L-arginine does not improve cortical perfusion or histopathological outcome in spontaneously hypertensive rats subjected to distal middle cerebral artery photothrombotic occlusion

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 4, 1996, Pages 612-622

  Prado, Ricardo ^a   Watson, Brant D ^a   Zhao, Weizhao ^a   Yao, Hiroshi ^a,b   Busto, Raul ^a   Dietrich, W Dalton ^a   Ginsberg, Myron D ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Cerebral blood flow; Cerebral ischemia; Endothelium derived relaxing factor; Nitric oxide synthase activation; Photothrombosis

Indexed keywords

ARGININE; IODOPHENAZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN PERFUSION; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STROKE; THROMBOSIS;

EID: 0029991603     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199607000-00011     Document Type: Article

References (28)

1. Ashwal S, Cole DJ, Osborne TN, Pearce WJ (1993) Low dose L-NAME reduces infarct volume in the rat MCAO/reperfusion model. J Neurosurg Anesthesiol 5:241-249
2. Back T, Zhao W, Ginsberg MD (1995) Three-dimensional image analysis of brain glucose metabolism/blood flow uncoupling and its electrophysiological correlates in the acute ischemic penumbra following middle cerebral artery occlusion. J Cereb Blood Flow Metab 15:566-577
3. Beckman JS (1991) The double-edged role of nitric oxide. J Dev Physiol 15:53-59
4. Buisson AI, Plotkine M, Boulu RG (1992) The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischemia. Br J Pharmacol 106:766-767
5. Buisson A, Margaill I, Callebert J, Plotkine M, Boulu RG (1993) Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia. J Neurochem 61:690-696
6. Choi DW (1993) Nitric oxide: friend or foe to the injured brain? Proc Natl Acad Sci USA 90:9741-9743
7. Dalkara T, Moskowitz MA (1994) The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia. Brain Pathol 4:49-57
8. Dalkara T, Morikawa E, Panahian N, Moskowitz MA (1994) Blood flow-dependent functional recovery in a rat model of focal cerebral ischemia. Am J Physiol 267:H678-H683
9. Dawson DA, Kusumoto K, Graham DI, McCulloch J, Macrae IM (1992) Inhibition of nitric oxide synthesis does not reduce infarct volume in a rat model of focal cerebral ischaemia. Neurosci Lett 142:151-154
10. Dietrich WD, Prado R, Watson BD (1988a) Photochemically stimulated blood-borne factors induce blood-brain barrier alterations. Stroke 19:857-862
11. Dietrich WD, Prado R, Watson BD, Nakayama H (19886) Middle cerebral artery thrombosis: acute blood-brain barrier consequences. J Exp Neuropathol Neurol 47:443-451
12. Dietrich WD, Nakayama H, Watson BD, Kanemitsu H (1989) Morphological consequences of early reperfusion following thrombotic or mechanical occlusion of the rat middle cerebral artery. Acta Neuropathol 78:605-614
13. Dietrich WD, Prado R, Watson BD, Busto R, Ginsberg MD (1991) Hemodynamic consequences of common carotid artery thrombosis and thrombogenically activated blood in rats. J Cereb Blood Flow Metab 11:957-965
14. Faraci FM, Brian JE Jr (1994) Nitric oxide and the cerebral circulation. Stroke 25:692-703
15. Forstermann U, Schmidt HHHW, Pollack JS, Sheng H, Mitchell JA, Warner TD, Nakane M, Murad F (1991) Isoforms of nitric oxide synthase. Biochem Pharmacol 42:1849-1857
16. Heistad DD, Mayhan WG, Coyle P, Baumbach GL (1990) Impaired dilation of cerebral arterioles in chronic hypertension. Blood Vessels 27:258-262
17. Hossmann K-A (1988) Pathophysiology of cerebral infarction. In: Handbook of Clinical Neurology (Vinken PJ, Bruyn GW, Klawans HL, eds), New York, Elsevier Science, pp 107-153
18. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265:1883-1885
19. ladecola C, Pelligrino DA, Moskowitz MA, Lassen NA (1994) Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab 14:175-192
20. Jacewicz M, Tanabe J, Pulsinelli WA (1992) The CBF threshold and dynamics for focal cerebral infarction in spontaneously hypertensive rats. J Cereb Blood Flow Metab 12:359-370
21. Kuluz J, Prado R, Dietrich WD, Schleien CL, Watson BD (1993) The effect of nitric oxide synthase inhibition on infarct vol-ume following reversible focal cerebral ischemia in conscious rats. Stroke 24:2023-2029
22. Markgraf CG, Kraydieh S, Prado R, Watson BD, Dietrich WD, Ginsberg MD (1993) Comparative histopathologic consequences of photothrombotic occlusion of the distal middle cerebral artery in Sprague-Dawley and Wistar rats. Stroke 24:286-293
23. Watson BD, Dietrich WD, Busto R, Wachtel MS, Ginsberg MD (1985) Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann Neurol 17:497-504
24. Watson BD, Dietrich WD, Prado R, Ginsberg MD (1987) Argon laser-induced arterial photothrombosis: characterization and possible application to therapy of arteriovenous malformations. J Neurosurg 66:748-754
25. Watson BD, Dietrich WD, Prado R, Nakayama H, Kanemitsu H, Futrell NN, Yao H, Markgraf CG, Wester P (1995) Concepts and Techniques of Experimental Stroke Induced by Cerebrovascular Photothrombosis. In Central Nervous System Trauma: Research Techniques (Ohnishi ST, Ohnishi T, eds), Boca Raton, CRC Press, pp 169-194
26. Wester P, Dietrich WD, Prado R, Watson BD, Globus MY-T, Leistra H (1992) Serotonin release into plasma following common carotid artery thrombosis. Stroke 23:870-875
27. Wester P, Watson BD, Prado R, Dietrich WD (1995) A photothrombotic "ring" model of rat stroke-in-evolution displaying putative penumbral inversion. Stroke 26:444-450
28. Yamamoto SE, Golanov SC, Berger SC, Reis DJ (1992) Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat. J Cereb Blood Flow Metab 12:717-726