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Cundell D, Masure HR, Tuomanen EI: The molecular basis of pneumococcal infection: a hypothesis. Clin Infect Dis 1995, 21(suppl 3):S204-S212. An extremely interesting hypothesis of the critical steps in the pathogenesis of pneumococcal infection attempting to explain mechanisms of the transition of the organism from commensal to invasive pathogen.
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46
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47
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Usobiaga P, Medrano FJ, Gasset M, Garcia JL, Saiz JL, Rivas G, Laynez J, Menendez M: Structural organization of the major autolysin from Streptococcus pneumoniae. J Biol Chem 1996, 271:6832-6838.
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48
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Smith RP, Lipworth BJ, Cree IA, Spiers EM, Winter JH: C-reactive protein. A clinical marker in community-acquired penumonia. Chest 1995, 108:1288-1291. A study in patients with community-acquired pneumonia suggesting that C-reactive protein is a sensitive clinical marker of pneumonia.
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49
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Szalai AJ, Briles DE, Volanakis JE: Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice. J Immunol 1995, 155:2557-2563. An experimental study demonstrating that endogenously synthesized C-reactive protein is significantly protective against fatal pneumococcal infection.
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50
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Lawrence E, van Eeden S, English D, Hogg JC: Polymorphonuclear leukocyte (PMN) migration in streptococcal pneumonia: comparison of older PMN with those recently released from the marrow. Am J Respir Cell Molec Biol 1996, 14:217-224. An interesting experimental study of pneumococcal pneumonia. Polymorphonuclear leucocytes released from the bone marrow sequester normally in the circulation but may be slow to migrate into the airspaces at the site of inflammation.
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Am J Respir Cell Molec Biol
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Lawrence, E.1
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51
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52
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Ubukata K, Asahi Y, Yamane A, Konno M: Combinational detection of autolysin and penicillin-binding protein 2B genes of Streptococcus pneumoniae by PCR. J Clin Microbiol 1996, 34:592-596.
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Minton EJ, Macfarlane JT: Antibiotic resistant Streptococcus pneumoniae. Thorax 1996, 51(suppl 2):S45-S50.
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Pankuch GA, Visalli MA, Jacobs MR, Appelbaum PC: Activities of oral and parenteral agents against penicillin-susceptible and - resistant pneumococci. Antimicrob Agents Chemother 1995, 39:1499-1504.
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55
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Barry AL, Brown SD, Novick WJ: In-vitro activities of cefotaxime, ceftriaxone, ceftazidime, cefpirome, and penicillin against Streptococcus pneumoniae isolates. Antimicrobv Agents Chemother 1995, 399:2193-2196.
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56
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Girard AE, Girard D, Gootz TD, Faiella JA, Cimochowski CR: In-vivo efficacy of trovafloxacin (CP-99 219), a new quinolone with extended activities against gram-positive pathogens, Strepococcus pneumoniae, and Bacteroides fragilis. Antimicrob Agents Chemother 1995, 39:2210-2216.
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58
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Aubier M, Lode H, Gialdroni-Grassi G, Huchon G, Hosie J, Legakis N, Regamey C, Segev S, Vester R, Wijnands WJ, Tolstuchow N: Sparfloxacin for the treatment of community-acquired pneumonia: a pooled data analysis of two studies. J Antimicrob Chemother 1996, 37(Suppl A):73-82.
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59
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Friedland IR: Comparison of the response to antimicrobial therapy of penicillin-resistant and penicillin-susceptible pneumococcal disease. Pediatr Infect Dis ,1995, 14:885-890. This study showed that intermediately penicillin-resistant pneumococcal pneumonia in children responds clinically in a similar fashion to disease caused by penicillin-susceptible strains.
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Goldstein FW, Acar JF, and The Alexander Project Collaborative Group: Antimicrobial resistance among lower respiratory tract isolates of Streptococcus pneumoniae: results of a 1992-1993 Western Europe and USA collaborative surveillance study. J Antimicrob Chemother 1996, 38(suppl A):71-84.
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Klugman KP: The clinical relevance of in-vitro resistance to penicillin, ampicillin, amoxycillin and alternative agents, for the treatment of community-acquired pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis. J Antimicrob Chemother 1996, 38(Suppl A):133-140.
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Jacobs RF, Kaplan SL, Schutze GE, Dajanl AS, Leggiadro RJ, Rim C-S Puri SK: Relationship of MICs to efficacy of cefotaxime in treatment of Streptococcus pneumonias infections. Antimicrob Agents Chemother 1996, 40:895-898.
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Knudsen JD, Frimodt-Mller N, Espersen F: Experimental Streptococcus pneumoniae infection in mice for studying correlation of in-vitro and in-vivo activities of penicillin against pneumococci with various susceptibilities to penicillin. Antimicrob Agents Chemother 1995, 39:1253-1258.
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Shahid NS, Steinhoff MC, Hogue SS, Begum T, Thompson C, Siber GR: Serum, breast milk, and infant antibody after maternal immunisation with pneumococcal vaccine. Lancet 1995, 346:1252-1257. This study shows that maternal immunization produces strong antibody responses that are transferred to infants.
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Konradsen HB: Quality and avidity of pneumococcal antibodies before and up to five years after pneumococcal vaccination of elderly persons. Clin Infect Dis 1995, 21:161-620.
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Farr BM, Johnston BL, Cobb DK, Fisch MJ, Germanson TP, Adal KA, AngliM AM: Preventing pneumococcal bacteremia in patients at risk. Arch Intern Med 1995, 155:2336-2340.
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Centers for Disease Control: Increasing pneumococcal vaccination rates among patients of a National Health-Care Alliance - United States, 1993. MMWR Morb Mortal Wkly Rep 1995, 44:741-744.
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Alonso De Velasco E, Dekker BAT, Verheul AFM, Feldman RD, Verhorf J, Snippe H: Anti-polysaccharide immunoglobulin isotype levels and opsonic activity of antisera: relationships with protection against Streptococcus pneumoniae infection in mice. J Infect Dis 1995, 172:562-565.
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74
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Mascart-Lemone F, Grard M, Libin M, Crusiaux A, Franchioly P, Lambrechts A, Goldman M, Clumeck N: Differential effect of human immunodeficiency virus infection on the IgA and IgG antibody response to pneumococcal vaccine. J Infect Dis 1995, 172:1253-1260.
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75
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Ahmed F, Steinhoff MC, Rodriguez-Barradas MC, Hamilton RG, Musher DM, Nelson KE: Effect of human immunodeficiency virus type 1 infection on the antibody response to a glycoprotein pneumococcal vaccine: results from a randomized trial. J Infect Dis 1996 173:83-90.
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J Infect Dis
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Comparison of the safety and immunogenicity of a pneumococcal conjugate with a licensed polysacharide vaccine in human immunodeficiency virus and non-human immunodeficiency virus-infected children
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King JC, Vink PE, Farley JJ, Parks MM, Smilie M, Madore D, Lichenstein R, Malinoski F: Comparison of the safety and immunogenicity of a pneumococcal conjugate with a licensed polysacharide vaccine in human immunodeficiency virus and non-human immunodeficiency virus-infected children. Pediatr Infect Dis J 1996, 15:192-196.
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77
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Tart RC, McDaniel LS, Ralph BA, Briles DE: Truncated Strepococcus pneumoniae PspA molecules elicit cross-protective immunity against pneumococcal challenge in mice. J Infect Dis 1996, 173:380-386. This study showed that cross-reactive antibodies against a protein-based vaccine protected mice against heterologous challenge.
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