Functional diversity and clonal frequencies of reactivity in the available antibody repertoire

European Journal of Immunology

Volumn 28, Issue 4, 1998, Pages 1204-1215

  Nobrega, Alberto ^a,b   Grandien, Alf ^a   Haury, Matthias ^a   Hecker, Laura ^b   Malanchère, Evelyne ^c   Coutinho, Antonio ^a  

^a INSTITUT PASTEUR   (France)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c NONE

Author keywords

Antibody repertoire; Diversity; Natural antibody

Indexed keywords

ANTIBODY; DODECYL SULFATE SODIUM; IMMUNOGLOBULIN M;

ANIMAL CELL; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY REACTION; ARTICLE; B LYMPHOCYTE; CROSS REACTION; IMMUNOBLOTTING; LIVER; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ANIMALS; ANTIBODY SPECIFICITY; B-LYMPHOCYTES; CELLS, CULTURED; CLONE CELLS; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN M; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; VARIATION (GENETICS);

EID: 0031981377     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199804)28:04<1204::AID-IMMU1204>3.0.CO;2-G     Document Type: Article

References (41)

1. Tonegawa, S., Somatic generation of antibody diversity. Nature 1983. 302: 575-581.
2. Freitas, A. A., Lembezat, M. P. and Coutinho, A., Expression of antibody V-regions is genetically and developmentally controlled and modulated by the B lymphocyte environment. Int. Immunol. 1989. 1: 342-354.
3. Pannetier, C., Even, J. and Kourilsky, P., T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol. Today 1995. 16: 176-181.
4. Davis, M. M. and Bjorkman, P., T-cell antigen receptor gene and T-cell recognition. Nature 1988. 334: 395-402.
5. Cohn, M. and Langman, R. E., The protecton: the unit of humoral immunity selected by evolution. Immunol. Rev. 1990. 115: 11-147.
6. Griffiths, A. D., Malmqvist, M., Marks, J. D., Bye, J. M., Embleton, M. J., McCafferty, J., Baier, M., Holliger, K. P., Gorick, B. D., Hughes-Jones, N. C., Hoogenboom, H. R. and Winter, G., Human anti-self antibodies with high specificity from phase display libraries. EMBO J. 1993. 12-2: 725-734.
7. Mennuni, C., Santini, C., Dotta, F., Farilla, L., Di Mario, U., Fierabracci, A., Bottazzo, G., Cortese, R. and Luzzago, A., Selection of phage-displayed peptides mimicking type 1 diabetes-specific epitopes. J. Autoimmun. 1996. 9: 431-436.
8. Nobrega, A., Haury, M., Grandien, A., Malanchère, E., Sundblad, A. and Coutinho, A., Global analysis of antibody repertoires. II. Evidence for specificity, self-selection and the Immunological "homunculus" of antibodies in normal serum. Eur. J. Immunol. 1993. 23: 2851-2859.
9. Mouthon, L., Nobrega, A., Nicolas, N., Kaveri, S. V., Barreau, C., Coutinho, A. and Kazatchkine, M. D., Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults. Proc. Natl. Acad. Sci. USA 1995. 92: 3839-3843.
10. Coutinho, A., Sundblad, A., Marcos, M. A. R., Haury, M. and Nobrega, A. (Eds.), Physiopathology of autoimmunity: the reactivities of natural antibodies define the boundaries of the immunological self in Progress in Immunology. Springer-Verlag, Budapest 1992.
11. Vyse, T. J. and Todd, J. A., Genetic Analysis of Autoimmune Disease. Cell 1996. 85: 311-318.
12. Andersson, J., Coutinho, A. and Melchers, F., Frequencies of mitogen-reactive B cells in the mouse. II. Frequencies of B cells producing antibodies which lyse sheep or horse erythrocytes, and trinitrophenylated or nitroiodophenylated sheep erythrocytes. J. Exp. Med. 1977. 145: 1520-1530.
13. Portnoï, D., Freitas, A., Bandeira, A., Holmberg, D. and Coutinho, A., Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice. J. Exp. Med. 1986. 164: 25-35.
14. Huetz, F., Sciard-Larsson, E.-L., Pereira, P., Portnoï, D. and Coutinho, A., T cell dependence of "natural" autoreactive B cell activation in the spleen of normal mice. Eur. J. Immunol. 1988. 18: 1615-1622.
15. Cumano, A., Dorshkind, K., Gillis, S. and Paige, C. J., The influence of S17 stromal cells and interleukin 7 on B cell development. Eur. J. Immunol. 1990. 20: 2183-2189.
16. Grandien, A., Modidgliani, Y., Coutinho, A. and Andersson, J., Suppression of B cell differentiation by ligation of membrane-bound IgM. Eur. J. Immunol. 1993. 23: 1561-1565.
