The PEA3 protein of the Ets oncogene family is a putative transcriptional modulator of the mouse epididymis-specific glutathione peroxidase gene gpx5

Molecular Reproduction and Development

Volumn 49, Issue 2, 1998, Pages 131-140

  Drevet, Joel R ^a   Lareyre, Jean Jacques ^a,b   Schwaab, Veronique ^a   Vernet, Patrick ^a   Dufaure, Jean Pierre ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Caput epididymidis; Ets trans acting factor; Scavenger enzymes; Tissue specific expression

Indexed keywords

ANDROGEN; CHLORAMPHENICOL ACETYLTRANSFERASE; DNA; DNA BINDING PROTEIN; GLUTATHIONE PEROXIDASE; TRANS ACTING FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; EPIDIDYMIS; GENE DELETION; GENE EXPRESSION; MALE; MOUSE; MULTIGENE FAMILY; NONHUMAN; NORTHERN BLOTTING; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANDROGENS; ANIMALS; ANIMALS, NEWBORN; DNA-BINDING PROTEINS; EPIDIDYMIS; GENETIC VECTORS; GLUTATHIONE PEROXIDASE; MALE; MICE; ORGAN SPECIFICITY; PROMOTER REGIONS (GENETICS); RETROVIRIDAE PROTEINS, ONCOGENIC; RNA, MESSENGER; TESTICULAR HORMONES; TESTIS; TRANSCRIPTION FACTORS;

ANIMALIA; CAPUT; MURINAE; RODENTIA; VERTEBRATA;

EID: 0031962149     PISSN: 1040452X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2795(199802)49:2<131::AID-MRD4>3.0.CO;2-Q     Document Type: Article

References (51)

