Excessive production of nitric oxide by macrophages from DP-BB rats is secondary to the T-lymphopenic state of these animals

Diabetes

Volumn 47, Issue 2, 1998, Pages 197-205

  Lau, Albert ^a   Ramanathan, Sheela ^a   Poussier, Philippe ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; MACROPHAGE ACTIVATION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

EID: 0031914014     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.47.2.197     Document Type: Article

References (54)

1. Rossini AA, Mordes JP, Greiner DL: The pathogenesis of autoimmune diabetes mellitus. (Review). Curr Opin Immunol 2:598-603, 1990
2. Jackson R, Rassi N, Crump T, Haynes B, Eisenbarth GS: The BB diabetic rat: profound T-cell lymphocytopenia. Diabetes 30:887-889, 1981
3. Elder ME, Maclaren NK: Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat. J Immunol 130:1723-1731, 1983
4. Poussier P, Nakhooda AF, Falk JA, Lee C, Marliss E: Lymphopenia and abnormal lymphocytes subsets in the "BB" rat: relationship to the diabetic syndrome. Endocrinology 110:1825-1827, 1982
5. Bellgrau D, Naji A, Silvers WK, Markmann JF, Barker CF: Spontaneous diabetes in BB rats: evidence for a T cell dependent immune response defect. Diabetologia 23:359-364, 1982
6. Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark A, Lander ES: Genetic dissection of autoimmune type I diabetes in the BB rat. Nat Genet 2:56-60, 1992. (Erratum in Nat Genet 7:215, 1994.)
7. Zadeh HH, Greiner DL, Wu DY, Tausche F, Goldschneider I: Abnormalities in the export and fate of recent thymic emigrants in diabetes-prone BB/W rats. Autoimmunity 24:35-46, 1997
8. Woda BA, Like AA, Padden C, McFadden ML: Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat. J Immunol 136:856-859, 1986
9. Prud'homme GJ, Fuks A, Colle E, Seemayer TA, Guttmann RD: Immune dysfunction in diabetes-prone BB rats: Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages. J Exp Med 150:463-478, 1984
10. Dyrberg T, Lernmark A, Oie HK, Gazdar AF: Islet cell surface antibodies in spontaneously diabetic BB rats. Acta Biol Med Ger 41:1105-1109, 1982
11. Baekkeskov S, Dyrberg T, Lernmark Å: Autoantibodies to a 64-kilodalton islet cell protein precede the oaset of spontaneous diabetes in the BB rat. Science 224:1348-1550, 1984
12. Van Rees RE, Voorbij HA, Dijkstra CD: Neonatal development of lymphoid organs and specific immune responses in situ in diabetes-prone BB rats. Immunology 65:465-472, 1988
13. Lee KU: Nitric oxide produced by macrophages mediates suppression of ConA-induced proliferative responses of splenic leukocytes in the diabetesprone BB rat. Diabetes 43:1218-1220, 1994
14. Marcinkiewicz J, Chain BM: Differential regulation of cytokine production by nitric oxide. Immunology 80:146-150, 1993
15. Upham JW, Strickland DH, Bilyk N, Robinson BWS, Holt PG: Alveolar macrophages from humans and rodents selectively inhibit T cell proliferation but permit T-cell activation and cytokine secretion. Immunology 84:142-147, 1995
16. Colle E, Guttmann RD, Fuks A: Insulin-dependent diabetes mellitus is associated with genes that map to the right of the class I RT1.A locus of the major histocompatibility complex of the rat. Diabetes 35:454-458, 1986
17. Colle E, Fuks A, Poussier P, Edouard P, Guttman RD: Polygenic nature of spontaneous diabetes in the rat: permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility. Diabetes 41:1617-1623, 1992
18. Wu G, Flynn NE: The activation of the arginine-citrulline cycle in macrophages from the spontaneously diabetic BB rat. Biochem J 294:113-118, 1993
19. G-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat. Diabetes 44:360-364, 1995
20. Hanenberg H, Kolb BV, Kantwerk FG, Kolb H: Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats. Diabetologia 32:126-134, 1989
21. Kolb BV, Kolb H: A role for macrophages in the pathogenesis of type 1 diabetes (Review). Autoimmunity 3:145-154, 1989
22. Kolb BV, Schraermeyer U, Hoppe T, Hanenberg H, Kolb H: Diabetes manifestation in BB rats is preceded by pan-pancreatic presence of activated inflammatory macrophages. Pancreas 7:578-584, 1992
23. GMMA. FEBS Lett 299:103-106, 1992
24. Kroncke KD, Kolb BV, Berschick B, Burkart V, Kolb H: Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation. Biochem Biophys Res Commun 175:752-758, 1991
25. Poussier P, Teh HS, Julius M: Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I restricted transgenic T cell receptor α/β in the intestinal epithelium. J Exp Med 178:1947-1957, 1993
26. Nicolls MR, Aversa GA, Pearce NW, Spinilli A, Berger MF, Gurley KE, Hall BM: Induction of long term specific tolerance to allografts in vivo by therapy with a monoclonal antibody to rat CD3. Transplantation 55:459-468, 1993
27. Robinson AP, White TM, Mason DW: Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC-OX-41 and MRC-OX42, the latter recognizing complement receptor type 3. Immunology 57:239-247, 1986
