Cytokine responses in Trypanosoma cruzi-infected children in Paraguay

American Journal of Tropical Medicine and Hygiene

Volumn 58, Issue 1, 1998, Pages 119-121

  Samudio, Margarita ^a   Montenegro James, Sonia ^b   Cabral, Margarita ^a   Martinez, Jorge ^a   De Arias, Antonieta Rojas ^a   James, Mark A ^c  

^a Instituto de Investigaciones en Ciencias de la Salud Universidad Nacional de Asuncion   (Paraguay)

^b OCHSNER MEDICAL CENTER   (United States)

^c TULANE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; ENDEMIC DISEASE; HELPER CELL; HUMAN; PARAGUAY; PARASITEMIA; SERODIAGNOSIS; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

EID: 0031918405     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1998.58.119     Document Type: Article

References (15)

1. Tanowitz HB, Kirchhoff LV, Simon D, Morris SA, Weiss LM, Wittner M, 1992. Chagas' disease. Clin Microbiol Rev 5: 400-419.
2. Zhang L, Tarleton RL, 1996. Persistent production of inflammatory and anti-inflammatory cytokines and associated MHC and adhesion molecule expression at the site of infection and disease in experimental Trypanosoma cruzi infections. Exp Parasitol 84: 203-213.
3. Villinger F, Hunt D, Mayne A, Vuchetich M, Findley H, Ansari AA, 1993. Qualitative and quantitative studies of cytokines synthesized and secreted by non-human primate peripheral blood mononuclear cells. Cytokine 5: 459-479.
4. Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, Modlin RL, 1991. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254: 277-279.
5. Diaz-Mitroma F, Kumar A, Karimi S, Kryworucho M, Daftarian MR Creery WD, Filion LG, Cameron W, 1995. Expression of IL-10, IL-4 and IFN-gamma in unstimulated and mitogenstimulated peripheral blood lymphocytes from HIV-seropositive patients. Clin Exp Immunol 102: 31-39.
6. Dutra WO, Gollob KJ, Pinto-Dias JC, Gazzinelli G, Correa-Oliveira R, Coffman RL, Carvalho-Parra JF, 1997. Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection. Scand J Immunol 45: 74-80.
7. Silva JS, Twardzik DR, Reed SG, 1991. Regulation of T. cruzi infections in vitro and in vivo by transforming growth factor-β (TGF-β). J Exp Med 174: 539-545.
8. Silva JS, Morrisey PJ, Grabstein KH, Mohler KM, Anderson D, Reed SG, 1992. Interleukin 10 and IFN-gamma regulation of experimental T. cruzi infection. J Exp Med 175: 169-174.
9. Abrahamsohn IA, Coffman RL, 1996. Trypanosoma cruzi: IL-10, TNF, IFN-gamma, and IL-12 regulate innate and acquired immunity to infection. Exp Parasitol 94: 231-244.
10. Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, Kuhn R, Muller W, Trinchieri G, Sher A, 1996. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma, and TNF-alpha. J Immunol 157: 798-805.
11. Hunter CA, Ellis-Neyes LA, Slifer T, Kanaly S, Grunig G, Fort M, Rennick D, Araujo FG, 1997. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J Immunol 158: 3311-3316.
12. Silva JS, Vespa GNR, Cardoso MAG, Aliberti JCS, Cunha FQ, 1995. Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages. Infect Immun 63: 4862-4867.
13. Cardillo F, Voltarelli JC, Reed SG, Silva JS, 1996. Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells. Infect Immun 64: 128-134.
14. Hunter CA, Slifer T, Araujo F, 1996. Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon. Infect Immun 64: 2381-2386.
15. Zhang L, Tarleton 1996. Characterization of cytokine production in murine T. cruzi infection by in situ immunochemistry: lack of association between susceptibility and T helper type 2 cytokine production. Eur J Immunol 26: 102-109.