegawa, H.5
Berhanu, P.6
Olefsky, J.M.7
Seely, B.L.8
-
8
-
-
0028006743
-
Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells
-
Levy-Toledano R, Taouis M, Blaettler DH, Gorden P, Taylor SI 1994 Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells. J Biol Chem 269:31178-31182
-
(1994)
J Biol Chem
, vol.269
, pp. 31178-31182
-
-
Levy-Toledano, R.1
Taouis, M.2
Blaettler, D.H.3
Gorden, P.4
Taylor, S.I.5
-
9
-
-
0023814924
-
Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity
-
White MF, Livingston JN, Backer JM, Lauris V, Dull TJ, Ullrich A, Kahn CR 1988 Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity. Cell 54:641-649
-
(1988)
Cell
, vol.54
, pp. 641-649
-
-
White, M.F.1
Livingston, J.N.2
Backer, J.M.3
Lauris, V.4
Dull, T.J.5
Ullrich, A.6
Kahn, C.R.7
-
10
-
-
0027185238
-
Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor
-
Kaburagi Y, Momomura K, Yamamoto-Honda R, Tobe K, Tamori Y, Sakura H, Akanuma Y, Yazaki Y, Kadowaki T 1993 Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor. J Biol Chem 268:16610-16622
-
(1993)
J Biol Chem
, vol.268
, pp. 16610-16622
-
-
Kaburagi, Y.1
Momomura, K.2
Yamamoto-Honda, R.3
Tobe, K.4
Tamori, Y.5
Sakura, H.6
Akanuma, Y.7
Yazaki, Y.8
Kadowaki, T.9
-
11
-
-
0025819773
-
Cytoplasmic juxtamembrane region of the insulin receptor: A critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells
-
Backer JM, Schroeder GG, Cahill DA, Ullrich A, Siddle K, White MF 1991 Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells. Biochemistry 30:6366-6372
-
(1991)
Biochemistry
, vol.30
, pp. 6366-6372
-
-
Backer, J.M.1
Schroeder, G.G.2
Cahill, D.A.3
Ullrich, A.4
Siddle, K.5
White, M.F.6
-
12
-
-
0025995581
-
Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin
-
Kapeller R, Chen KS, Yoakim M, Schaffhausen BS, Backer J, White MF, Cantley LC, Ruderman NB 1991 Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. Mol Endocrinol 5:769-777
-
(1991)
Mol Endocrinol
, vol.5
, pp. 769-777
-
-
Kapeller, R.1
Chen, K.S.2
Yoakim, M.3
Schaffhausen, B.S.4
Backer, J.5
White, M.F.6
Cantley, L.C.7
Ruderman, N.B.8
-
13
-
-
0025788157
-
The role of insulin receptor autophosphorylation in signal transduction
-
Murakami MS, Rosen OM 1991 The role of insulin receptor autophosphorylation in signal transduction. J Biol Chem 266:22653-22660
-
(1991)
J Biol Chem
, vol.266
, pp. 22653-22660
-
-
Murakami, M.S.1
Rosen, O.M.2
-
14
-
-
0027958425
-
Functional domains of the insulin receptor responsible for chemotactic signaling
-
Yenush L, Kundra V, White MF, Zetter BR 1994 Functional domains of the insulin receptor responsible for chemotactic signaling. J Biol Chem 269:100-104
-
(1994)
J Biol Chem
, vol.269
, pp. 100-104
-
-
Yenush, L.1
Kundra, V.2
White, M.F.3
Zetter, B.R.4
-
15
-
-
0029121174
-
The role of the NPXY motif in the insulin receptor in tyrosine phosphorylation of insulin receptor substrate-1 and Shc
-
Kaburagi Y, Yamamoto-Honda R, Tobe K, Ueki K, Yachi M, Akanuma Y, Stephens RM, Kaplan D, Yazaki Y, Kadowaki T 1995 The role of the NPXY motif in the insulin receptor in tyrosine phosphorylation of insulin receptor substrate-1 and Shc. Endocrinology 136:3437-3443
-
(1995)
Endocrinology
, vol.136
, pp. 3437-3443
-
-
Kaburagi, Y.1
Yamamoto-Honda, R.2
Tobe, K.3
Ueki, K.4
Yachi, M.5
Akanuma, Y.6
Stephens, R.M.7
Kaplan, D.8
Yazaki, Y.9
Kadowaki, T.10
-
16
-
-
0027969225
-
Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system
-
O'Neill TJ, Craparo A, Gustafson TA 1994 Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system. Mol Cell Biol 14:6433-6442
-
(1994)
Mol Cell Biol
, vol.14
, pp. 6433-6442
-
-
O'Neill, T.J.1
Craparo, A.2
Gustafson, T.A.3
-
17
-
-
13344278677
