Self-reactive B cells in nonautoimmune and autoimmune mice

Immunologic Research

Volumn 17, Issue 1-2, 1998, Pages 49-61

  Erikson, Jan ^a   Mandik, Laura ^a   Bui, Anh ^a   Eaton, Ashlyn ^a   Noorchashm, Hooman ^a   Nguyen, Kim Anh T ^a   Roark, Jessica H ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

Anti DNA; Autoimmunity; B cell; SLE; Tolerance

Indexed keywords

CELL NUCLEUS ANTIGEN; DNA ANTIBODY; RIBONUCLEOPROTEIN ANTIBODY;

ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; DISEASE MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSGENIC MOUSE;

EID: 0031943446     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786430     Document Type: Article

References (96)

1. Metcalf ES, Klinman NR: In vitro tolerance induction of neonatal murine B-cells. J Exp Med 1976; 143:1327-1340.
2. Metcalf ES, Klinman NR: In vitro tolerance induction of bone marrow cells: a marker for B-cell maturation. J Immunol 1977;118:2111-2116.
3. Pike BL, Abrams J, Nossal, GJV: Clonal anergy: inhibition of antigen-driven proliferation among single B lymphocytes from tolerant animals, and partial breakage of anergy by mitogens. Eur J Immunol 1983;13:214-220.
4. Sidman CL, Unanue ER: Receptor-mediated inactivation of early B lymphocytes. Nature 1975;257: 149-151.
5. Nemazee D, Buerki K: Clonal deletion of autoreactive B lymphocytes in hone marrow chimeras. Proc Natl Acad Sci USA 1990; 86:8039-8043.
6. Goodnow CC, Crosbie J, Adelstein S, Lavoie TB, Smith-Gill SJ, Brink RA, et al.: Altered immumiglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 1988;334: 676-682.
7. Hartley SB, Crosbie J, Brink R, Kantor AB, Basten A, Goodnow CC: Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 1991;353:765-769.
8. Erikson J, Radic MZ, Camper SA, Hardy RR, Carmack C, Weigert M: Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 1991;349: 331-334.
9. Tan EM, Chan EKL, Sullivan KF, Rubin RL: Antinuclear antibodies (ANAs): Diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity. Clin Immunol Immunopathol 1988;47:121-141.
10. Theofilopoulos AN, Dixon FJ: Murine models of systemic lupus erythematosus. Adv Immunol 1985; 37:269-390.
11. Izui S, Kelley VE, Masuda K, Yoshida H, Roths JB, Murphy ED: Induction of various autoantibodies by mutant gene lpr in several strains of mice. J Immunol 1984;133:227-233.
12. Madaio MP, Carlson J, Cataldo J, Ucci A, Migliorini P, Pankewycz O: Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits. J Immunol 1987;138: 2883-2889.
13. Ohnishi K, Ebling FM, Mitchell B, Singh RR, Hahn BH, Tsao BP: Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics. Int Immunol 1994;6:817-830.
14. Madaio MP, Hodder S, Schwartz RS, Stollar BD: Responsiveness of autoimmune and normal mice to nucleic acid antigens. J Immunol 1984;132:872-876.
15. Radic MZ, Weigert M: Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu Rev Immunol 1994;12:487-520.
16. Radic MZ, Mascelli MA, Erikson J, Shan H, Weigert M: Ig H and L chain contributions to autoimmune specificites. J Immunol 1991;146: 176-182.
17. Roark JH, Kuntz CL, Nguyen K-A, Caton AJ, Erikson J: Breakdown of B-cell tolerance in a mouse model of SLE. J Exp Med 1995;181:1157-1167.
18. Ibrahim SM, Weigert M, Basu C, Erikson J, Radic MZ: Light chain contribution to specificity in anti-DNA antibodies. J Immunol 1995; 155:3223-3233.
19. Cyster JG, Hartley SB, Goodnow CC: Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 1994;371:389-395.
20. Cyster JG, Goodnow CC: Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B-cell fate. Immunity 1995;3:691-701.
21. Nguyen KAT, Mandik L, Bui A, Kavaler J, Norvell A, Monroe JG, et al.: Characterization of anti-ssDNA B-cells in a non-autoimmune background. J Immunol, in press.
22. Fulcher DA, Basten A: Reduced life span of anergic self-reactive B-cells in a double-transgenic model. J Exp Med 1994;179:125-134.
23. Cyster JG, Hartley SB, Goodnow CC: Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 1993;371:389-395.
