The Ick protein tyrosine kinase is not involved in antibody-mediated CD4 (CDR3-loop) signal transduction that inhibits HIV-1 transcription

European Journal of Immunology

Volumn 28, Issue 5, 1998, Pages 1445-1457

  Coudronnière, Nolwenn ^a   Corbeil, Jacques ^b   Robert Hebmann, Véronique ^a   Mesnard, Jean Michel ^a   Devaux, Christian ^a  

^a Centre National de la Recherche Scientifique   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anti CD4 antibody; CD4 CXCR4 complex; HIV; Signal transduction; Tyrosine kinase

Indexed keywords

CD4 ANTIGEN; PROTEIN TYROSINE KINASE;

ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

ANTI-HIV AGENTS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CYTOPLASM; GTP-BINDING PROTEINS; HIV-1; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MUTAGENESIS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; VIRULENCE FACTORS, BORDETELLA; VIRUS REPLICATION;

EID: 0031946529     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199805)28:05<1445::AID-IMMU1445>3.0.CO;2-P     Document Type: Article

References (43)

1. Littman, D. R., The structure of the CD4 and CD4 genes. Annu. Rev. Immunol. 1987. 5: 561-584.
2. Hwang, J., Yan, Y., Garrett, T. P. J., Liu, J., Rodgers, D. W., Garlick, R. L., Tarr, G. E., Husain, Y., Reinherz, E. L. and Harrison, S. C., Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature 1990. 348: 411-418.
3. Wu, H., Kwong, P. D. and Hendrickson, W. A., Dimeric association and segmental variability in the structure of human CD4. Nature 1997. 387: 527-530.
4. Clayton, L. K., Sieh, M., Pious, D. A. and Reinherz, E. L., Identification of human CD4 residues affecting class II MHC-versus HIV-1 gp120 binding. Nature 1989. 339: 548-551.
5. Arthos, J., Deen, K. C., Chaikin, M. A., Fornwald, J. A., Sathe, G., Sattentau, Q. J., Clapham, P. R., Weiss, R. A., Mc Dougal, J. S., Pietropaolo, C., Axel, R., Truneh, A., Maddon, P. J. and Sweet, R. W., Identification of the residues in human CD4 critical for the binding of HIV. Cell 1989. 57: 469-481.
6. Anderson, P., Blue, M. L., Morimoto, C. and Schlossman, S. F., Cross-linking of T3 (CDS) with T4 (CD4) enhances the proliferation of resting T lymphocytes. J. Immunol. 1987. 139: 678-682.
7. Rudd, C. E., Trevillyan, J. M., Dasgupta, J. D., Wong, L. L. and Schlossman, S. R, The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase from human T lymphocytes. Proc. Natl. Acad. Sci. USA 1988. 85: 5190-5194.
8. lck. Cell 1988. 55: 301-308.
9. lck with the cytoplasmic domain of CD4 modulates HIV-1 expression. EMBO J. 1994. 13: 774-783.
10. Benkirane, M., Jeang, K.-T. and Devaux, C., The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T-cells. EMBO J. 1994. 13: 5559-5569.
11. Chirmule, N., Kalyanaraman, V. S. and Pawha, S., Signal transduced through the CD4 molecule on T lymphocytes activate NF-(greek small letter kappa)B. Biochem. Biophys. Res. Commun. 1994. 203: 498-505.
12. Merzouki, A., Patel, P., Cassol, S., Ennaji, M., Tailor, P., Turcotte, F. R., O'Shaughnessy, M. and Arella, M., HIV-1 gp120/gp160 expressing cells up-regulate HIV-1 LTR directed gene expression in a cell line transfected with HIV-1 LTR-reporter gene constructs. Cell. Mol. Biol. 1995. 41: 445-452.
13. Popik, W. and Pitha, P. M., Binding of human immunodeficiency virus type 1 to CD4 induces the association and tyrosine phosphorylation of lck and Raf-1 and increses the nuclear levels of AP-1 and NF-(greek small letter script kappa)B. Mol. Cell. Biol. 1996. 16: 6532-6541.
14. lck in human CD4 T lymphocytes. Eur. J. Immunol. 1992. 23: 600-607.
15. lck SH3 domain binds to Pl3-kinase but not Pl4-kinase. Mol. Cell. Biol. 1993. 13: 7708-7717.
16. Benkirane, M., Schmid-Antomarchi, H., Littman, D. R., Hirn, M., Rossi, B. and Devaux, C., The cytoplasmic tail of CD4 is required for inhibition of human immundeficiency virus type 1 replication by antibodies that bind the immunoglobulin CDR3-like region in domain 1 of CD4. J. Virol. 1996. 69: 6904-6910.
17. Schmid-Antomarchi, H., Benkirane, M., Breittmayer, V., Husson, H., Ticchioni, M., Devaux, C. and Rossi, B., HIV induces activation of phosphatidylinositol 4-kinase and mitogen-activated protein kinase by interacting with T cell CD4 surface molecules. Eur J. Immunol. 1996. 26: 717-720.
18. + T cells. J. Biol. Chem. 1995. 270: 19364-19369.
19. Briant, L., Coudronnière, N., Robert-Hebmann, V., Benkirane, M. and Devaux, C., The binding of HIV-1 virions or gp120-anti-gp120 immune complexes to HIV-1 infected quiescent peripheral blood mononuclear cell reveals latent infection. J. Immunol. 1996. 156: 3994-4004.
