Selective impairment of serum antibody repertoires toward muscle and thymus antigens in patients with seronegative and seropositive myasthenia gravis

European Journal of Immunology

Volumn 28, Issue 8, 1998, Pages 2344-2354

  Sharshar, Tarek ^a,c   Lacroix Desmazes, Sebastien ^a   Mouthon, Luc ^a   Kaveri, Srini ^a   Gajdos, Philippe ^b   Kazatchkine, Michel D ^a  

^a INSERM   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c HÔPITAL BROUSSAIS   (France)

Author keywords

Antibody repertoire; Autoimmunity; Immunopathology; Myasthenia gravis; Seronegative myasthenia

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY;

ADULT; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; FEMALE; HUMAN; IMMUNOBLOTTING; MALE; MYASTHENIA GRAVIS; PRIORITY JOURNAL; SEROLOGY;

ADULT; AUTOANTIBODIES; AUTOIMMUNITY; CASE-CONTROL STUDIES; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MIDDLE AGED; MUSCLES; MYASTHENIA GRAVIS; ORGAN SPECIFICITY; RECEPTORS, CHOLINERGIC; THYMUS GLAND;

EID: 0031927266     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199808)28:08<2344::AID-IMMU2344>3.0.CO;2-T     Document Type: Article

References (34)

