Abnormalities in the export and fate of recent thymic emigrants in diabetes-prone BB/W rats

Autoimmunity

Volumn 24, Issue 1, 1996, Pages 35-46

  Zadeh, Homayoun H ^a   Greiner, Dale L ^b   Wu, Dianna Y ^a   Tausche, Frances ^a   Goldschneider, Irving ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Autoimmunity; Cellular differentiation; Cellular proliferation; Insulin dependent diabetes mellitus; Rat; Recent thymic emigrants; T lymphocytes

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FLUORESCEIN ISOTHIOCYANATE; PROPIDIUM IODIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; FEMALE; FLOW CYTOMETRY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; LYMPHOID TISSUE; MALE; NONHUMAN; PHENOTYPE; RAT; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; THYMUS;

EID: 0029959203     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939608995355     Document Type: Article

References (44)

1. Crisá, L., Mordes, J. P., Rossini, A. A. Autoimmune diabetes mellitus in the BB rat. Diabetes/Metab. 1992; 8: 9.
2. Woda, B. A., Padden, C. BioBreeding/Worcester (BB/ Wor) rats are deficient in the generation of functional cytotoxic T cells. J. Immunol. 1987; 139: 1514.
3. Bellgrau, D., Lagrade, A. C. Cytotoxic T-cell precursors with low-level CD8 in the diabetes-prone Biobreeding rat: implications for generation of an autoimmune T-cell repertoire. Proc. Natl Acad. Sci. (USA) 1990; 87: 313
4. Greiner, D. L., Handler, E. S., Nakano, K., Mordes, J. P., Rossini, A. A. Absence of the RT6 T cell subset in diabetes-prone BB/W rats. J. Immunol. 1986; 136: 148.
5. Georgiou, H. M., Bellgrau, D. Thymus transplantation and disease prevention in the diabetes-prone BioBreeding rat. J. Immunol. 1989; 142: 3400.
6. Georgiou, H. M., Lagarde, A. C., Bellgrau, D. T cell dysfunction in the diabetes-prone BB rat. A role for thymic migrants that are not T cell precursors. J. Exp. Med. 1988; 167: 132.
7. Jacob, H. J., Pattersson, A., Wilson, D., Mao, Y., Lernmark, A., Lander, E. S. Genetic dissection of autoimmune type I diabetes in the BB rat. Nature Genet. 1992; 2: 56.
8. Ono, S. J., Fuks, A., Guttmann, R. D., Colle, E. Susceptibility and resistance genes to insulin-dependent diabetes mellitus in the BB rat. Exp. Clin. Immunogenet. 1989; 6: 169.
9. Lang, F., Kastern, W. The gene for the T lymphocyte alloantigen, RT6, is not linked to either diabetes or lymphopenia and is not defective in the BB rat. Eur. J. Immunol. 1989; 19: 1785.
10. Rossini, A. A., Mordes, J. P., Greiner, D. L., Nakano, K., Appel, M. C., Handler, E. S. Spleen cell transfusion in the BB/W rat: Prevention of Diabetes, MHC restriction, and long term persistence of transfused cells. J. Clin. Invest. 1986; 77: 1399.
11. Burstein, D., Mordes, J. P., Greiner, D. L., Stein, D., Nakamura, N., Handler, E. S., Rossini, A. A. Prevention of diabetes in the BB/Wor rat by a single transfusion of spleen cells: Parameters that affect the degree of protection. Diabetes 1989; 38: 24.
12. + T lymphocytes induces diabetes in resistant BioBreeding/Worcester (BB/W) rats. J. Exp. Med. 1987; 166:461.
13. Markholst, H., Eastman, S., Wilson, D., Andreasen, B. E., Lernmark, A. Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes. J. Exp. Med. 1991; 174: 297.
14. Thomas, V. A., Woda, B. A., Handler, E. S., Greiner, D. L., Mordes, J. P., Rossini, A. A. Exposure to viral pathogenes alters the expression of diabetes in BB/Wor rats. Diabetes 1991; 40: 255.
15. Koch, F., Tiele, H. G., Low, M. G. Release of the rat T cell alloantigen RT-6.2 from cell membranes by phosphatidylinositol-specific phospholipase C. J. Exp. Med. 1986; 164: 1338.
16. Lubaroff, D. M., Greiner, D. L., Reynolds, C W. Investigations of T-lymphocyte subpopulations in the rat using allantigenic markers. Transplant. Proc. 1979; 11: 1092.
17. Greiner, D. L., Reynolds, C. W., Lubaroff, D. M. Maturation of functional T-lymphocyte subpopulations in the rat. Thymus 1982; 4: 77.
18. + cells in peripheral lymph nodes of DA rats. Transplant. Proc. 1987; 19: 3157.
19. + subset. Cell Immunol. 1988; 114: 336.
