The structural basis of the biological actions of the GM-CSF receptor

CIBA Foundation Symposia

Volumn , Issue 204, 1997, Pages 19-32

  Nicola, Nicos A ^a   Smith, Alison ^a   Robb, Lorraine ^a   Metcalf, Donald ^a   Begley, C Glenn ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 3; INTERLEUKIN 3 RECEPTOR;

ANIMAL; CHEMISTRY; CYTOPLASM; DIMERIZATION; HUMAN; MOUSE; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CYTOPLASM; DIMERIZATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-3; MICE; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; RECEPTORS, INTERLEUKIN-3; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030637892     PISSN: 03005208     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Dranoff G, Crawford AD, Sadelain M et al 1994 Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science 264:713-716
2. Eder M, Ernst TJ, Ganser A et al 1994 A low affinity chimeric human α/β-granulocyte-macrophage colony-stimulating factor receptor induces ligand-dependent proliferation in a murine cell line. J Biol Chem 269:30173-30180
3. Golde DW, Ding DX, Rivas CI, Vera JC 1994 The colony-stimulating factors and molecular transport. Stem Cells (suppl) 12:61-66
4. Grant SM, Heel RC 1992 Recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF): a review of its pharmacological properties and prospective role in the management of myelosuppression. Drugs 43:516-560
5. Hilton DJ 1994 An introduction to cytokine receptors. In: Nicola NA (ed) Guidebook to cytokines and their receptors. Oxford University Press, Oxford, p 8-16
6. Ihle JN 1995 The Janus protein tyrosine kinase family and its role in cytokine signaling. Adv Immunol 60:1-35
7. Jenkins BJ, D'Andrea R, Gonda TJ 1995 Activating point mutations in the common β subunit of the human GM-CSF, IL-3 and IL-5 receptor suggest the involvement of β subunit dimerization and cell-type-specific molecules in signalling. EMBO J 14:4276-4287
8. Kinoshita T, Yokota T, Arai K-I, Miyajima A 1995 Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. EMBO J 14:266-275
9. Klingmüller U, Lorenz U, Cantley LC, Neel BG, Lodish HF 1995 Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80:729-738
10. Lopez AF, Vadas MA, Woodcock JM et al 1991 Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to all surface receptors on human eosinophils. J Biol Chem 266:24741-24747
11. Metcalf D, Nicola NA 1995 The hemopoietic colony-stimulating factors: from biology to clinical applications. Cambridge University Press, Cambridge
12. Miyajima A, Mui AL-F, Ogorochi T, Sakamaki K 1993 Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5. Blood 82:1960-1974
13. Mui AL-F, Wakao H, O'Farrell A-M, Harada N, Miyajima A 1995 Interleukin-3, granulocyte-macrophage colony-stimuladng factor and interleukin-5 transduce signals through two STAT5 homologues. EMBO J 14:1166-1175
14. Nicola NA (ed) 1994 Guidebook to cytokines and their receptors. Oxford University Press, Oxford
15. Nicola NA, Robb L, Metcalf D, Cary D, Drinkwater CC, Begley CG 1996 Functional inactivation in mice of the gene for the interleukin-3 (IL-3)-specific receptor β-chain: implications for IL-3 function and the mechanism of receptor transmodulation in hemopoietic cells. Blood 87:2665-2674
16. IL-3 receptor-deficient mice are normal. Immunity 2:211-222
17. Robb L, Drinkwater CC, Metcalf D et al 1995 Hematopoietic and lung abnormalities in mice with a null mutation of the common β subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. Proc Natl Acad Sci USA 92:9565-9569
18. Sakamaki K, Miyajima I, Kitamura T, Miyajima A 1992 Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J 11:3541-3549
19. Sato N, Sakamaki K, Terada N, Arai K, Miyajima A 1993 Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signalling. EMBO J 12:4181-4189
20. Stanley E, Lieschke GJ, Grail D et al 1994 Granulocyte-macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci USA 91:5592-5596
21. Takaki S, Murata Y, Kitamura T, Miyajima A, Tominaga A, Takatsu K 1993 Reconstitution of the functional receptors for murine and human interleukin-5. J Exp Med 177:1523-1529
22. Walker F, Nicola NA, Metcalf D, Burgess AW 1985 Hierarchical downmodulation of hemopoietic growth factor receptors. Cell 43:269-276
23. Yi T, Mui AL-F, Krystal G, IhIe JN 1993 Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor β-chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis. Mol Cell Biol 13:7577-7586