Regulation of n-3 and n-6 fatty acid metabolism in retinal and cerebral microvascular endothelial cells by high glucose

Journal of Neurochemistry

Volumn 70, Issue 2, 1998, Pages 841-849

  Delton Vandenbroucke, Isabelle ^a,b,c   Grammas, Paula ^a,b   Anderson, Robert E ^a,b,c  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Arachidonic acid; Desaturation; Docosahexaenoic acid; High glucose levels; Microvascular endothelial cells

Indexed keywords

ARACHIDONIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CELL METABOLISM; ENDOTHELIUM CELL; FATTY ACID DESATURATION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; RETINA BLOOD FLOW; RETINA CAPILLARY; VASCULAR ENDOTHELIUM;

ANIMALIA;

EID: 0031912894     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70020841.x     Document Type: Article

References (36)

1. Affolter V., Boujon P., Bestetti G., and Rossi G. L. (1986) Hypothalamic and cortical neurons of normotensive and spontaneously hypertensive rats are differently affected by streptozotocin diabetes. Acta Neuropathol. (Berl.) 70, 135-141.
2. Alexander-North L., North J. A., Kiminyo K. P., Buettner G. R., and Spector A. A. (1994) Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells. J. Lipid Res. 35, 1773-1785.
3. Anderson R. E. (1970) Lipids of ocular tissues. IV. A comparison of the phospholipids from the retina of six mammalian species. Eye Exp. Res. 10, 339-344.
4. Benistant C., Dehouck M. P., Fruchart J. C., Ceccheli R., and Lagarde M. (1995) Fatty acid composition of brain capillary endothelial cells: effect of the coculture with astrocytes. J. Lipid Res. 36, 2311-2319.
5. Chen H. and Anderson R. E. (1992) Quantification of phenacyl esters of retinal fatty acids by high-performance liquid chromatography. J. Chromatogr. 578, 124-129.
6. Delton-Vandenbroucke I., Grammas P., and Anderson R. E. (1997) Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells. J. Lipid Res. 38, 147-159.
7. Devaskar S., Zahm D. S., Holtzclaw L., Chindu K., and Wadzinski B. E. (1991) Developmental regulation of the distribution of rat brain insulin-insensitive (Glut 1) glucose transporter. Endocrinology 129, 1530-1540.
8. Diglio C. A., Liu W., Grammas P., Giacomelli F., and Wiener J. (1993) Isolation and characterization of cerebral resistance vessel endothelium in culture. Tissue Cell 25, 833-846.
9. Fliesler S. J. and Anderson R. E. (1983) Chemistry and metabolism of lipids in the vertebrate retina. Prog. Lipid Res. 22, 79-131.
10. Futterman S. and Kupfer C. (1968) The fatty acid composition of the retinal vasculature of normal and diabetic human eyes. Invest. Ophthalmol. 7, 105-108.
11. Futterman S., Rollins M. H., and Vacano E. (1968) The effect of alloxan diabetes on polyenoic fatty acid synthesis by retinal tissue. Biochim. Biophys. Acta 164, 433-434.
12. Futterman S., Sturtevant R., and Kupfer C. (1969) Effect of alloxan diabetes on the fatty acid composition of the retina. Invest. Ophthalmol. 8, 542-544.
13. Geiger M., Mohammed B. S., Sankarappa S., and Sprecher H. (1993) Studies to determine if rat liver contains chain-length-specific acyl-CoA 6-desaturases. Biochim. Biophvs. Acta 1170, 137-142.
14. Hrelia S., Biagi P. L., Turchetto E., Rossi C. A., and Bordoni A. (1992) Protein kinase C activity in neonatal cultured rat cardiomyocytes supplemented with docosahexaenoic acid. Biochem. Biophys. Res. Commun. 183, 893-898.
15. Kowluru R. A., Kern T. S., and Engerman R. L. (1997) Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system. Free Radic. Biol. Med. 22, 587-592.