1. Abe K, Takano H, Ito T (1983): Ultrastructure of the mouse eididymal duct with special reference to the regional differences of the principal cells. Arch. Histol Jpn 46:51-68.
2. Brigelius-Flohé L, Aumann KD, Blocker H, Gross G, Kiess M, Kloppel KD, Maiorino M, Roveri A, Schuckelt R, Ursini F, Windenger E, Flohé L (1994): Phospholipid-hydroperoxide glutathione peroxidase: Genomic DNA, cDNA and deduced amino acid sequence. J Biol Chem 269:7342-7348.
3. Chambers I, Frampton J, Goldfarb P, Affara N, McBain W and Harrison PR (1986): The structure of the mouse glutathione peroxidase gene: The selenocysteine in the active site is encoded by the termination codon, TGA. EMBO J 5:1221-1227.
4. Chambers I, Harrison P (1988): In "Oxyradicals in Molecular Biology and Pathology." New York: Alan R. Liss, pp 289-300.
5. Chen C, Okayama H (1987): High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752.
6. Chu FF, Esworthy RS, Doroshow JH, Doan K, Liu XF (1992): Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, breast in humans and rodents. Blood 79:3233-3238.
7. Chu FF (1994): The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. Cytogenet Cell Genet 66:96-98.
8. Cornwall GA, Hann SR (1995): Specialized gene expression in the epididymis. J Androl 16:379-383.
9. Crépieux P, Coll J, Stehelin D (1994): The Ets family of proteins: Weak modulators of gene expression in quest for transcriptional partners. Crit Rev Oncol 5:615-638.
10. Drevet JR, Skeiky YAW, Iatrou K (1994): GATA-type zinc finger motif containing sequences and chorion gene transcription factors of the silkworm Bombyx mori. J Biol Chem 269:10660-10667.
11. Dufaure J-P, Lareyre J-J, Schwaab V, Mattei M-G, Drevet JR (1996): Structural organization, chromosomal localization, expression and phylogenetic evaluation of mouse glutathione peroxidase encoding genes. C R Acad Sci 319:559-568.
12. Faisst S, Meyer S (1992): Compilation of vertebrate-encoded transcriptions factors. Nucleic Acids Res 20:3-26.
13. Faure J, Ghyselinck NB, Jimenez C, Dufaure J-P (1991): Specific distribution of messenger ribonucleic acids for 24-kilodalton proteins in the mouse epididymis as revealed by in situ hybridization: Developmental expression and regulation in the adult. Biol Reprod 44:13-22.
14. Flohé L (1982): Glutathione peroxidase brought into focus. In WA Pryor (ed): "Free Radicals in Biology," Vol 5. New York: Academic Press, pp 223-253.
15. Gauthier JM, Bourachot B, Doucas V, Yaniv M, Moreau-Gachelin F (1993): Functional interference between the Spi-1/PU.1 oncoprotein and steroid hormone or vitamin receptors. EMBO J 12:5089-5096.
16. Ghyselinck NB, Jimenez C, Courty Y, Dufaure J-P (1989): Androgen-dependent messenger RNA(s) related to secretory proteins in the mouse epididymis. J Reprod Fertil 85:631-639.
17. Ghyselinck NB, Dufaure I, Lareyre J-J, Rigaudière N, Mattéi M-G, Dufaure J-P (1993): Structural organization and regulation of the gene for androgen-dependent glutathione peroxidase-like protein specific to the mouse epididymis. Mol Endocrinol 7:258-272.
18. Halliwell B, Gutteridge JMC (1989): "Free Radicals in Biology and Medicine." Oxford, England: Clarendon Press.
19. Herbomel P, Bourachot B, Yaniv M (1984): Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma. Cell 39:653-662.
20. Hinton BT, Palladino MA, Rudolph D, Labus JC (1995): The epididymis as protector of maturing spermatozoa. Reprod Fertil Dev 7:731-745.
21. Himeno S, Takekawa A, Toyoda H, Imura N (1993): Tissue-specific expression of glutathione peroxidase gene in guinea pigs. Biochem Biophys Acta 1173:283-288.
22. Lareyre J-J, Claessens F, Rombauts W, Dufaure J-P, Drevet JR (1997): Characterization of an androgen response element (ARE) within the promoter of the epididymis-specific murine glutathione peroxidase 5 gene. Mol Cell Endocrinol 129:33-46.
23. Maiti S, Doskow J, Li S, Nhim RP, Lindsey JS, Wilkinson MF (1996): The Pem homeobox gene: Androgen-dependent and-independent promoters and tissue-specific alternative RNA splicing. J Biol Chem 271:17536-17546.
24. Manley JL, Fine A, Cano A, Sharp PA, Gefter ML (1980): DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract. Proc Natl Acad Sci USA 77:3855.
25. Marzluff WF, Huang RCC (1984): In BD Hames, SJ Higgins (eds): "Transcription and Translation: A Paractical Approach. Washington: IRL Press.
26. Nerlov C, DeCesare D, Pergola F, Caracciolo A, Blasi F, Johnsen M, Verde P (1992): A regulatory element that mediates cooperation between a PEA3-AP1 element and an AP1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells. EMBO J 11:4573-4582.