24. Cyster JG, Goodnow CC: Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B-cell fate. Immunity 1995;3:691-701.
25. Gay D, Saunders T, Camper S, Weigert M: Receptor editing: An approach by autoreactive B-cells to escape tolerance. J Exp Med 1993;177:999-1008.
26. Radic MZ, Erikson J, Litwin S, Weigert M: B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med 1993;177:1165-1173.
27. Tiegs SL, Russell DM, Nemazee D: Receptor editing in self-reactive bone marrow B-cells. J Exp Med 1993;177:1009-1020.
28. Chen C, Nagy Z, Radic MZ, Hardy RR, Huszar D, Camper SA, et al.: The site and stage of anti-DNA B-cell deletion. Nature 1995;373: 252-255.
29. Iliev A, Spatz L, Ray S, Diamond B: Lack of allelic exclusion permits autoreactive B-cells to escape deletion. J Immunol 1994; 153:3551-3556.
30. Tsao BP, Chow A, Cheroutre H, Song YW, McGrath ME, Kroneberg M: B-cells are anergic in transgenic mice that express IgM anti-DNA antibodies. Eur J Immunol 1993;23:2332-2339.
31. Roark JH, Bui A, Nguyen KAT, Mandik L, Erikson J: Persistance of functionally compromised anti-dsDNA B-cells in the periphery of non-autoimmune mice. Int Immunol, in press.
32. 31a Mandik-Nayak L, Bui A, Noorchasm H, Eaton A, Erikson J: Regulation of anti-double-stranded B cells in non-autoimmune mice: localization to the T-B interface of the splenic follicle. J Exp Med 1997;186:1257-1267.
33. Fulcher DA, Basten A: Reduced life span of anergic self-reactive B-cells in adouble-transgenic model. J Exp Med 1994;179:125-134.
34. Chan EYT, MacLennan ICM: Only a small proportion of splenic B-cells in adults are short-lived virgin cells. Eur J Immunol 1993; 23:357-363.
35. Fulcher DA, Lyons AB, Korn SL, Cooke MC, Koleda C, Parish C, et al.: The fate of self-reactive B-cells depends primarily on the degree of antigen receptor engagement and availability of T cell help. J Exp Med 1996;183:2313-2328.
36. Cyster J: Signaling thresholds and interclonal competition in preimmune B-cell selection. Immunol Rev 1997;156:87-101.
37. Jacobson BA, Rothstein TL, Marshak-Rothstein A: Unique site of IgG2a and rheumatoid factor production in MRL/lpr mice. Immunol Rev 1997;156:103-110.
38. Jacobson BA, Panka DJ, Nguyen KAT, Erikson J, Abbas AK, Marshak-Rothstein A: Anatomy of autoantibody production: Dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice. Immunity 1995; 3:509-519.
39. Rathmell JC, Cooke MP, Ho WY, Grein J, Townsend SE, Davis MM, et al.: CD95 (Fas)-dependent elimination of self-reactive B-cells upon interaction with CD4+ T cells. Nature 1995;376:181-184.
40. Rothstein TL, Wang JKM, Panka DJ, Foote LC, Wang Z, Stanger B, et al.: Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B-cells. Nature 1995;374:163-165.
41. Hagman J, Lo D, Doglio LT, Hacked J, Rudin CM, Haasch D, et al.: Inhibition of immunoglobulin gene rearrangement by the expression of a 12 transgene. J Exp Med 1989;169:1911-1929.
42. Shinkai Y, Rathbun G, Lam KP, Oltz E, Stewart V, Mendelsohn M, et al.: Rag-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 1992;68:855-867.
43. Spanopoulou E, Roman CAJ, Corcoran LM, Schlissel MS, Silver DP, Nemazee D, et al.: Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev 1994;8:1030-1042.
44. Chen C, Radic MZ, Erikson J, Camper SA, Litwin S, Hardy RR, et al.: Deletion and editing of B-cells that express antibodies to DNA. J Immunol 1994;152:1970-1982.
45. Hang L, Theofilopoulos AN, Balderas RS, Francis SJ, Dixon FJ: The effect of thymectomy on lupus-prone mice. J Immunol 1984;132:1809-1813.
46. Jabs DA, Burek CL, Hu Q, Kuppers RC, Lee B, Pendergast RA: Anti-CD4 monoclonal antibody therapy suppresses autoimmune disease in MRL/Mp-lpr/lpr mice. Cell Immunol 1992;141:496-507.
47. Wofsy D, Ledbetter JA, Hendler PL, Seaman WE: Treatment of murine lupus with monoclonal anti-T cell antibody. J Immunol 1985;134:852-857.
48. Offen D, Spatz L, Escowitz H, Factor S, Diamond B: Induction of tolerance to an IgG autoantibody. Proc Natl Acad Sci USA 1992;89:8332-8336.
