Evidence that P2X purinoceptors mediate the excitatory effects of αβmethylene-ADP in rat locus coeruleus neurones

Neuropharmacology

Volumn 37, Issue 7, 1998, Pages 875-885

  Sansum, A J ^a   Chessell, I P ^a   Hicks, G A ^a   Trezise, D J ^a,b   Humphrey, P P A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

meADP; meATP; ADP S; Extracellular recording; Locus coeruleus; P2 purinoceptors; Whole cell patch clamp recording

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE DERIVATIVE; BICUCULLINE; PURINE P2X RECEPTOR; SURAMIN; TETRODOTOXIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DORSAL ROOT; LOCUS CERULEUS; MALE; NERVE CONDUCTION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; VAGUS NERVE;

ADENOSINE DIPHOSPHATE; ANIMALS; ENZYME INHIBITORS; LOCUS COERULEUS; MALE; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; SPINAL NERVE ROOTS; THIONUCLEOTIDES; VAGUS NERVE;

EID: 0031948102     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00095-1     Document Type: Article

References (40)

1. Abbracchio, M.P., Burnstock, G., 1994. Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol. Ther. 64, 445-475.
2. Barnard, E.A., Simon, J., Webb, T.E., 1997. Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms. Mol. Neurobiol. 15 (2), 103-129.
3. Bertrand, G., Chapal, J., Puech, R., Loubatieres-Mariani, M.M., 1991. Adenosine-5′-O-(2-thiodiphosphate) is a potent agonist at P2 purinoceptors mediating insulin secretion from perfused rat pancreas. Br. J. Pharmacol. 102, 627-630.
4. Brown, C., Tanna, B., Boarder, M.R., 1995. PPADS: an antagonist at endothelial P2Y-purinoceptors but not P2U-purinoceptors. Br. J. Pharmacol. 116, 2413-2416.
5. Cascalheira, J.F., Sebastiao, A.M., 1992. Adenine nucleotide analogues, including gamma-phosphate-substituted analogues, are metabolised extracellularly in innervated frog sartorius muscle. Eur. J. Pharmacol. 222, 49-59.
6. Cederbaum, J.M., Aghajanian, G.J., 1977. Catecholamine receptors of locus coeruleus neurones: pharmacological characterisation. Eur. J. Pharmacol. 44, 375-378.
7. Chapal, J., Loubatieres-Mariani, M.-M., 1981. Effects of phosphate-modified adenine nucleotide analogues of insulin secretion from perfused rat pancreas. Br. J. Pharmacol. 73, 105-110.
8. Chen, C.C., Akopian, A.N., Silvilotti, L., Colquhoun, D., Burnstock, G., Wood, J.N., 1995. A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377, 428-431.
9. Cherubini, E., North, R.A., Williams, J.T., 1988. Synaptic potentials in rat locus coeruleus neurones. J. Physiol. 406, 431-442.
10. Chessell, I.P., Michel, A.D., Humphrey, P.P.A., 1997. Functional evidence for multiple purinoceptor subtypes in the rat medial vestibular nucleus. Neuroscience 77, 783-791.
11. Collo, G., North, R.A., Kawashima, E., Merlopich, E., Neidhart, S., Surprenant, A., Buell, G., 1996. Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci. 16, 2495-2507.
12. Dunn, P.M., Blakeley, A.G., 1988. Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens. Br. J. Pharmacol. 93, 243-245.
13. Edwards, F.A., Gibb, A.J., Colquhoun, D., 1992. ATP receptor-mediated synaptic currents in the central nervous system. Nature 359, 144-147.
14. Evans, R.J., Lewis, C., Buell, G., Valera, S., North, R.A., Surprenant, A., 1995. Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2X purinoceptors). Mol. Pharmacol. 48, 178-183.
15. Frew, R., Baer, H.-P., 1979. Adenosine-αβ -methylene diphosphate effects in intestinal smooth muscle: sites of action and possible prostaglandin involvement. J. Pharmacol. Exp. Ther. 211, 525-529.
16. Fröhlich, R., Boehm, S., Illes, P., 1996. Pharmacological characterization of P2 purinoceptor types in rat locus coeruleus neurons. Eur. J. Pharmacol. 315, 255-261.
17. Harden, T.K., Boyer, J.L., Nicholas, R.A., 1995. P2-purinergic receptors: subtype-associated signalling responses and structure. Annu. Rev. Pharmacol. Toxicol. 35, 541-579.
