Lymph node human immunodeficiency virus RNA levels and resistance mutations in patients receiving high-dose saquinavir

Journal of Infectious Diseases

Volumn 177, Issue 2, 1998, Pages 477-480

  Schapiro, Jonathan M ^b   Winters, Mark A ^b   Vierra, Mark ^b   Crawford, Shannon ^b   Merigan, Thomas C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

SAQUINAVIR; VIRUS RNA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; LYMPH NODE; LYMPH NODE BIOPSY; PRIORITY JOURNAL; VIRUS GENE; VIRUS MUTANT; VIRUS TITRATION;

EID: 0031929731     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/517380     Document Type: Article

References (17)

1. Gulick R, Mellors J, Havlir D, et al. Potent and sustained antiretroviral activity of indinavir (IDV), zidovudine (ZDV), and lamivudine (3TC) [abstract Th B 931]. In: Program and abstracts: XI International Conference on AIDS (Vancouver, Canada). Vancouver: XI International Conference on AIDS Society, 1996.
2. Powderly WG, Sesion M, Conant M, Stein A, Clendeninn N. The efficacy of Viracept (nelfinavir mesylate, NFV) in pivotal phase I/II doubleblind randomized controlled trials as monotherapy and in combination with d4T or AZT/3TC [abstract 370]. In: Program and abstracts of the Fourth Conference on Retroviruses and Opportunistic Infections (Washington, DC). Washington DC: Infectious Diseases Society of America, 1997.
3. Carpenter CCJ, Fischl MA, Hammer SM, et al, for the International AIDS Society-USA. Antiretroviral therapy for HIV infection 1997, updated recommendations of an international panel. JAMA 1997;277:1962-9.
4. Conway B, Shillington A, Fransen S, Sninsky J, Kwok S, Montaner JSG. Use of ultra-sensitive PCR technology to provide insight into viral dynamics [abstract 96]. In: Programme and abstracts of the International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication (St. Petersburg, FL). St. Petersburg, FL: International Medical Press, 1997.
5. Pantaleo G, Graziosi C, Demarest JF, et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 1993;362:355-8.
6. Lafeuillade A, Poggi C, Profizi N, Tamalet C, Costes O. Human immunodeficiency virus type 1 kinetics in lymph nodes compared with plasma. J Infect Dis 1996;174:404-7.
7. Pantaleo G, Menzo S, Vaccarezza M, et al. Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N Engl J Med 1995;332:209-16.
8. + T-cell counts in HIV-infected patients. Ann Intern Med 1996;124:1039-50.
9. Winters MA, Tan LB, Katzenstein DA, Merigan TC. Biological variation and quality control of plasma human immunodeficiency virus type 1 RNA quantitation by reverse transcriptase polymerase chain reaction. J Clin Microbiol 1993;31:2960-6.
10. Haase AT, Henry K, Zupancic M, et al. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 1996;274:985-9.
11. Cohen OJ, Pantaleo G, Holodniy M, et al. Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes. J Infect Dis 1996;173:849-56.
12. Lafeuillade A, Tamalet C, Tourres C, et al. Lymphoid organs remain important sanctuaries of infections with HIV-1 during zidovudine-ddI combination therapy [abstract 298]. In: Program and abstracts of the Third Conference on Retroviruses and Opportunistic Infections (Washington, DC). Washington DC: Infectious Diseases Society of America, 1996.
13. Gunthard H, Wong J, Ignacio C, Havlir D, Richman D. Emergence of drug resistance in different tissue compartments in 10 patients using population-based sequencing after 1 year of potent antiretroviral therapy [abstract 66]. In: Programme and abstracts of the International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication (St. Petersburg, FL). St. Petersburg, FL: International Medical Press, 1997.
14. Cavert W, Notermans DW, Staskus K, et al. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science 1997;276:960-4.
15. Burgisser P, Spertini F, Weyrich-Suter C, Pagani JL, Meylan PRA. Monitoring responses to antiretroviral treatment in human immunodeficiency virus type 1-infected patients by serial lymph node aspiration. J Infect Dis 1997;175:1202-5.
16. Cohen OJ, Pantaleo G, Holodniy M, et al. Decreased human immunodeficiency virus type 1 plasma viremia during antiretroviral therapy reflects doxvnregulation of viral replication in lymphoid tissue. Proc Natl Acad Sci USA 1995;92:6017-21.
17. Markowitz M, Cao Y, Vesanen M, et al. Intensive virological assessment of aggressively treated subjects with recent and chronic HIV infection [abstract 126]. In: Programme and abstracts of the International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication (St. Petersburg, FL). St. Petersburg, FL: International Medical Press, 1997.