49. Eisenberg RA, Craven SY, Warren RW, Cohen PL: Stochastic control of anti-sm autoantibodies in MRL/Mp-pr/lpr mice. J Clin Invest 1987;80:691-697.
50. Hardin JA: The lupus autoantigens and the pathogenesis of systemic lupus erythematosus. Arthritis Rheum 1986;29:457-460.
51. Roark JH, Kuntz CL, Nguyen KAT, Mandik L, Cattermole M, Erikson J: B-cell selection and allelic exclusion of an anti-DNA immunoglobulin transgene in MRL-lpr/lpr mice. J Immunol 1995;154:4444-4455.
52. Diamond B, Katz JB, Paul E, Aranow C, Lustgarten D, Scharff MD: The role of somatic mutation in the pathogenic anti-DNA response. Annu Rev Immunol 1992;10:731-757.
53. Singer PA, Balderas RS, McEvilly RJ, Bobardt M. Theofilopoulos AN: Tolerance-related Vb clonal deletions in normal CD4-8-, TCRa/b+ and abnormal lpr and gld cell populations. J Exp Med 1989; 170:1869-1877.
54. Herron LR, Eisenberg RA, Roper E, Kakkanaiah VN, Cohen PL, Kotzin BL: Selection of the T cell receptor repertoire in lpr mice. J Immunol 1993;151:3450-3459.
55. Rubio CF, Kench J, Russell DM, Yawger R, Nemazee D: Analysis of central B-cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes. J Immunol 1996;157:65-71.
56. Rathmell JC, Goodnow CC: Effects of the Lpr mutation on elimination and inactivation of self-reactive B-cells. J Immunol 1994;153: 2831-2842.
57. Zhou T, Bluethmann H, Eldridge J, Brockhaus M, Berry K, Mountz JD: Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice. J Immunol 1991;147:466-474.
58. Gillette-Ferguson I, Sidman CL: A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice. Eur J Immunol 1994;24:1181-1181.
59. Singer GG, Abbas AK: The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1994; 1:365-371.
60. Mandik L, Nguyen KAT, Erikson J: Fas receptor expression on B-lineage cells. Eur J Immunol 1995;25:3148-3154.
61. Onel KB, Tucek-Szabo CL, Ashany D, Lacy E, Nikolic-Zugic J, Elkon KB: Expression and function of the murine CD95/FasR/APO-1 receptor in relation to B-cell ontogeny. Eur J Immunol 1995; 25:2940-2947.
62. Drappa J, Brot N, Elkon KB: The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain MRL lpr/lpr. Proc Natl Acad Sci USA 1993; 90:10,340-10,344.
63. Mariani SM, Matiba B, Armandola EA, Krammer PH: The Apo-1/Fas (CD95) receptor is expressed in homozygous MRL-lpr mice. Eur J Immunol 1994;24:3119-3123.
64. Kischkel FC, Hellbardt S, Pawlita M, Krammer PH, Peter ME: Cytotoxicity-dependant APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with receptor. EMBO J 1995;14:5579-5588.
65. Taupin J-L, Tian Q, Kedersha N, Robertson M, Anderson P: The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death. Proc Natl Acad Sci USA 1995;92:1629-1633.
66. Gulbins E, Bissonnette R, Mahboubi A, Martin S, Nishioka W, Brunner T, Baier G, et al.: FAS-induced apoptosis is mediated via a ceramide-initiated RAS signal pathway. Immunity 1995; 2:341-351.
67. Cifone MG, De Maria R, Roncaioli P, Rippo MR, Azuma M, Lanier LL, et al.: Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med 1993;177:1547-1552.
68. Su X, Zhou T, Wang Z, Yang P, Jope RS, Mountz JD: Defective expression of hemutopoietic cell protein tyrosine phosphate (HCP) in lymphoid cells blocks Fas-mediated apoptosis. Immunity 1995;2:353-362.
69. Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995;81:505-512.
70. Stanger BZ, Leder P, Lee T-H, Kim E, Seed B: RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 1995;81:513-523.
71. Tian Q, Taupin J-L, Elledge S, Robertson M, Anderson P: Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. J Exp Med 1995;182:865-874.
72. Rothstein TL, Wang JKM, Panka DJ, Foote LC, Wang Z, Stanger B, et al.: Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B-cells. Nature 1995;374:163-165.
73. Rathmell JC, Goodnow CC: Effects of the Lpr mutation on elimination and inactivation of self-reactive B-cells. J Immunol 1994;1153:2831-2842.
