The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells

Immunology

Volumn 93, Issue 3, 1998, Pages 383-389

  Wever, P C ^a,b   Van Der Vliet, H J J ^b   Spaeny, L H A ^a   Wolbink, A M ^a   Van Diepen, F N J ^a   Froelich, C J ^c   Hack, C E ^a   Ten Berge, I J M ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c EVANSTON HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME B;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOSURVEILLANCE; LYMPHOCYTE CULTURE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; APOPTOSIS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FLOW CYTOMETRY; GRANZYMES; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; SERINE ENDOPEPTIDASES;

EID: 0031914631     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00448.x     Document Type: Article

References (37)

1. HENKART P.A. (1985) Mechansm of lymphocyte-mediated cytotoxicity. Annu Rev Immunol 3, 31.
2. LIU C.-C., WALSH C.M. & YOUNG J.D.-E. (1995) Perforin: structure and function. Immunol Today 16, 194.
3. FROELICH C.J., ORTH K., TURBOV J. et al. (1996) New paradigm for lymphocyte granule mediated cytotoxicily: targets bind and internalize granzyme B but an endosomolytic agent is necessary for cytosolic delivery and apoptosis. J Biol Chem 271, 29073.
4. EBNET K., HAUSMANN M., LEHMANN-GRUBE F. et al. (1995) Granzyme A-deficient mice retain potent cell-mediated cytotoxicity. EMBO J 14, 4230.
5. HEUSEL J.W., WESSELSCHMIDT R.L., SHRESTA S., RUSSEL J.H. & LEY T.J. (1994) Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76, 977.
6. CHINNAIYAN A.M. & DIXIT V.M. (1996) The cell-death machine. Curr Biol 6, 555.
7. ALNEMRI E.S., LIVINGSTON D.J., NICHOLSON D.W. et al. (1996) Human ICE/CED-3 protease nomenclature. Cell 87, 171.
8. SUNDER-PLASSMANN G., WAGNER L., HRUBY K., BALCKE P. & WORMAN C.P. (1990) Upregulation of a lymphoid serine protease in kidney allograft recipients. Kidney Int 37, 1350.
9. BERTHOU C., LEGROS-MAÏDA S., SOULIÉ A. et al. (1995) Cord blood T lymphocytes lack constitutive perform expression in contrast to adult peripheral blood T lymphocytes. Blood 85, 1540.
10. KUMMER J.A., KAMP A.M., TADEMA T.M., Vos W., MEIJER C.J.L.M. & HACK C.E. (1995) Localization and identification of granzymes A and B-expressing cells in normal lymphoid tissue and peripheral blood. Clin Exp Immunol 100, 164.
11. WEVER P.C., MULDER J.B.G., WEENING J.J. & TEN BERGE I.J.M. (1997) Immunocytochemical detection of granzymes A and B in peripheral blood lymphocytes from healthy individuals after non-enzymatic antigen retrieval. J Histochem Cytochem 45, 467.
12. Su B., BOCHAN M.R., HANNA W.L., FROELICH C.J. & BRAHMI Z. (1994) Human granzyme B is essential for DNA fragmentation of susceptible target cells. Eur J Immunol 24, 2073.
13. HACK C.E., PAARDEKOPER J., SMEENK R.J.T., ABBINK J.J., EERENBERG A.J.M. & NIJENS J.H. (1988) Disruption of the internal thioester bond in the third component of complement (C3) results in the exposure of neodeterminants also present on activation products of C3. An analysis with monoclonal antibodies. J Immunol 141, 1602.
14. HANNA W.L., ZHANG X., TURBOV J., WINKLER U., HUDIG D. & FROELICH C.J. (1993) Rapid purification of cationic granule proteases: application to human granzymes. Protein Expr Purif 4, 398.
15. SLAPER-CORTENBACH I.C.M., ADMIRAAL L.G., KERR J.M., VAN LEEUWEN E.F., VON DEM BORNE A.E.G.K. & TETTEROO P.A.T. (1988) Flow-cytometric detection of terminal deoxynucleotidyl transferase and other intracellular antigens in combination with membrane antigens in acute lymphatic leukemias. Blood 72, 1639.
16. KOOPMAN G., REUTELINGSPERGER C.P.M., KUIJTEN G.A.M., KEEHNEN R.M.J., PALS S.T. & VAN OERS M.H.J. (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84, 1415.
17. MARTIN S.J., REUTELINGSPERGER C.P.M., MCGAHON A.J., et al. (1995) Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 182, 1545.
18. LIU C-C., RAFII S., GRANELLI-PIPERNO A., TRAPANI J.A. & YOUNG J.D.-E. (1989) Perforin and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A. J Exp Med 170, 2105.
19. COHEN J.J. (1993) Apoptosis. Immunol Today 14, 126.
20. LEBOW L.T. & BONAVIDA B. (1990) Purification and characterization of cytolytic and non-cytolytic human natural killer cell subsets. Proc Natl Acad Sci USA 87, 6063.
21. TRAPANI J.A., KLEIN J.L., WHITE P.C. & DUPONT B. (1988) Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes. Proc Natl Acad Sci USA 85, 6924.
22. SALCEDO T.W., AZZONI L., WOLF S.F. & PERUSSIA B. (1993) Modulation of perforin and granzyme messenger RNA expression in human natural killer cells. J Immunol 151, 2511.
23. KOIZUMI H., LIU C-C., ZHENG L.M. et al. (1991) Expression of perforin and serine esterases by human γδ T cells. J Exp Med 173, 499.
24. AZUMA M., PHILLIPS J.H. & LANIER L.L. (1993) CD28 T lymphocytes. Antigenic and functional properties. J Immunol 150, 1147.
25. AZUMA M., CAYABYAB M., PHILLIPS J.H. & LANIER L.L. (1993) Requirements for CD28-dependent T cell-mediated cytotoxicity. J Immunol 150, 2091.
26. + counterparts. J Immunol 156, 3587.
27. TESTI R., D'AMBROSIO D., DE MARIA R. & SANTONI A. (1994) The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol Today 15, 479.
28. ROEDERER M., DUBS J.G., ANDERSON M.T., RAJU P.A., HERZENBERG L.A. & HERZENBERG L.A. (1995) CD8 naive T cell counts decrease progressively in HIV-infected adults. J Clin Invest 95, 2061.
29. AKBAR A.N., BORTHWICK N., SALMON M. et al. (1993) The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J Exp Med 178, 427.
30. AKBAR A.N. & SALMON M. (1997) Cellular environments and apoptosis: tissue microenvironments control activated T-cell death. Immunol Today 18, 72.
31. + T lymphocytes during HIV infection. J Immunol 156, 2282.
32. MASSAIA M., BORRIONE P., ATTISANO C. et al. (1995) Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients. Blood 85, 3679.
33. + T cells: sign of a possible role for herpes viruses as cofactors? Blood 86, 1400.
34. EMLEN W., NIEBUR J. & KADERA R. (1994) Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 152, 3685.
35. Ju S.-T., PANKA D.J., CUI H. et al. (1995) Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373, 444.
36. OWEN-SCHAUB L.B., YONEHARA S., CRUMP W. L. III & GRIMM E.A. (1992) DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cell Immunol 140, 197.
37. MIYAWAKI T., UEHARA T., NIBU R. et al. (1992) Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J Immunol 149, 3753.