-
Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphoryation by insulin in vivo
-
Isakoff SJ, Yu Y-P, Su Y-C, Blaikie P, Yajnik V, Rose E, Weidner KM, Sachs M, Margolis B, Skolnik EY 1996 Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphoryation by insulin in vivo. J Biol Chem 271:3959-3962
-
(1996)
J Biol Chem
, vol.271
, pp. 3959-3962
-
-
Isakoff, S.J.1
Yu, Y.-P.2
Su, Y.-C.3
Blaikie, P.4
Yajnik, V.5
Rose, E.6
Weidner, K.M.7
Sachs, M.8
Margolis, B.9
Skolnik, E.Y.10
-
18
-
-
0030010590
-
Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor
-
Eck MJ, Dhe-Paganon S, Trub T, Nolte RT, Shoelson SE 1996 Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell 85:1-20
-
(1996)
Cell
, vol.85
, pp. 1-20
-
-
Eck, M.J.1
Dhe-Paganon, S.2
Trub, T.3
Nolte, R.T.4
Shoelson, S.E.5
-
19
-
-
0028888604
-
The PTB domain: A new protein module implicated in signal transduction
-
Van der Geer P, Pawson T 1995 The PTB domain: a new protein module implicated in signal transduction. Trends Biochem Sci 20:277-280
-
(1995)
Trends Biochem Sci
, vol.20
, pp. 277-280
-
-
Van Der Geer, P.1
Pawson, T.2
-
20
-
-
0028947757
-
Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase Cγ-1
-
Richard S, Yu D, Blumer KJ, Hausladen D, Olszowy MW, Connelly PA, Shaw AS 1995 Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase Cγ-1. Mol Cell Biol 15:186-197
-
(1995)
Mol Cell Biol
, vol.15
, pp. 186-197
-
-
Richard, S.1
Yu, D.2
Blumer, K.J.3
Hausladen, D.4
Olszowy, M.W.5
Connelly, P.A.6
Shaw, A.S.7
-
21
-
-
0028911418
-
Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells
-
Ogawa W, Hosomi Y, Roth RA 1995 Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells. Endocrinology 136:476-481
-
(1995)
Endocrinology
, vol.136
, pp. 476-481
-
-
Ogawa, W.1
Hosomi, Y.2
Roth, R.A.3
-
22
-
-
0027417484
-
The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase
-
Lavan BE, Lienhard GE 1993 The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase. J Biol Chem 268:5921-5928
-
(1993)
J Biol Chem
, vol.268
, pp. 5921-5928
-
-
Lavan, B.E.1
Lienhard, G.E.2
-
23
-
-
0027055333
-
Phosphatidylinositol-3-kinase is a non-tyrosine phosphorylated member of the insulin receptor signaling complex
-
Sung CK, Goldfine ID 1992 Phosphatidylinositol-3-kinase is a non-tyrosine phosphorylated member of the insulin receptor signaling complex. Biochem Biophys Res Commun 189:1024-1030
-
(1992)
Biochem Biophys Res Commun
, vol.189
, pp. 1024-1030
-
-
Sung, C.K.1
Goldfine, I.D.2
-
24
-
-
0029995773
-
A 60-kilodalton protein in rat hepatoma cells overexpressing insulin receptor was tyrosine phosphorylated and associated with Syp, phosphatidylinositol 3-kinase, and Grb2 in an insulin-dependent manner
-
Zhang-Sun G, Yang C-R, Viallet J, Feng G-S, Bergeron JJM, Posner BI 1996 A 60-kilodalton protein in rat hepatoma cells overexpressing insulin receptor was tyrosine phosphorylated and associated with Syp, phosphatidylinositol 3-kinase, and Grb2 in an insulin-dependent manner. Endocrinology 137:2649-2658
-
(1996)
Endocrinology
, vol.137
, pp. 2649-2658
-
-
Zhang-Sun, G.1
Yang, C.-R.2
Viallet, J.3
Feng, G.-S.4
Bergeron, J.J.M.5
Posner, B.I.6
-
25
-
-
0030020789
-
Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase
-
Yen TC, Ogawa W, Danielsen AG, Roth RA 1996 Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase. J Biol Chem 271:2921-2928
-
(1996)
J Biol Chem
, vol.271
, pp. 2921-2928
-
-
Yen, T.C.1
Ogawa, W.2
Danielsen, A.G.3
Roth, R.A.4
-
26
-
-
0022551057
-
Mapping surface structures of the human insulin receptor with monoclonal antibodies: Localization of the main immunogenic regions to the receptor kinase domain
-