20. Corbeau, P., Benkirane, M., Weil, R., David, C., Emiliani, S., Olive, D., Mawas, C., Serre, A. and Devaux, C., Ig CDR3-like region of the CD4 molecule is involved in HIV-induced syncitia formation, but not viral entry. J. Immunol. 1993. 150: 290-301.
21. Benkirane, M., Corbeau, P., Housset, V. and Devaux, C., An antibody that binds the immunoglobulin CDR3-like region of the CD4 molecule inhibits provirus transcription in HIV-infected T cells. EMBO J. 1993. 12: 4909-4921.
22. Emiliani, S., Coudronnière, N., Delsert, C. and Devaux, C., Structural and functional properties of HIV-1GER TAR sequences. J. Biomed. Sci. 1996. 3: 31-40.
23. Benkirane, M., Hirn, M., Carrière, D. and Devaux, C., Functional epitope analysis of the human CD4 molecule: antibodies that inhibit human immunodeficiency virus type 1 gene expression bind to the immunoglobulin CDR3-like region of CD4. J. Virol. 1996. 69: 6898-6903.
24. Briant, L, Signoret, N., Gaubin, M., Robert-Hebmann, V., Zhang, X., Murali, R., Greene, M. I., Piatier-Tonneau, D. and Devaux, C., Transduction of activation signal that follows HIV-1 binding to CD4 and CD4 dimerization involves the immunoglobulin CDR3-like region in domain 1 of CD4. J. Biol. Chem. 1997. 272: 19441-19450.
25. Wright, D. D., Sefton, B. M. and Kamps, M. P., Oncogenic activation of the lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia. Mol. Cell. Biol. 1994. 14: 2429-2437.
26. lck. J. Exp. Med. 1996. 183: 39-48.
27. tax. J. Virol. 1997. 71: 1975-1983.
28. Davis, C. B., Dikic, I., Unutmaz, D., Hill, C. M., Arthos, J., Siani, M. A., Thompson, D. A., Schlessinger, J. and Littman, D. R., Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J. Exp. Med. 1997. 186: 1793-1798.
29. Dragic, T., Chareau, P., Clavel, F. and Alizon, M., Complementation of murine cells for human immunodeficiency virus envelope/CD4-mediated fusion in human/ murine heterokaryons. J. Virol. 1992. 66: 4794-4802.
30. Lemasson, I., Briant, L., Hague, B., Coudronnière, N., Heron, L., David, C., Rebouissou, C., Kindt, T. and Devaux, C., An antibody that binds domain 1 of CD4 inhibits replication of HIV-1, but not HTLV-I, in a CD4-positive/p56lck-negative HTLV-I-transformed cell line. J. Immunol. 1996. 156: 859-865.
31. + T lymphocytes. Eur. J. Immunol. 1997. 27: 397-404.
32. lck/CD3-T cell receptor interactions and inhibits CDS signaling. Eur. J. Immunol. 1995. 25: 1417-1425.
33. Péléraux, A., Peyron, J.-F. and Devaux, C., Inhibition of HIV-1 replication by a monoclonal antibody directed toward the complementarity determining region 3-like domain of CD4 in CD45 expressing and CD45-deficient cells. Virology 1998. 242: 233-237.
34. Dimitrov, D. S., How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity. Cell 1997. 91: 721-730.
35. + T lymphocytes to intact or heparinase-treated subendothelial extracellular matrix by diffusible or anchored RANTES and MIP-1 beta. J. Immunol. 1994. 153: 4899-4906.
36. FAK and ZAP-70 in human T cells. J. Exp. Med. 1996. 184: 873-882.
37. Jabado, N., Pallier, A., Le Deist, R, Bernard, F., Fisher, A. and Hivroz, C., CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation. J. Immunol. 1997. 158: 94-103.
38. Mesnard, J. M., Lemasson, I. and Devaux, C., Characterization of a novel protein interacting with CD4 in p56lck negative MT-2 cells. J. Allergy Clin. Immunol. 1997. 99: 3210.
39. Devaux, C., Boucraut, J., Poirier, G., Corbeau, P., Rey, F., Benkirane, M., Perarnau, B., Kourilsky, F. and Chermann, J.-C., Anti-β2-microglobulin monoclonal antibodies mediate a delay in HIV1 cytopathic effect on MT4 cells. Res. Immunol. 1990. 141: 357-372.
40. Bedinger, P., Moriarty, A., von Borstel II, R. C., Donovan, N. J., Steimer, K. S. and Littman, D. R., Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4. Nature 1988. 334: 162-165.
41. Corbeau, P., Devaux, C., Kourilsky, F. and Chermann, J.-C., An early postinfection signal mediated by monoclonal anti-β2 microglobulin antibody is responsible for delayed production of human immunodeficiency virus type 1 in peripheral blood mononuclear cells. J. Virol. 1990. 64: 1459-1464.
42. Briant, L., Benkirane, M., Girard, M., Hirn, M., Iosef, C. and Devaux, C., Inhibition of human immunodeficiency virus type 1 production in infected peripheral blood mononuclear cells by human leukocyte antigen Class I-specific antibodies: evidence for a novel antiviral mechanism. J. Virol. 1996. 70: 5213-5220.
43. Hivert, B., Bouhanna, S., Diochot, S., Camu, W., Dayanithi, G., Henderson, C. E. and Valmier, J., Embryonic rat motoneurons express a functional P-type voltage-dependent calcium channel. Int. J. Dev. Neuroscience 1995. 13: 429-436.