20. Koch, F., Haag, F., Thiele, H. G. Nucleotide and deduced amino acid sequence for the mouse homologue of the rat T-cell differentiation marker RT6. Nucleic Acids Res. 1990; 18: 3636.
21. Koch-Nolte, F., Hollmann, C., Kuhl, M., Haag, F., Prochazka, M., Leiter, E. H., Thiele, IH. G. Molecular polymorphism in the RT6 gene of laboratory mice correlates with the allotypes of the HI minor histocompatibility system. Immunogenetics 1995; 41: 152.
22. Hunt, H. D., Lubaroff, D. M. Identification of functional T cell subsets and surface antigen changes during activation as they relate to RT6. Cell Immunol. 1992; 88: 436.
23. Ernst, D. N., Luabaroff, D. M. Membrane antigen phenotype of sensitized T lymphocytes mediating tuberculin-delayed hypersensitivity in rats. Cell Immunol. 1984; 88: 346.
24. McKeever, U., Mordes, J. P., Greiner, D. L., Appel, M. C., Rozing, J., Handler, I. E. S., Rossini, A. A. Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. Proc. Natl Acad. Sci (USA) 1990; 87: 7618.
25. + T cell subset that inhibits this autoimmune potential. J. Exp. Med. 1993; 177: 627.
26. + T cells. J. Autoimmun. 1994; 7: 819.
27. + T cells. Develop. Immunol. 1991; 1: 191.
28. Hozzenizadeh, H., Goldschneider, I. Recent thymic emigrants in the rat express a unique antigenic phenotype and undergo post-thymic maturation in peripheral lymphoid tissues. J. Immunol. 1993; 150: 1670.
29. Groen, H., Klatter, F. A., Brons, N. H. C., Wubbena, A. S., Nieuwenhuis, P., Kampiga, J. High-frequency, but reduced absolute numbers of recent thymic migrants among peripheral blood T lymphocytes in diabetesprone BB rats. Cell Immunol. 1995; 163: 113.
30. Sarkar, P., Cirsa, L., McKeever, U., Bortell, R., Handler, E., Mordes, J. P., Waite, D., Schoenbaum, A., Haag, F., Koch-Nolte, I. F., Thiele, H. G., Greiner, D. L., Rossini, A. A. Loss of RT6 message and most circulating T cells after thymectomy of diabetes prone BB rats. Autoimmunity 1994; 18: 15.
31. + cells. J. Immunol. 1990; 144: 923.
32. Brideau, R. J., Carter, P. B., McMaster, W. R., Mason, D. W., Willisam, A. F. Two sets of rat T lymphocytes defined with monoclonal antibodies. Eur. J. Immunol. 1980; 10: 609.
33. Hunig, T., Wallnly, H. J., Hartley, J. K., Lawetzky, A., Tiefenthaler, G. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes. J. Exp. Med. 1989; 169: 73.
34. Mason, E. W., Williams, A. F. The kinetics of antibody binding to membrane antigens in solution at the cell surface. Biochemical Journal 1980; 187: 1.
35. Nicolls, M. R., Aversa, G. A., Pearce, N. W., Spinelli, A., Berber, M. F., Curley, K. E., Hall, B. M. Induction of long term specific tolerance to allografts in vivo by therapy with a monoclonal antibody to rat CD3. Transplant 1993; 55: 459.
36. Bayer, E., Wilcheck, M. Isolubilized biotin for the purification of avidin. In: Jakoby, W. B., Wilcheck, M., eds. Methods in Enzymology Volume 34. New York: Academic Press, 1974: 265.
37. Noguchi, P. D. Use of flow cytometry for DNA analysis. In: Coico, R., ed. Current Protocols in Immunology. Unit 5.7. New York: John Wiley and Sons., 1991.
38. + gene is transcribed and translated in lymphopenic diabetes prone BB rats. Diabetes 1993; 42: 633.
39. + T cells in diabetes-prone BioBreeding/ Worcester rats is due to genetic and cell developmental defects. J. Immunol. 1988; 141: 4146.
40. Rozing, J., Coolen, C., Tielen, J., Weegenaar, J., Schuurman, H. J., Greiner, D. L., Rossini, A. A. Defects in the thymic epithelial stroma of diabetes prone BB rats. Thymus 1989; 140: 125.
41. Whalen, B. J., Rossini, A. A., Mordes, J. P., Greiner, D. L. DR BB rat thymus contains thymocyte populations predisposed to autoreactivity. Diabetes 1995; 44: 963.
42. Doukas, J., Mordes, J. P., Swymer, C., Niedzwiecki, D., Mason, R., Rozing, J., Rossini, A. A., Greiner, D. L. Thymic epithelial defects and predisposition to autoimmune disease in BB rats. Am. J. Pathol. 1994; 145: 1517.
43. - TCR alpha beta intermediate T cells in the liver of normal adult mice: implications for lpr pathogenesis. Internatl. Immunol. 1994; 6: 533.
44. + cytotoxic T cells. Proc. Natl Acad. Sci. (USA) 1994; 91: 485.