Morgan DO, Roth RA 1986 Mapping surface structures of the human insulin receptor with monoclonal antibodies: Localization of the main immunogenic regions to the receptor kinase domain. Biochemistry 25:1364-1371
-
(1986)
Biochemistry
, vol.25
, pp. 1364-1371
-
-
Morgan, D.O.1
Roth, R.A.2
-
27
-
-
0028341869
-
Characterization of a 60 kilodalton substrate of the insulin receptor kinase
-
Hosomi Y, Shii K, Ogawa W, Matsuba H, Yoshida M, Okada Y, Yokono K, Kasuga M, Baba S, Roth RA 1994 Characterization of a 60 kilodalton substrate of the insulin receptor kinase. J Biol Chem 269:11498-11502
-
(1994)
J Biol Chem
, vol.269
, pp. 11498-11502
-
-
Hosomi, Y.1
Shii, K.2
Ogawa, W.3
Matsuba, H.4
Yoshida, M.5
Okada, Y.6
Yokono, K.7
Kasuga, M.8
Baba, S.9
Roth, R.A.10
-
29
-
-
0028006378
-
Enzyme-linked immunosorbent assay method for human autophosphorylated insulin receptor. Applicability to insulin-resistant states
-
Hagino H, Shii K, Yokono K, Matsuba H, Yoshida M, Hosomi Y, Okada Y, Kishimoto M, Hozumi T, Ishida Y, Kazumi T, Nishimura R, Kasuga M, Baba S 1994 Enzyme-linked immunosorbent assay method for human autophosphorylated insulin receptor. Applicability to insulin-resistant states. Diabetes 43:274-80
-
(1994)
Diabetes
, vol.43
, pp. 274-280
-
-
Hagino, H.1
Shii, K.2
Yokono, K.3
Matsuba, H.4
Yoshida, M.5
Hosomi, Y.6
Okada, Y.7
Kishimoto, M.8
Hozumi, T.9
Ishida, Y.10
Kazumi, T.11
Nishimura, R.12
Kasuga, M.13
Baba, S.14
-
30
-
-
0022494971
-
Replacement of insulin receptor tyrosine residues (1162 and 1163) by site-directed mutagenesis compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose
-
Ellis L, Clauser E, Morgan DO, Edery M, Roth RA, Rutter WJ 1986 Replacement of insulin receptor tyrosine residues (1162 and 1163) by site-directed mutagenesis compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell 45:721-732
-
(1986)
Cell
, vol.45
, pp. 721-732
-
-
Ellis, L.1
Clauser, E.2
Morgan, D.O.3
Edery, M.4
Roth, R.A.5
Rutter, W.J.6
-
31
-
-
0023392945
-
High-efficiency transformation of mammalian cells by plasmid DNA
-
Chen C, Okayama H 1987 High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752
-
(1987)
Mol Cell Biol
, vol.7
, pp. 2745-2752
-
-
Chen, C.1
Okayama, H.2
-
32
-
-
0027954632
-
Activation of protein kinase Cα inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1
-
Chin JE, Liu F, Roth RA 1994 Activation of protein kinase Cα inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1. Mol Endocrinol 8:51-58
-
(1994)
Mol Endocrinol
, vol.8
, pp. 51-58
-
-
Chin, J.E.1
Liu, F.2
Roth, R.A.3
-
33
-
-
0027277107
-
Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor
-
Feener EP, Backer JM, King GL, Wilden PA, Sun XJ, Kahn CR, White MF 1993 Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor. J Biol Chem 268:11256-11264
-
(1993)
J Biol Chem
, vol.268
, pp. 11256-11264
-
-
Feener, E.P.1
Backer, J.M.2
King, G.L.3
Wilden, P.A.4
Sun, X.J.5
Kahn, C.R.6
White, M.F.7
-
34
-
-
0027157576
-
Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamembrane sites
-
Kohanski RA 1993 Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamembrane sites. Biochemistry 32:5773-5780
-
(1993)
Biochemistry
, vol.32
, pp. 5773-5780
-
-
Kohanski, R.A.1
-
35
-
-
0029973293
-
Evidence for the direct interaction of the insulin-like growth factor 1 receptor with IRS-1, Shc, and Grb10
-
Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW 1996 Evidence for the direct interaction of the insulin-like growth factor 1 receptor with IRS-1, Shc, and Grb10. Mol Endocrinol 10:631-641
-
(1996)
Mol Endocrinol
, vol.10
, pp. 631-641
-
-
Dey, B.R.1
Frick, K.2
Lopaczynski, W.3
Nissley, S.P.4
Furlanetto, R.W.5
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