Proteolytic cleavage of retinoblastoma protein upon DNA damage and fasmediated apoptosis

Cell Biology and Toxicology

Volumn 14, Issue 2, 1998, Pages 133-140

  Diederich, L ^a   Fotedar, A ^b   Fotedar, R ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

Apoptosis; Caspases; Cell free apoptosis; DNA damage; DNA PK; Fas; Retinoblastoma

Indexed keywords

ANTIBODY; CYSTEINE PROTEINASE; DNA; FAS ANTIGEN; PROTEIN KINASE; PROTEINASE INHIBITOR; RETINOBLASTOMA PROTEIN;

APOPTOSIS; CONFERENCE PAPER; DNA DAMAGE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION;

ANTIBODIES; ANTIGENS, CD95; APOPTOSIS; BLOTTING, WESTERN; CASPASE 1; CASPASE 3; CASPASES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DNA DAMAGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME PRECURSORS; HUMANS; JURKAT CELLS; RETINOBLASTOMA PROTEIN; ULTRAVIOLET RAYS;

EID: 0031915575     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007434005573     Document Type: Conference Paper

References (30)

1. Almasan A, Yin Y, Kelly RE et al. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci USA. 1995;92:5436-40.
2. Alnemri ES, Livingston DJ, Nicholson DW et al. Human ICE/ CED-3 protease nomenclature. Cell. 1996;87:171.
3. An B, Dou QP. Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate. Cancer Res. 1996;56:438-42.
4. Brenot-Bosc F, Gupta S, Margolis RL, Fotedar R. Changes in the subcellular localization of replication initiation proteins and cell cycle proteins during G1 to S-phase transition in mammalian cells. Chromosoma. 1995; 103:517-27.
5. Carter T, Vancurova I, Sun I, Lou W, DeLeon S. A DNA-activated protein kinase from HeLa cell nuclei. Mol Cell Biol. 1990; 10:6460-71.
6. Casiano CA, Martin SJ, Green DR, Tan EM. Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis. J Exp Med. 1996; 184:765-70.
7. Chinnaiyan AM, Dixit VM. The cell-death machine. Curr Biol. 1996;6:555-62.
8. Dou QP, An B, Will PL. Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis. Proc Natl Acad Sci USA. 1995;92:9019-23.
9. Enari M, Hase A, Nagata S. Apoptosis by a cytosolic extract from Fas-activated cells. EMBO J. 1995;14:5201-8.
10. Enari M, Talanian RV, Wong WW, Nagata S. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature. 1996;380:723-6.
11. Fotedar R, Diederich L, Fotedar A. Apoptosis and cell cycle. In: Meijer L, Guidet S, Vogel L, eds. Progress in cell cycle research. New York: Plenum Press; 1996:147-63.
12. Haas-Kogan DA, Kogan SC, Levi D et al. Inhibition of apoptosis by the retinoblastoma gene product. EMBO J. 1995;14:461-72.
13. Han Z, Malik N, Carter T, Reeves WH, Wyche JT, Henrickson EA. DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. J Biol Chem. 1996;271:25035-40.
14. Jänicke RU, Walker PA, Lin XY, Porter AG. Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J. 1996; 15:6969-78.
15. Lazebnik YA, Kaufman SH, Desnoyers S, Poirier GG, Earnshaw WC. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 1994;371:346-7.
16. Lazebnik YA, Takahashi A, Moir RD et al. Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci USA. 1995;92:9042-6.
17. Le Romancer M, Cosulich SC, Jackson SP, Clarke PR. Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts. J Cell Sci. 1996;109:3121-7.
18. Martin SJ, Newmeyer DD, Mathias S et al. Cell-free reconstitution of fas-, UV radiation- and ceramide-induced apoptosis. EMBO J. 1995a;14:5191-200.
19. Martin SJ, O'Brien GA, Nishioka WK et al. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J Biol Chem. 1995b;270:6425-8.
20. Morgenbesser SD, Williams BO, Jacks T, DePinho RA. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature. 1994;371:72-4.
21. Nicholson DW, Thornberry NA. Caspases: killer proteases. TIBS. 1997;22:299-306.
22. Nicholson DW, Ali A, Thornberry NA et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995;376:37-43.
23. Oberhammer FA, Hochegger K, Froschl G, Tiefenbacher R, Pavelka M. Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J Cell Biol. 1994; 126:827-37.
24. Pan H, Griep AE. Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development. Genes Dev. 1995;9:2157-69.
25. Song Q, Lees-Miller SP, Kumar S et al. DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J. 1996; 15:3238-46.
26. Taya Y. RB kinases and RB-binding proteins: new points of view. Trends Biochem Sci. 1997;22:14-7.
27. Tewari M, Quan LT, O'Rourke K et al. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 1995;81:801-9.
28. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science. 1995;267:1456-62.
29. Thornberry NA, Bull HG, Calaycay JR et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature. 1992;356:768-74.
30. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell. 1995;81:323-30.