The effect of clinical outcome on platelet G proteins of major depressed patients

European Neuropsychopharmacology

Volumn 8, Issue 2, 1998, Pages 89-94

  Karege, Félicien ^a   Bovier, Philippe ^a   Stepanian, Renata ^a   Malafosse, Alain ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Antidepressant; Clinical outcome; Depression; Platelet G proteins

Indexed keywords

ANTIDEPRESSANT AGENT; CLOMIPRAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN; IMIPRAMINE; MAPROTILINE; PAROXETINE; PROTEIN SUBUNIT;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; THROMBOCYTE; TREATMENT OUTCOME;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BLOOD PLATELETS; BLOTTING, WESTERN; CLOMIPRAMINE; DEPRESSIVE DISORDER; FEMALE; GTP-BINDING PROTEINS; HUMANS; IMIPRAMINE; MALE; MIDDLE AGED; PAROXETINE; PSYCHIATRIC STATUS RATING SCALES; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 0031942984     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(97)00047-3     Document Type: Article

References (25)

1. Avissar S., Schreiber G. The involvement of guanine nucleotide binding proteins in the pathogenesis and treatment of affective disorders. Biol. Psychiatry. 31:1992;435-459.
2. Bech, P., 1988. A review of the antidepressant properties of serotonin reuptake inhibitors, in: Gastpar, M., Wakelin J.S. (Eds.), Adv. Biol. Psychiatry 17: Selective 5-HT Reuptake Inhibitors: Novel or Commonplace Agents. Karger, Basel, pp. 58-69.
3. Birnbaumer L., Abramowitz J., Brown A.M. Receptor-effector coupling by G proteins. Biochim. Biophys. Acta. 1031:1990;163-224.
4. Bobon, D.P., 1981. Le Système AMDP. Manuel de Documentation et de Quantification de la Psychopathologie, 2nd ed. Mardaga, Brussels.
5. Bourin M., Baker G.B. Do G proteins have a role in antidepressant actions? Eur. Neuropsychopharmacol. 6:1996;49-53.
6. Colin S.F., Chang H.-C., Mollner S.et al. Chronic lithium regulates the expression of adenylate cyclase and Giα in rat cerebral cortex. Proc. Natl. Acad. Sci. USA. 88:1991;10634-10637.
7. Costa e Salva J.A., Ruschel S.I., Caetano D., Rocha F.L., da Salva Lippi J.R., Arruda S., Azun M. Placebo-controlled study of Tianeptine in major depressive episodes. Neuropsychobiology. 35:1997;24-29.
8. Gilman A.G. G proteins: Transduction of receptor-generated signals. Ann. Rev. Biochem. 56:1987;615-649.
9. Hudson C.J., Young L.T., Li P.P., Warsh J.J. CNS transmembrane signal transduction abnormalities in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia. Synapse. 13:1993;278-293.
10. Karege F., Bovier P., Stepanian R., Gaillard J.-M. Change in platelet GTP-binding Protein in drug-free depressed patients. Hum. Psychopharmacol. 11:1996;115-121.
11. Lachman H.M., Papolos D.F. Abnormal signal transduction: a hypothetical model for bipolar affective disorder. Life Sci. 45:1989;1413-1426.
12. Lesch K.-P., Manji H.K. Signal transducing G proteins and antidepressant drugs. Evidence for modulation of a subunit gene expression in rat brain. Biol. Psychiatry. 32:1992;549-579.
13. Li P.P., Sibony D., Green M.A., Warsh J.J. Lithium modulation of phosphoinoside signaling system in rat cortex: selective effect on phorbol ester binding. J. Neurochem. 61:1993;1722-1730.
14. Manji H.K. G Proteins: Implications for psychiatry. Am. J. Psychiatry. 149:1992;746-759.
15. Manji H.K., Chen G., Shimon H., Hsiao J.K.et al. Guanine nucleotide-binding proteins in bipolar disorder. Effects of long-term treatment. Arch. Gen. Psychiatry. 52:1995;135-144.
16. Milligan G. Endocrine disorders associated with mutations in guanine nucleotide binding proteins. Baillière's Clin. Endocrinol. Metab. 10:1996;177-187.
17. Mooney J.J., Schatzberg A.F., Cole J.O., Kizuka P.P., Salomon M., Lerbinger J., Pappalardo K.M., Gerson B., Schildkraut J.J. Rapid antidepressant response to alprazolam in depressed patients with high catecholamine output and heterologous desensitization of platelt adenylate cyclase. Biol. Psychiatry. 23:1988;543-559.
18. Ozawa H., Rasenick M.M. Chronic electroconvulsive treatment augments coupling of the GTP-binding protein Gs to the catalytic moiety of adenylyl cyclase in a manner similar to that seen with chronic antidepressant drugs. J. Neurochem. 56:1991;330-338.
19. Ozawa H., Gsell W., Frolich L., Zochling R.et al. Imbalance of the Gs and Gi/o function in postmortem brain of depressed patients. J. Neural Transm. 94:1993;63-69.
20. Sachez-Blanque, A., 1989. In: A. Seva (Ed.), European Handbook of Psychiatry and Mental Health. University Press of Zaragoza, Anthropos, pp. 639-647.
21. Spiegel A.M. Heterotrimeric GTP-binding proteins: an expanding family of signal transducers. Med. Res. Rev. 12:1992;55-71.
22. Spiegel A.M., Weinstein L.S., Shenker A. Abnormalities in G proteins-coupled signal transduction pathways in human disease. J. Clin. Invest. 92:1993;1119-1125.
23. Wachtel H. Dysbalance of neuronal second messenger function in the aetiology of affective disorders: a pathophysiological concept hypothesising defects beyond first messenger receptors. J. Neural Transm. 75:1989;21-29.
24. Wilkie T.M., Gilbert D.J., Olsen A.S., Chen X.-N., Amatruda T.T.et al. Evolution of the mammalian G protein α subunit multigene family. Nat. Genet. 1:1992;85-91.
25. Young L.T., Li P.P., Kamble A.R., Siu K.P., Warsh J.J. Mononuclear leukocyte levels of G proteins in depressed patients with bipolar disorder or major depressive disorder. Am. J. Psychiatry. 151:1994;594-596.