18. Harms, L., Finta, E.P., Tschopl, M., Illes, P., 1992. Depolarization of rat locus coeruleus neurons by adenosine 5′-triphosphate. Neuroscience 48, 941-952.
19. Humphrey, P.P.A., Buell, G., Kennedy, I., Khakh, B.S., Michel, A.D., Surprenant, A., Trezise, D.J., 1995. New insights on P2X purinoceptors. Naunyn Schmiedebergs Arch. Pharmacol. 351, 1-12.
20. Khakh, B.S., Humphrey, P.P.A., Henderson, G., 1997. ATP-gated cation channels (P2X purinoceptors) in trigeminal mesencephalic nucleus neurones of the rat. J. Physiol. 498, 709-715.
21. Lewis, C., Neidhart, S., Holy, C., North, R.A., Buell, G., Surprenant, A., 1995. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377, 432-435.
22. Michel, A.D., McGuire, C., Grahames, C.B.A., Humphrey, P.P.A., 1994. Differences between the high affinity [3H]αβmeATP binding sites in the rat vas deferens and rat brain. Br. J. Pharmacol. 112, 513P.
23. Murrin, R.J., Boarder, M.R., 1992. Neuronal 'nucleotide' receptor linked to phospholipase C and phospholipase D? Stimulation of PC12 cells by ATP analogues and UTP. Mol. Pharmacol. 41, 561-568.
24. Naito, Y., Lowenstein, J.M.,1985. 5′Nucleotdase from rat heart membranes. Biochem. J. 226, 645-651.
25. North, R.A., 1996. P2X purinoceptor plethora. Semin. Neurosci. 8, 187-194.
26. Paxinos, G., Watson, C.R.R., 1982. The Rat Brain in Stereotaxic Coordinates. Academic Press, London.
27. Regenold, J.T., Haas, H.L., Illes, P., 1990. Inhibitory adenosine A1 receptors on rat locus coeruleus neurons, an intracellular study. Naunyn Schmiedebergs Arch. Pharmacol. 341, 225-231.
28. Sansum, A.J., Chessell, I.P., Humphrey, P.P.A., 1997. Characterisation of purinoceptors mediating responses to ATP on rat dorsal roots. Br. J. Pharmacol. 120, 128P.
29. Sansum, A.J., Chessell, I.P., Humphrey, P.P.A., 1998. Characterisation of the purinoceptor subtype which mediates the responses to αβmeADP on rat locus coeruleus neurones. Br. J. Pharmacol. 123, 70P.
30. Satchell, D.G., McGuire, M.H., 1975. Inhibitory effects of adenine nucleotide analogs on the isolated guinea-pig taenia coli. J. Pharmacol. Exp. Ther. 195, 540-548.
31. Schefner, S.A., Chiu, T.H., 1986. Adenosine inhibits locus coeruleus neurons: an intracellular study in a rat brain slice preparation. Brain Res. 366, 364-368.
32. Shen, K.Z., North, R.A., 1993. Excitation of rat locus coeruleus neurons by adenosine 5′-triphosphate: ionic mechanism and receptor characterization. J. Neurosci. 13, 894-899.
33. Surprenant, A., Buell, G., North, R.A., 1995. P2X recepters bring new structure to ligand-gated ion channels. Trends Neursci. 18, 224-229.
34. Surprenant, A., Rassendren, F., Kawashima, E., North, R.A., Buell, G., 1996. The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 272, 735-738.
35. Trezise, D.J., Kennedy, I., Humphrey, P.P.A., 1993. Characterization of purinoceptors mediating depolarization of rat isolated vagus nerve. Br. J. Pharmacol. 110, 1055-1060.
36. Trezise, D.J., Black, M.D., Grahames, C.B.A., Humphrey, P.P.A., 1996. Novel pharmacological characteristics of P2 purinoceptors mediating increases in firing rate of rat locus coeruleus neurones in vitro. Br. J. Pharmacol. 117, 319P.
37. Tschopl, M., Harms, L., Norenberg, W., Illes, P., 1992. Excitatory effects of adenosine 5′-triphosphate on rat locus coeruleus neurones. Eur. J. Pharmacol. 213, 71-77.
38. Valera, S., Hussy, N., Evans, R.J., Adami, N., North, R.A., Surprenant, A., Buell, G., 1994. A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP. Nature 371, 516-519.
39. Vials, A.J., Burnstock, G., 1994. The effect of suramin on vasodilator responses to ATP and 2-methylthio-ATP in the Sprague-Dawley rat coronary vasculature. Eur. J. Pharmacol. 251, 299-302.
40. Wilkinson, G.F., Purkiss, J.R., Boarder, M.R., 1993. The regulation of aortic endothelial cells by purines and pyrimidines involves co-existing P2Y-purinoceptors and nucleotide receptors linked to phospholipase C. Br. J. Pharmacol. 108, 689-693.