1. Vincent, A. and Newsom-Davis, J., Acetylcholine receptor antibody as a diagnosis test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays. J. Neurol. Neurosurg. Psychiatr. 1985. 48: 1246-1252.
2. Soliven, B. C., Lange, D. J., Penn, A. S., Younger, D., Jaretzki-III, A., Lovelace, R. E. and Rowland, L. P., Seronegative myasthenia gravis. Neurology 1988. 38: 514-517.
3. Lisak, R. and Barchi, R. (Eds.), Myasthenia gravis. Saunders. Philadelphia 1982, pp. 27-30, 112-113.
4. Lewis, R. A., Selwa, J. F. and Lisak, R. P., Myasthenia gravis: immunological mechanisms and immunotherapy. Ann. Neurol. 1995. 37: 51-62.
5. Downes, J. M., Greenwood, B. M. and Wray, S. H., Autoimmune aspects of myasthenia gravis. Q. J. Med. 1966. 35: 85-105.
6. Adner, M. M., Sherman, J. D., Ise, C., Schwab, R. S. and Dameshek, W., An immunologic survey of 48 patients with myasthenia Gravis. N. Engl. J. Med. 1964. 271: 1327-1333.
7. Christensen, P. B., Jensen, T. S., Tsiropoulos, I., Sorensen, T., Kjaer, M., Hojer-Pedersen, E., Rasmussen, M. J. and Lehfeldt, E., Associated autoimmune diseases in myasthenia gravis. A population-based study. Acta. Neurol. Scand. 1995. 91: 192-195.
8. Haury, M., Grandien, A., Sundblad, A., Coutinho, A. and Nobrega, A., Global analysis of antibody repertoires. 1. An immunoblot method for the quantitative screening of a large number of reactivities. Scand. J. Immunol. 1994. 39: 79-87.
9. Nobrega, A., Grandien, A., Haury, M., Hecker, L., Malanchère, E. and Coutinho, A., Functional diversity and clonal frequencies of reactivity in the available antibody repertoire. Eur. J. Immunol. 1998. 28: 1204-1215.
10. Penn, A., Schotland, D. and Lamme, S., Anti-muscle and anti-acetylcholine receptor receptor antibodies in myasthenia gravis. Muscle Nerve 1986. 9: 407-415.
11. Mouthon, L., Nobrega, A., Nicolas, N., Kaveri, S., Barreau, C., Coutinho, A. and Kazatchkine, M., Invariance and restriction towards a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults. Proc. Natl. Acad. Sci. USA 1995. 92: 3839-3843.
12. Mouthon, L., Haury, M., Lacroix-Desmazes, S., Barreau, C., Coutinho, A. and Kazatchkine, M. D., Analysis of the normal human IgG antibody repertoire. Evidence that IgG autoantibodies of healthy adults recognize a limited and conserved set of protein antigens in homologous tissues. J. Immunol. 1995. 154: 5769-5778.
13. Jobson, J. D. (Ed.), Applied multivariate data analysis: categorical and multivariate methods. Springer-Verlag, New York 1992, vol. II.
14. Nobrega, A., Haury, M., Grandien, A., Malanchère, E., Sunblad, A. and Coutinho, A., Global analysis of antibody repertoires. II. Evidence for specificity, self-selection and the immunological 'homunculus' of antibodies in normal serum. Eur. J. Immunol. 1993. 23: 2851-2859.
15. Lacroix-Desmazes, S., Mouthon, L., Coutinho, A. and Kazatchkine, M. D., Analysis of the natural human IgG antibody repertoire: life-long stability of reactivities towards self antigens contrasts with age-dependent diversification of reactivities against bacterial antigens. Eur. J. Immunol. 1995. 25: 2598-2604.
16. Mouthon, L., Lacroix-Desmazes, S., Nobrega, A., Barreau, C., Coutinho, A. and Kazatchkine, M. D., The self-reactive antibody repertoire of normal human serum IgM is acquired in early childhood and remains stable throughout life. Scand. J. Immunol. 1996. 44: 243-251.
17. Changeux, J.-P., Functional architecture and dynamics of the nicotinic acetylcholine receptor: an allosteric ligand-gated ion channel. In Changeux, J.-P., L. R., Purves, D. and Bloom, F. E. (Eds.) FIDIA research foundation neuroscience award lectures, Vol. 4. Raven Press, New York 1990, pp. 1988-1989.
18. Gautel, M., Lakey, A., Barlow, D. P., Holmes, Z., Scales, S., Leonard, K., Labeit, S., Mygland, A., Gilhus, N. E. and Aarli, J. A., Titin antibodies in myasthenia gravis: identification of a major immunogenic region of titin. Neurology 1993. 43: 1581-1585.
19. Kuks, J. B., Limburg, P. C., Horst, G. and Oosterhuis, H. J., Antibodies to skeletal muscle in myasthenia gravis. Part 2. Prevalence in nonthymoma patients. J. Neurol. Sci. 1993. 120: 78-81.
20. Mohan, S., Barohn, R. J., Jackson, C. E. and Krolick, K. A., Evaluation of myosin-reactivities antibodies from a panel of myasthenia gravis patients. Clin. Immunol. Immunopathol. 1994. 70: 266-273.
21. Drachman, D., Silva, S. D., Ramsay, D. and Pestronk, A., Humoral pathogenesis of myasthenia gravis. Ann. N. Y. Acad. Sci. 1987. 90-104.
22. Drachman, D. B., Myasthenia Gravis. N. Engl. J. Med. 1994. 330: 1797-1810.
23. Mosman, S., Vincent, A. and Newsom-Davis, J., Myasthenia gravis without acetylcholine receptor antibody: a distinct disease entity. Lancet 1986. 1: 116-118.
24. Pestronk, A., Drachman, D. and Self, S., Measurement of junctional acetylcholine receptors in myasthenia gravis: clinical correlates. Muscle Nerve 1985. 8: 245-251.
25. Brooks, E. B., Pachner, A. R., Drachman, D. B. and Kantor, F. S., A sensitive rosetting assay for detection of acetylcholine receptor antibodies using BC3H-1 cells: positive results in "antibody negative" myasthenia gravis. J. Neuroimmunol. 1990. 28: 83-93.
26. Yamamoto, T., Vincent, A., Ciulla, T. A., Lang, B., Johnston, I. and Newsome-Davis, J., Seronegative myasthenia gravis: a plasma factor inhibiting agonist-induced acetylcholine receptor function copurifies IgM. Ann. Neurol. 1991. 30: 550-557.
27. Kami, A., Zisman, A., Katz-Levy, Y., Paas-Rozner, M., Dayan, M., Brautbar, C., Abramsky, O., Sela, M. and Mozes, E., Reactivity of T cells from seronegative patients with myasthenia gravis to T cell epitopes of the human acetylcholine receptor. Neurology 1997. 19: 1638-1642.
28. Levinson, A. I. and Wheatley, L. M., The thymus and the pathogenesis of myasthenia gravis. Clin. Immunol. Immunopathol. 1996. 78: 1-5.
29. LeBrigand, H. P., Levasseur, P., Miranda, A. R., Gaud, C. and Wojarowski, I., Surgical treatment of myasthenia gravis by thymectomy: a report on 248 cases. Ann. Chir. 1980. 34: 169-175.
30. Buckingham, J., Howard, F. and Bernatz, P., The value of thymectomy in myasthenia gravis. Ann. Surg. 1976. 184: 453-458.
31. Milcox, N., Schluep, M., Ritter, M. A. and Newsom-Davis, J., The thymus in seronegative myasthenia gravis patients. J. Neurol. 1990. 238: 256-261.
32. Vincent, A., Hart, A., Barrett-Jolley, R., Yamamoto, T., Burges, J., Wray, D., Byrne, N., Molenaar, P. and Newsom-Davis, J., Seronegative myasthenia gravis. Evidence for plasma factor(s) interfering with acetylcholine receptor function. Ann. N. Y. Acad. Sci. 1993. 681: 529-538.
33. Schluep, M., Wilcox, N., Vincent, A., Dhoot, G. and Newsom-Davis, J., Acetylcholine receptor in human thymic myoid cells in situ: An immunological study. Ann. Neurol. 1987. 22: 212-215.
34. Scalding, G., Vincent, A. and Newsom-Davis, J., Acetylcholine receptor antibody synthesis by thymic lymphocytes: correlation with thymic histology. Neurology 1981. 31: 935-940.