28. Mason DW, Arthur MJ, Dallman MJ, Green JR, Spickett GP, Thomas ML: Functions of rat T lymphocyte subsets isolated by means of monoclonal antibodies. Immunol Rev 57:74-91, 1983
29. Hunig T, Wallny HJ, Harley JK, Lawetzky A, Tiefenthaler G: A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation: differential reactivity with subsets of immature and mature T lymphocytes. J Exp Med 169:173-178, 1989
30. Mojcik CF, Greiner DL, Goldschneider I, Lubaroff DM: Monoclonal antibodies to RT7 and LCA antigens in the rat: cell distribution and segregation analysis. Hybridoma 6:531-543, 1987
31. Chambers WH, Vujanovic NL, DeLeo AB, Olszowy MW, Herverman RB, Hiserodt JC: Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine activated killer cells. J Exp Med 169:1373-1389, 1989
32. Moncada S, Palmer M, Higgs E: Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 42:109-142, 1991
33. Ding AH, Nathan CE Stuehr DJ: Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages, comparison of activating cytokines and evidence for independent production. J Immunol 141:2407-2412, 1988
34. Lowenthal JW, Corthesy P, Tougne C, Lees R, Nabhol Z: High and low affinity IL-2 receptors: analysis of IL-2 dissociation rate and reactivity with monoclonal anti-receptor antibody PC61. J Immunol 135:3988-3994, 1985
35. + T-cells are required for adoptive transfer of the BB rat diabetic syndrome. Diabetes 42:390-397, 1993
36. Woda BA, Padden C: Mitogen responsiveness of lymphocytes from the BB/W rat. Diabetes 35:513-516, 1986
37. Bellgrau D, Redd JM, Sellins KS: Peculiar T-cell signaling does not preclude positive selection in the diabetes-prone BB rat. Diabetes 43:47-52, 1994
38. Mordes JP, Gallina DL, Handler ES, Greiner DL, Nakamura N, Pelletier A, Rossini AA Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat. Diabetologia 30:22-26, 1987
39. Angelillo M, Greiner DL, Mordes JP, Handler ES, Nakamura N, McKeever U, Rossini A Absence of RT6+ T cells in diabetes-prone biobreeding/Worcester rats is due to genetic and cell developmental defects. J Immunol 141:4146-4151, 1988
40. Deng W, Thiel B, Tannenbaum CS, Hamilton TA Stuehr DJ: Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages. J Immunol 151:322-329, 1993
41. Hosszufalusi N, Chan E, Granger G, Charles MA Quantitative analyses comparing all major spleen cell phenotypes in BB and normal rats: autoimmune imbalance and double negative T cells associated with resistant, prone and diabetic animals. J Autoimmunity 5:305-318, 1992
42. Zipris D, Greiner DL, Malkani S, Whalen B, Morder JP, Rossini AA Cytokine gene expression in islet and thyroids of BB rat. J Immunol 156:1315-1321, 1996
43. Fu Y, Blankenhorn EP: Nitric oxide-induced anti-mitogenic effects in high and low responder rat strains. J Immunol 148:2217-2222, 1992
44. Van der Meide PH, De Labie MCDC, Botman CAD, Aten J, Weening JJ: Nitric oxide suppresses IFN-γ production in the spleen of mercuric chloride-exposed Brown Norway rats. Cell Immunol 161:195-206, 1995
45. Yale JF, Grose M, Marliss EB: Time course of the lymphopenia in BB rats: relation to the onset of diabetes. Diabetes 34:955-959, 1985
46. Scollay RG, Butcher EC, Weissman IL: Thymus cell migration: quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur J Immunol 10:210-218, 1980
47. Modigliani Y, Coutinho G, Burlen-Defranoux O, Coutinho A, Bandeira A: Differential contribution of thynuc outputs and peripheral expansion in the development of peripheral T cell pools. Eur J Immunol 24:1223-1227, 1994
48. Groen H, Klatter FA, Brons NHC, Wubbena AK, Nieuwenhuis P, Kampinga J: High-frequency, but reduced absolute numbers of recent thymic migrants among peripheral blood T lymphocytes in diabetes-prone BB rats. Cell Immunol 163:113-119, 1995
49. Yang CP, Bell EB: Functional maturation of recent thymic emigrants in the periphery: development of alloreactivity correlates with the cyclic expression of CD45RC isoforms. Eur J Immunol 22:2261-2269, 1992
50. Liew FY, Cox FE: Nonspecific defence mechanism: the role of nitric oxide (Review). Immunol Today 12:A17-A21, 1991
51. Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC: Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS-expressing cells and relationships to cytokines expressed in the islets. Endocrinology 137:2093-2099, 1996
52. Suarez-Pinzon WL, Szabo C, Rabinovitch A: Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynirrite in pancreatic islet beta-cells. Diabetes 46:907-911, 1997
53. Kaneto H, Fujii J, Seo HG, Suzuki K, Matsuoka T, Nakamura H, Tatsumi H, Yamasaki Y, Kamada T, Taniguchi N: Apoptotic cell death triggered by nitric oxide in pancreatic beta cells. Diabetes 44:744-752, 1995
54. Rossini AA, Faustman D, Woda BA, Like AA, Szymanski I, Mordes JP: Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat J Clin Invest 74:39-46, 1984