74. Chiou S-K, Tseng C-C, Rao L, White E: Functional complementation of the Adenovirus E1B 19-Kiladalton Protein with Bcl-2 in the inhibition of apoptosis in infected cells. J Virol 1995;68:87-97.
75. Itoh N, Tsujimoto Y, Nagata S: Effect of bcl-2 on Fas antigen-mediated cell death. J Immunol 1993;151:621-627.
76. Strasser A, Harris AW, Huang DCS, Krammer PH, Cory S: Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. The EMBO J 1995;14:6136-6147.
77. Lacronique V, Mignon, A, Fabre M, Viollet B, Rouquet N, Molina T, et al.: Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nature Medicine 1996;2:80-86.
78. Strasser A, Whittingham S, Vaux DL, Bath ML, Adams JM, Cory S, et al.: Enforced bcl-2 expression in B-lymphoid cells prolongs antibody response and elicits autoimmune disease. Proc Natl Acad Sci USA 1991;88:8661-8665.
79. McDonnell TJ, Deane N, Platt FM, Nunez G, Jeager U, McKearn JP, et al.: Bcl-2-immunoglobin trangenic mice demonsrtate extended B-cell survival adn follicular lymphoproliferation. Cell 1989; 57:79-88.
80. Cory S: Regulation of lymphocyte survival by the Bcl-2 gene family. Annu Rev Immunol 1995; 13:513-543.
81. Katsumata M, Seigel R, Louie D, Miyashita T, Tsujimoto Y, Nowell P, et al.: Differential effects of Bcl-2 on T and B-cells in trangenic mice. Proc Natl Acad Sci USA 1992;89:11376-11380.
82. Hartley SB, Cooke MP, Fulcher DA, Harris AW, Cory S, Basten A, et al.: Elimination of self-reactive B-lymphocytes proceeds in two stages: arrested development and cell death. Cell 1993;72:325-335.
83. Nisitani S, Tsubata T, Murakami M, Okamato M, Honjo T: The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphey but not in the bone marrow. J Exp Med 1993;178: 247-1254.
84. Mandik L, Katsumata M, Erikson J: Effects of altered Bcl-2 expression on B lymphocyte expression. Annl NY Acad Sci 1997;815:40-54.
85. Kavaler J, Caton AJ, Staudt LM, Schwartz D, Gerhard W: A set of closely related antibodies dominates the primary antibody response to the antigenic site CB of the A/PR/8/34 influenza virus hemagglutinin. J Immunol 1990; 145:2312-2321.
86. Clarke SH, Huppi K, Ruezinsky D, Staudt L, Gerhard W, Weigert M: Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. J Exp Med 1985;161:687-704.
87. Stark S, Caton AJ: Antibodies that are specific for a single amino acid interchange in a protein epitope use structurally distinct variable regions. J Exp Med 1991;174:613-624.
88. Caton A, Swartzentruber J, Kuhl A, Carding S, Stark S: Activation and negative selection of functionally distinct subsets of antibody-secreting cells by influenza hemagglutinin as a viral and a neo-self antigen. J Exp Med 1996;183:13-26.
89. Cerosoli DM, Riley MP, Shih FF, Caton AJ: Genetic basis for T cell recognition of a major histocompatibility complex class II-restricted neo-self peptide. J Exp Med 1995;182:1327-1336.
90. Shlomchik M, Mascelli M, Shan H, Radic MZ, Pisetsky D, Marshak-Rothstein A, et al.: Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med 1990; 171:265-292.
91. Marion TN, Bothwell ALM, Briles DE, Janeway CA Jr: IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection. J Immunol 1989;142:4269-4274.
92. Mohan C, Adams S, Stanik V, Datta SK: Nucleosome: A major immunogen for pathagenic autoantibody-inducing T cells of lupus. J Exp Med 1993;177:1367-1381.
93. Lefeber WP, Norris DA, Ryan SR, Huff JC, Lee LA, Kubo M, et al.: Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J Clin Invest 1984;74: 1545-1551.
94. Golan TD, Elkon KB, Gharavi AE, Krueger JG: Enhanced membrane binding of autoantibodies to cultured keratinocy tes of SLE patients after UVB/UVA irradation. J Clin Invest 1992;90:1067-1076.
95. Casciola-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted in systematic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179:1317-1330.
96. Rumore PM, Steinman CR: Endogenous circulating DNA in systematic lupus erythematosus. occurance as mutlimeric complexes bound to histone. J Clin Invest 1990;86:69-74.