17. Andersson, J., Coutinho, A., Lernhardt, W. and Melchers, F., Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte. Cell 1977. 10: 27-34.
18. Bernabé, R. R., Coutinho, A., Martinez-A, C. and Cazenave, P.-A., Immune networks. Frequencies of antibody-and idiotype-producing B cell clones in various steady states. J. Exp. Med. 1981. 154: 552-556.
19. Klinman, N. R. and Linton, P. J., The clonotype repertoire of B cell subpopulations. Adv. Immunol. 1988. 42: 1-93.
20. Köhler, G. and Shulman, M. J., Immunoglobulin M mutants. Eur. J. Immunol. 1980. 10: 467-476.
21. Hornick, C. L. and Karush, F., Antibody affinity - III. The role of multivalence. Immunochemistry 1972. 9: 325-340.
22. Möller, G., Immunoglobulin treatment: mechanisms of action. Immunol. Rev. 1994. 139: 6-188.
23. Coutinho, A., Kazatchkine, M. D. and Avrameas, S., Natural autoantibodies. Curr. Opin. Immunol. 1995. 7: 812-818.
24. Berneman, A., Ternynck, T. and Avrameas, S., Natural mouse IgG reacts with self antigens including molecules involved in the immune response. Eur. J. Immunol. 1992. 22: 625-633.
25. Haury, M., Grandien, A., Sundblad, A., Coutinho, A. and Nobrega, A., Global analysis of antibody repertoires. I. An immunoblot method for the quantitative screening of a large number of reactivities. Scand. J. Immunol. 1994. 39: 79-87.
26. Mouthon, L., Haury, M., Lacroix-Desmazes, S., Barreau, C., Coutinho, A. and Kazatchkine, M. D., Analysis of the normal human IgG antibody repertoire. Evidence that IgG autoantibodies of healthy adults recognize a limited and conserved set of protein antigens in homologous tissues. J. Immunol. 1995. 154: 5769-5778.
27. Coutinho, A., Freitas, A. A., Holmberg, D. and Grandien, A., Expression and selection of murine antibody repertoires. Int. Rev. Immunol. 1992. 8: 173-187.
28. Quintans, J. and Lefkovits, I., Precursor cells specific to sheep red blood cells in nude mice. Estimation of frequency in the microculture system. Eur. J. Immunol. 1973. 3: 392-398.
29. Ishigatsubo, Y., Steinberg, A. D. and Klinman, D. M., Autoantibody production is associated with polyclonal B cell activation in autoimmune mice. Eur. J. Immunol. 1988. 18: 1089-1093.
30. + B lymphocytes. Int. Immunol. 1990. 2: 515-520.
31. Grandien, A., Fucs, R., Nobrega, A., Andersson, J. and Coutinho, A., Negative selection of multireactive B cell clones in normal adult mice. Eur. J. Immunol. 1994. 24: 1345-1352.
32. Souroujon, M., White-Scharf, M. E., Andreschwartz, J., Gefter, M. L. and Schwartz, R. S., Preferential autoantibody reactivity of the preimmune B cell repertoire in normal mice. J. Immunol. 1988. 140: 4173-4179.
33. Shlomchik, M. J., Marshak-Rochstein, C. B., Wolfowicz, T. L., Rothstein, A. and Weigert, M. G., The role of clonal selection and somatic mutation in autoimmunity. Nature 1987. 328: 805-811.
34. Poncet, P., Huetz, F., Marcos, M. A. R. and Andrade, L., All VH11 genes expressed in peritoneal lymphocytes encode anti-bromelaine-treated mouse red blood cells autoantibodies but other VH gene families contribute to this specificity. Eur. J. Immunol. 1990. 20: 1583-1589.
35. Jerne, N. K., The natural selection theory of antibody formation. Proc. Natl. Acad. Sci. USA 1955. 41: 848-857.
36. Towbin, H. and Gordon, J., Immunoblotting and dot immunobinding. Current status and outlook. J. Immunol. Methods 1984. 72: 313-340.
37. O'Farrell, P. H., High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem. 1975. 250: 4007-4021.
38. Hirayama, A., Takagaki, Y. and Karush, F., Interaction of monoclonal anti-peptide antibodies with lysozyme. J. Immunol. 1985. 134: 3241-3247.
39. Briles, D. E., Forman, C., Hudak, S. and Claflin, J. L., The effects of idiotype on the ability of IgG1 anti-phosphorylcholine antibodies to protect mice from fatal infection with Streptococcus pneumoniae. Eur. J. Immunol. 1984. 14: 1027-1030.
40. Holmberg, D., Forsgren, S., Ivars, F. and Coutinho, A., Reactions among IgM antibodies derived from normal, neonatal mice. Eur. J. Immunol. 1984. 14: 435-441.
41. Sedgwick, J. D. and Holt, P. G., A solid phase immunoenzymatic technique for the enumeration of specific antibody secreting cells. J. Immunol. Methods 1983. 57: 301-309.