Normoglycemia restores β-cell replicative response to glucose in transplanted islets exposed to chronic hyperglycemia

Diabetes

Volumn 47, Issue 2, 1998, Pages 192-196

  Nacher, Victor ^a   Merino, Juan F ^a   Raurell, Mercè ^a   Soler, Joan ^a   Montanya, Eduard ^a  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIVISION; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL;

EID: 0031936955     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.47.2.192     Document Type: Article

References (38)

1. Yki-Jarvinen H: Glucose toxicity. Endocr Rev 13:415-431, 1992
2. Leahy JL, Bonner-Weir S, Weir GC: β-cell dysfunction induced by chronic hyperglycemia Diabetes Care 15:442-455, 1992
3. Bobertson RP, Olson LK, Zhang HJ: Differentiating glucose toxicity from glucose desensitization: a new message from the insulin gene. Diabetes 43:1085-1089, 1994
4. Olson LK, Redmon JB, Towle HC, Robertson RP: Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein. J Clin Invest 92:514-519, 1993
5. Poitout V, Olson LK, Robertson RP: Chronic exposure of βTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. J Clin Invest 97:1041-1046, 1996
6. Davalli AM, Pontiroli AE, Socci C, Bertuzzi F, Fattor B, Braghi S, di Carlo V, Pozza G: Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely: evidence supporting specific desensitization rather than β cell exhaustion. J Clin Endocr Metab 74:790-794, 1992
7. Hoenig M, MacGregor LC, Matchinsky FM: In vitro exhaustion of pancreatic β-cells. Am J Physiol 250:E502-E511, 1986
8. Kaiser N, Corcos Ap, Sarel I, Cerasi E: Monolayer culture of adult rat pancreatic islets on extracellular matrix: modulation of B-cell function by chronic exposure to high glucose. Endocrinology 129:2067-2076, 1991
9. Sako Y, Grill VE: Coupling of β-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats. Diabetes 39:1580-1583, 1990
10. Leahy JL, Bumhalo M, Chen C: β-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats. Diabetologia 36:1238-1244, 1993
11. Ling Z, Pipeleers DG: Prolonged exposure of human β-cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. J Clin Invest 98:2805-2812, 1996
12. Sweene I: Pancreatic β-cell growth and diabetes mellitus. Diabetologia 35:193-201, 1992
13. Sweene I: The role of glucose in the in vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic B-cells. Diabetes 31:754-760, 1982
14. Schuppin GT, Bonner-Weir S, Montana E, Kaiser N, Weir GC: Replication of adult pancreatic β-cells cultured on bovine corneal endothelial cell extracellular matrix. In Vitro Cell Dev Biol 29A:339-344, 1992
15. Andersson A, Korsgren O, Naeser P: DNA replication in transplanted and endogenous pancreatic islets of obese-hyperglycemic mice at different stages of the syndrome. Metabolism 38:974-978, 1988
16. Juang JH, Bonner-Weir S, Wu YJ, Weir GC: Beneficial influence of glycemic control upon the growth and function of transplanted islets. Diabetes 43:1334-1339, 1994
17. Korsgren O, Jansson L, Andersson A: Effects of hyperglycemia on function of isolated mouse pancreatic islets transplanted under kidney capsule. Diabetes 38:510-515, 1989
18. Korsgren O, Jansson L, Sandier S, Andersson A: Hyperglycemia-induced B-cell toxicity: the fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background. J Clin Invest 86:2161-2168, 1990
19. Jansson L, Eizirik DL, Pipeleers DG, Borg LA, Hellerstrom C, Andersson A: Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice. J Clin Invest 96:721-726, 1995
20. Ogawa Y, Noma Y, Davalli AM, Wu YJ, Thorens B, Bonner-Weir S, Weir GC: Loss of glucose-induced insulin secretion and GLUT-2 expression in transplanted β-cells. Diabetes 44:75-79, 1995
21. Montana E, Bonner-Weir S, Weir GC: β-cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice. J Clin Invest 91:780-787, 1993
22. Keymeulen B, Teng H, Vetri M, Gorus F, Pipeleers DG: Effect of donor islet mass on metabolic normalization in streptozotocin-diabetic rats. Diabetologia 35:719-724, 1992
23. Tobin BW, Lewis JT, Chen DZX, Fmegood DT: Insulin secretory function in relation to transplanted islet mass in STZ-induced diabetic rats. Diabetes 42:98-105, 1993
24. Warnock GL, Rajotte RV: Critical mass of purified islets that induce normoglycemia after implantation into dogs. Diabetes 37:467-470, 1988
25. Nacher V, Raurell M, Merino JF, Aranda O, Soler J, Montana E: β-cell growth and mass are preserved in long-term syngeneic islet transplantation in streptozocin-induced diabetic Lewis rats. Diabetes 45:1541-1546, 1996
26. Weibel ER: Point counting methods. In Stereological Methods. Vol 1. London, Academic, 1979, p. 101-161
27. Sweene I: Effects of aging on the regenerative capacity of the pancreatic B-cell of the rat. Diabetes 32:14-19, 1983
28. Bonner-Weir S, Deery D, Leahy JL, Weir GC: Compensatory growth of pancreatic B-cells in adult rats after short-term glucose infusion. Diabetes 38:49-53, 1989
29. Andersson A: On the factors that regulate growth of transplanted islets. J Autoimmun 3 (Suppl.):131-136, 1990
30. Mellgren A, Schnell Landstrom AH, Pettersson B, Andersson A: The renal subcapsular site offers better growth conditions for transplanted mouse pancreatic islet cells than the liver or spleen. Diabetologia 29:670-672, 1986
31. Sweene I, Andersson A: Effect of genetic background on the capacity for islet cell replication in mice. Diabetologia 27:464-467, 1984
32. Montana E, Bonner-Weir S, Weir GC: Transplanted β-cell response to increased metabolic demand: changes in β-cell replication and mass. J Clin Invest 93:1577-1582, 1994
33. Campisi J. Replicative senescence: an old lives' tale?: Cell 84:497-500, 1996
34. Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir GC: Vulnerability of islets in the immediate posttransplantation period: dynamic changes in structure and function. Diabetes 45:1161-1167, 1996
35. Ohzato H, Porter J, Monaco A, Montana E, Maki T: Minimum number of islets required to maintain euglycemia and their reduced immunogenicity after transplantation into diabetic mice. Transplantation 56:270-274, 1993
36. Merino JF, Nacher V, Raurell M, Aranda O, Soler E, Montanya E: Improved out-come of islet transplantation in insulin-treated diabetic mice: effects on β-cell mass and function. Diabetologia 40:1004-1010, 1997
37. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE: A second pathway for regeneration of adult exocrine and endocrine pancreas: a possible recapitulation of embryonic development. Diabetes 42:1715-1720, 1993
38. Bonner-Weir S, Trent DF, Zmachinski CJ, Clore ET, Weir GC: Limited B-cell regeneration in a B-cell deficient rat model: studies with dexamethasone. Metabolism 30:914-918, 1981