Cytokine release and its modulation by dexamethasone in whole blood following exercise

Clinical and Experimental Immunology

Volumn 111, Issue 2, 1998, Pages 463-468

  Smits, H H ^a   Grunberg K ^a   Derijk, R H ^b   Sterk, P J ^a   Hiemstra, P S ^a,c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c Department of Pulmonology Building 1 ^*  (Netherlands)

Author keywords

Cytokines; Dexamethasone; Exercise; Glucocorticoids; Whole blood

Indexed keywords

CD2 ANTIGEN; CD28 ANTIGEN; CORTICOTROPIN; CYTOKINE; CYTOKINE ANTIBODY; DEXAMETHASONE SODIUM PHOSPHATE; GAMMA INTERFERON; GLUCOCORTICOID; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; EXERCISE; FEMALE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOMODULATION; INFLAMMATION; LEUKOCYTE; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0031951619     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00482.x     Document Type: Article

References (35)

1. Cohen JJ, Scheimer HN, Claman HN, Oronsky AL, eds Anti-inflammatory steroid action. Basic and clinical aspects. San Diego: Academic Press, 1989:111-31.
2. Schwiebert LA, Beck LA, Stellato C, Bickel CA, Bochner BS, Schleimer RP. Glucocorticostetoid inhibition of cytokine production: relevance to antiallergic actions. J Allergy Clin Immunol 1996; 97:143-52.
3. Abbinante-Nissen JM, Simpson LG, Leikauf GD. Corticosteroids increase secretory leukocyte protease inhibitor transcript levels in airway epithelial cells. Am J Physiol 1995; 12:L601-L606.
4. van Furth AM, Seijmonsbergen EM, Langermans JA, van der Meide PH, van Furth R. Effect of xanthine derivates and dexamethasone on Streptococcus pneumoniae-stimulated production of tumor-necrosis factor alpha, interleukin-1 beta (IL-1 beta), and IL-10 by human leukocytes. Clin Diagn Lab Immunol 1995; 2:689-92.
5. Cypcar D, Busse WW. Steroid-resistant asthma. J Allergy Clin Immunol 1993; 92:362-72.
6. Kirkham B, Corkill MM, Davison SC, Panayi GS. Response to glucocorticoid treatment in rheumatoid arthritis: in vitro cell-mediated immune assay predicts in vivo response. J Rheumatol 1991; 18:1130.
7. Corrigan CJ, Brown PH, Barnes NC et al. Glucocorticoid resistance in chronic asthma: glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro. Am Rev Res Dis 1991; 144:101-25.
8. Spahn JD, Landwehr LP, Nimmagadda S, Susrs W, Leung DYM, Szetter SJ. Effects of glucocorticoids on lymphocyte activation in patients with steroid-sensitive and steroid-resistant asthma. J Allergy Clin Immunol 1996; 98:1073-9.
9. Nijhuis E, Hinloopen B, Van Duijn C, Hofman A, Rozing J, Nagelkerken L. Decreased sensitivity to dexamethasone in lymphocytes from patients with Alzheimer's disease. Clin Immunol lmmunopathol 1994; 73:45-52.
10. Adcock IM, Lane SJ, Brown CR, Peters MJ, Lee TH, Barnes PJ. Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma. J Immunol 1995: 154:3500-5.
11. Rosewicz S, McDonald AR, Maddux BA, Goldfine ID, Miesfeld RL, Logsdon CD. Mechanism of glucocorticoid receptor down-regulation by glucocorticoids. J Biol Chem 1988; 263:2581-4.
12. Korn SH, Wouters EFM, Wesseling G, Arends J, Thunnissen BJM. In vitro and in vivo modulation of α- and β-glucocorticoidreceptor mRNA in human bronchial epithelium. Am J Resp Crit Care Med 1997; 155:1117-22.
13. DeRijk RH, Petrides J, Deuster P, Gold PW, Sternberg EM. Changes in corticosteroid sensitivity of peripheral blood lymphocytes after strenuous exercise in humans. J Clin Endo Metabol 1996; 81:228-35.
