An immunosuppressive regimen using FTY720 combined with cyclosporin in canine kidney transplantation

Transplant International

Volumn 11, Issue 2, 1998, Pages 95-101

  Suzuki, Seiichi ^a   Kakefuda, Toshihiro ^a   Amemiya, Hiroshi ^a   Chiba, Kenji ^b   Hoshino, Yukio ^b   Kawaguchi, Takafumi ^b   Kataoka, Hirotoshi ^b   Rahman, Fazlur ^b  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b Research Laboratories   (Japan)

Author keywords

Canine, kidney transplantation, FTY720; FTY720, kidney transplantation, canine; Kidney transplantation, canine, FTY720

Indexed keywords

CYCLOSPORIN; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFICACY; GRAFT SURVIVAL; GRANULOCYTE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CYCLOSPORINE; DOGS; DRUG EVALUATION, PRECLINICAL; DRUG THERAPY, COMBINATION; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; LEUKOCYTE COUNT; PROPYLENE GLYCOLS; SPHINGOSINE;

EID: 0031937980     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001470050111     Document Type: Article

References (20)

1. Amemiya H, Itoh H (1994) Mizoribine (Bredinin) mode of action and effect on graft rejection. In: Thomson AW, Starzl TE (eds) Immunosuppressive drugs: developments in anti-rejection therapy. Edward Arnold, London Boston Melbourne Auckland, pp 161-176
2. Amemiya H, Suzuki S, Niiya S, Watanabe H, Kotake T (1988) Synergistic effect of cyclosporine and mizoribine on survival of dog renal allografts. Transplantation 46: 768-771
3. Du Toit DF, Homan WP, Morris PJ (1981) The effect of cyclosporine on experimental renal and pancreatic allografts in the dog. In: White DJG (ed) Cyclosporin A: Proceedings of an International Conference on Cyclosporin A. Elsevier Biomedical, Amsterdam New York, Oxford, pp 101-120
4. Enosawa S, Suzuki S, Kakefda T, Li X-K, Amemiya H (1996) Induction of selective cell death targeting on mature T lymphocytes in rats by a novel immunosuppressant, FTY720. Immunopharmacology 34: 171-179
5. Ensley RD, Bristow MR, Olsen SL, Taylor DO, Hammond EH, O'Connell JB, Dunn D, Osburn L, Jones KW, Kauffman RS, Gay WA, Renlund DG (1993) The use of mycophenolate mofetil (RS-61443) in human heart transplant recipients. Transplantation 56: 75-82
6. Fujita T, Inoue K, Yamamoto S, Ikumoto S, Sasaki S, Toyama R, Chiba K, Hoshino Y, Okumoto T (1994) Fungal metabolites. Part II. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot (Tokyo) 47: 208-215
7. Homan WP, French ME, Millard P, Denton TG, Fabre JW, Morris PJ (1980) Studies on the effects of cyclosporin A upon renal allograft rejection in the dog. Surgery 88: 168-173
8. Ochiai T, Nakajima K, Nagata M, Hori S, Asano T, Isono K (1987) Studies of the induction and maintenance of long-term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats. Transplantation 44: 734-738
9. Papalois B, Wahoff D, Leone J, Aasheim T, Gilmore T, Sutherland DER (1996) The effect of a nonsteroid immunosuppressive regimen with RS-61443 and cyclosporine on kidney allograft survival in dogs. Transplant Proc 28: 937
10. Platz KP, Eckhoff DE, Hullett DA, Sollinger HW (1991) Prolongation of dog renal allograft survival by RS-61443, a new, potent immunosuppressive agent. Transplant Proc 23: 497-498
11. Platz KP, Eckhoff DE, Hullett DA, Sollinger HW (1991) RS-61443 studies: review and proposal. Transplant Proc 23: 33-35
12. RS-61443 Investigation Commitee - Japan (1995) Pilot study of mycophenolate mofetil (RS-61443) in the prevention of acute rejection following renal transplantation in Japanese patients. Transplant Proc 27: 1421-1424
13. Suzuki S (1993) Deoxyspergualin. Mode of action and clinical trials. Ann N Y Acad Sci 696: 263-269
14. Suzuki S, Mizuochi I, Amemiya H (1985) Immunological study of cyclosporine in heterotopic transplantation of canine hearts. Transplantation 39: 565-568
15. Suzuki S, Enosawa S, Kakefuda T, Amemiya H, Hoshino Y, Chiba K (1996) Long-term graft acceptance in allografted rats and dogs by treatment with novel immunosuppressant, FTY720. Transplant Proc 28: 1375-1376
16. Suzuki S, Enosawa S, Kakefuda T, Li X-K, Mitsusada M, Takahara S, Amemiya H (1996) Immunosuppressive effect of new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats. Transplant Immunol 4: 252-255
17. Suzuki S, Enosawa S, Kakefuda T, Shinomiya T, Amari M, Naoe S, Hoshino Y, Chiba K (1996) A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. Transplantation 61: 200-205
18. Suzuki S, Li X-K, Enosawa S, Shinomiya T (1996) A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes. Immunology 89: 518-523
19. Suzuki S, Li X-K, Shinomiya T, Enosawa S, Amemiya H, Amari M, Naoe S (1997) The induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720. Clin Exp Immunol 107: 103-111
20. White DJG, Nagao T, Davies HFS (1981) Experimental transplantation in small animals. In: White DJG (ed) Cyclosporin A: Proceedings of an International Conference on Cyclosporin A. Elsevier Biomedical, Amsterdam, New York, Oxford, pp 89-100