16. Lecomte M., Paget C., Ruggiero D., Wiernsperger N., and Lagarde M. (1996) Docosahexaenoic acid is a major n-3 polyunsaturated fatty acid in bovine retinal microvessels. J. Neurochem. 66, 2160-2167.
17. Lee T., Saltsman K. A., Ohashi H., and King G. L. (1989) Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. Proc. Natl. Acad. Sci. USA 86, 5141-5145.
18. Mandarino L. J., Finlayson J., and Hassell J. R. (1994) High glucose downregulates glucose transport activity in retinal capillary pericytes but not endothelial cells. Invest. Ophthalmol. Vis. Sci. 35, 964-972.
19. Mimouni V. and Poisson J. P. (1990) Spontaneous diabetes in BB rats: evidence for insulin dependent liver microsomal delta 6 and delta 5 desaturase activities. Horm. Metab. Res. 22, 405-407.
20. Mooradian A. D. (1997) Central nervous system complications of diabetes mellitus - a perspective from the blood-brain barrier. Brain Res. Rev. 23, 210-218.
21. Mooradian A. D. and Smith T. L. (1992) The effect of experimentally induced diabetes mellitus on the lipid order and composition of rat cerebral microvessels. Neurosci. Lett. 145, 145-148.
22. Moore S. A., Hurt E., Yoder E., Sprecher H., and Spector A. A. (1995) Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid. J. Lipid Res. 36, 2433-2443.
23. Mori T., Takai Y., Yu B., Takahashi J., Nishizuka Y., and Fujikara T. (1982) Specificity of the fatty acyl moieties of diacylglycerol for the activation of calcium-activated, phospholipid-dependent protein kinase. J. Biochem. (Tokyo) 91, 427-431.
24. Morrison W. R. and Smith L. M. (1964) Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron trifluoride methanol. J. Lipid Res. 5, 600-608.
25. O'Brien J. S. and Sampson E. L. (1965) Fatty acid and aldehyde composition of the major brain lipids in normal gray matter, white matter and myelin. J. Lipid Res. 6, 545-551.
26. Rosenthal M. D. and Hill J. R. (1984) Human vascular endothelial cells synthesize and release 24- and 26-carbon polyunsaturated fatty acids. Biochim. Biophys. Acta 795, 171-178.
27. 24:5,n-3 fatty acid in retina. Biochem. J. 316, 859-864.
28. Rymaszewski Z., Szymanski P. T., Abplanalp W. A., Myatt L., Di Salvo J. and Cohen R. M. (1991) Human retinal vascular cells differ from umbilical cells in synthetic functions and their response to glucose. Proc. Soc. Exp. Biol. Med. 199, 183-191.
29. Stitt A. W., Li Y. M., Gardiner T. A., Bucala R., Archer D. B., and Vlassara H. (1997) Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats. Am. J. Pathol. 150, 523-531.
30. Takakura Y., Kuentzel S. L., Raub T. J., Davies A., Baldwin S. A., and Borchardt R. T. (1991) Hexose uptake in primary cultures of bovine brain microvessel endothelial cells. I. Basic characteristics and effects of D-glueose and insulin. Biochim. Biophys. Acta 1070, 1-10.
31. Van den Enden M. K., Nyengaard J. R., Ostrow E., Burgan J. H., and Williamson J. R. (1995) Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 36, 1675-1685.
32. Wang N. and Anderson R. E. (1993) Synthesis of docosahexaenoic acid by retina and retinal pigment epithelium. Biochemistry 32, 13703-13709.
33. Wetzel M. G., Li J., Alvarez R. A., Anderson R. E., and O'Brien P. J. (1991) Metabolism of linolenic acid and docosahexaenoic acid in rat retinas and rod outer segments. Exp. Eye Res. 53, 437-446.
34. Wiegand R. D. and Anderson R. E. (1982) Determination of molecular species of rod outer segment phospholipids. Methods Enzymol. 81, 297-304.
35. Wood R. and Lee T. (1983) High-performance liquid chromatography of fatty acids: quantitative analysis of saturated, monoenoic, polyenoic and geometrical isomers. J. Chromatogr. 254, 237-246.
36. +-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. J. Clin. Invest. 96, 733-740.