14. Sauer J, Polack E, Wikinski S, Holsboer F, Stalla GK, Arzt E. The glucocorticoid sensitivity of lymphocytes changes according to the activity of the hypothalamic-pituitary-adrenocortical system. Psychoneuroendocrinol 1995; 20:269-80.
15. Brown DH, Sheridan JF, Pearl D, Zwillig BS. Regulation of mycobacterial growth by the hypothalamus-pituitary-adrenal axis: differential responses of Mycobacterium bovis BCC-resistant and -susceptible mice. Infect Immun 1993; 61:4793-800.
16. Dunn AJ, Vickers SL. Neurochemical and neuroendocrine responses to Newcastle disease virus administration in mice. Brain Res 1994; 645:103-12.
17. Barnes P. Mechanisms of action of glucocorticoids in asthma. Am J Resp Crit Care Med 1996; 154:S21-S27.
18. Brattsand R, Linden M. Cytokine modulation by glucocorticoids: mechanisms and actions in cellular studies. Aliment Pharmaeol 1996; 10:81-90.
19. DeRijk R, Michelson D, Karp B et al. Exercise and circadian rhythm-induced variations in plasma cortisol differentially regulate interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNFα) productions in humans: high sensitivity of TNFα and resistance of IL-6. J Clin Endo Metabol 1997; 82:2182-91.
20. Ertel W, Kremer J, Kennedy J et al. Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 1995; 85:1341-7.
21. Kremer J, Jarrar D, Steckholzer U, Ertel W. Interleukin-1, -6 and tumor necrosis factor-α release is down-regulated in whole blood from septic patients. Acta Haematol 1996; 95:268-73.
22. Fischer JR, Schindel M, Stein N et al. Selective suppression of cytokine secretion in patients with small-cell lung cancer. Anal Oncol 1995; 6:921-6.
23. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 1990; 265:621-36.
24. Dinarello CA. Interleukin-1 and interleukin-1 antagonism. Blood 1991; 77:1627-52.
25. Van der Pouw-Kraan T, Van Kooten C, Rensink I, Aarden L. Interleukin (IL)-4 production by human T cells: differential regulation of IL-4 vs. IL-2 production. Eur J Immunol 1992; 22:1237-41.
26. 2 in immune suppression following injury. Ann Surg 1991; 214:253-63.
27. Gearing AJH, Beckett P, Christodoulou M et al. Processing of tumour necrosis factor-α precursor by metalloproteinases. Nature 1994; 370:555-7.
28. McGeehan GM, Becherer JD, Bast RC Jr et al. Regulation of tumour necrosis factor-α processing by metalloproteinase inhibitor. Nature 1994; 370:558-61.
29. Nijhuis EWP, Hinloopen B, Odding J, Nagelkerken L. Abrogation of the suppressive effects of dexamethasone by PKC activation or CD28 triggering. Cell Immunol 1994; 156:438-47.
30. Kaveluars A, Zijlstra J, Bakker JM et al. Increased dexamethasone sensitivity of neonatal leukocytes: different mechanisms of glucocorticoid inhibition of T cell proliferation in adult and neonatal cells. Eur J Immunol 1995; 25:1346-51.
31. Kam JC, Szefler SJ, Surs W, Sher ER, Leung DYM. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J Immunol 1993; 151:346-6.
32. Bamberger CM, Bamberger A, de Castro M, Chrousos GP. Glucocorticoid receptor β, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 1995; 95:2435-41.
33. Bamberger CM, Schulte HM. Chrousos GP. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endoc Rev 1996; 17:245-61.
34. Espersen GT, Elbaek A, Ernst E et al. Effect of physical exercise on cytokines and lymphocyte subpopulations in human peripheral blood. APMIS 1990; 98:395-400.
35. Field CJ, Gougeon R, Marliss EB. Circulating mononuclear cell numbers and function during intense exercise and recovery. J Appl Physiol 1991; 71:1089-97.