27. Newcomer ME, Ong DE (1990): Purification and crystallisation of an RA-binding protein from rat epididymis: Identity with the major androgen-dependent epididymal proteins. J Biol Chem 265:12876-12879.
28. O'Neill EM, Rebay I, Tjian R, Rubin GM (1994): The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78:137-147.
29. Ong DE, Chytil F (1988): Presence of novel RA-binding proteins in the lumen of rat epididymis. Arch Biochem Biophys 267:474-478.
30. O'Prey J, Ramsay S, Chambers I, Harrison PR (1993): Transcriptional upregulation of mouse cytosolic glutathione peroxidase gene in erythroid cells is due to a tissue-specific 3′ enhancer containing functionally important CACC/GT motifs and binding sites for GATA and Ets transcription factors. Mol Cell Biol 13:6290-6303.
31. Orgebin-Crist M-C, Danzo BJ, Davies J (1975): Endocrine control of the development at maintenance of sperm fertilizing ability in the epididymis. In RO Greep, WD Hamilton (eds): "Handbook of Physiology," vol 5, sec 7. Washington: American Physiological Society, p 319.
32. Pappas SR, Newcomer ME, Ong DE (1993): Endogenous retinoids in rat epididymal tissue and rat and human spermatozoa. Biol Reprod 48:235-247.
33. Prandini MH, Martin F, Theenon D, Uzan G (1996): The tissue-specific transcriptional regulation of the megakaryotic glycoprotein IIb gene is controlled by interactions between a repressor and positive cis-acting elements. Blood 88:2062-2070.
34. Ptashne M (1986): Gene regulation by proteins acting nearby and at a distance. Nature 322:697-699.
35. Ptashne M. (1988): How eukaryotic transcriptional activators work. Nature 335:683-689.
36. Roche C, Williams DL, Khalife J, Lepresle T, Capron A, Pierce RJ (1994): Cloning and characterization of the gene encoding Schistosoma mansoni glutathione peroxidase. Gene 138:149-152.
37. Roveri A, Maiorino M, Nisii C, Ursini F (1994): Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrian membranes. Biochem Biophys Acta 1208:211-221.
38. Sambrook J, Fritsch EF, Maniatis T (1989): In "Molecular Cloning: A Laboratory Manual," 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
39. Schowalter DB, Sommer SS (1989): The generation of radiolabelled DNA and RNA probes with polymerase chain reaction. Anal Biochem 177:90-94.
40. Schwaab V, Baud E, Ghyselinck NB, Mattéi M-G, Dufaure J-P, Drevet JR (1995): Cloning of the mouse gene encoding plasma glutathione peroxidase: Organization, sequence and chromosomal localization. Gene 167:25-31.
41. Schneikert J, Peterziel H, Defossez PA, Klocker H, Delaunoit Y, Cato ACB (1996): Androgen receptor-Ets protein interaction is a novel mechanism for steroid hormone-mediated down-modulation of matrix metalloproteinase expression. J Biol Chem 271:23907-23913.
42. Sunde RA, Hoekstra WG (1980): Structure, synthesis and function of glutathione peroxidase. Nutr Rev 38:265-273.
43. Vernet P, Rigaudière N, Ghyselinck NB, Dufaure J-P, Drevet JR (1996): In vitro expression of a mouse tissue-specific glutathione-peroxidase-like protein lacking the selenocysteine can protect stably transfected mammalian cells against oxidative damage. Biochem Cell Biol 74:125-131.
44. Vernet P, Faure J, Dufaure J-P, Drevet JR (1997): Tissue- and developmental distribution, dependance upon testicular factors and attachment to spermatozoa of GPX5, a murine epididymis-specific glutathione peroxidase. Mol Reprod Dev 46:1-12.
45. Wasylyk C, Flores P, Gutman A, Wasylyk B (1989): PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes. EMBO J 8:3371-3378.
46. Winer MA, Wadewitz AG, Wolgemuth DJ (1993): Members of the raf gene family exhibit segment-specific patterns of expression in mouse epididymis. Mol Reprod Dev 35:16-23.
47. Wu C (1980): The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I. Nature 286:854-859.
48. Xin JH, Cowie A, Lachance P, Hassel JA (1992): Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells. Genes Dev 6:481-496.
49. Yoshimura S, Watanabe K, Suemizu H, Onozawa T, Mizoguchi J, Tsuda K, Hatta H, Moriuchi T (1991): Tissue-specific expression of the plasma glutathione peroxidase gene in rat kidney. J Biochem 109:918-923.
50. Yoshimura S, Suemizu H, Taniguchi Y, Arimori K, Kawabe N, Moriuchi T (1994): The human plasma glutathione peroxidase-encoding gene: Organization, sequence and localization to chromosome 5q32. Gene 145:293-297.
51. Zhang M, Maass N, Magit D, Sager R (1997): Transactivation through Ets and API transcription sites determines the expression of the tumor-suppressing gene maspin. Cell Growth Different 8:179-186.