Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells

Journal of Lipid Research

Volumn 38, Issue 1, 1997, Pages 147-159

  Delton Vandenbroucke, Isabelle ^a,b,c   Grammas, Paula ^a,b   Anderson, Robert E ^a,b,c  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

chain elongation; desaturation; docosahexaenoic acid; docosapentaenoic acid; fetal bovine serum; retroconversion

Indexed keywords

DOCOSAHEXAENOIC ACID; POLYUNSATURATED FATTY ACID;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN MICROCIRCULATION; COW; ENDOTHELIUM CELL; FATTY ACID DESATURATION; FATTY ACID METABOLISM; LIPID COMPOSITION; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA CELL;

ANIMALS; BLOOD PHYSIOLOGY; BRAIN; CATTLE; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; DOCOSAHEXAENOIC ACIDS; ENDOTHELIUM, VASCULAR; FATTY ACIDS, UNSATURATED; MICROCIRCULATION; RADIOLIGAND ASSAY; RATS; RETINA;

EID: 0031030077     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. O'Brien, J. S., and E. L. Sampson. 1965. Fatty acid and aldehyde composition of the major brain lipids in normal grey matter, white matter and myelin. J. Lipid Res. 6: 545-552.
2. Anderson, R. E. 1970. Lipids of ocular tissues IV. A comparison of the phospholipids from the retina of six mammalian species. Eye Exp. Res. 10: 339-344.
3. Salem, N., Jr., H. Y. Kim, and J. A. Yergey. 1986. Docosahexaenoic acid: membrane function and metabolism. In Health Effects of Polyunsaturated Fatty Acids in Seafoods. A. P. Simopoulos, R. R. Kifer and R. Martin, editors. Academic Press, New York. 15: 263-313.
4. Fliesler, S. J., and R. E. Andersons. 1983. Chemistry and metabolism of lipids in the vertebrate retina. Prog. Lipid Res. 22: 79-131.
5. Bourre, J. M., M. Bonneil, M. Clement, O. Dumont, G. Durand, H. Lafont, G. Nalbone, and M. Piciotti. 1990. Function of dietary polyunsaturated fatty acids in the nervous system. Prostaglandins Leukot. Essent. Fatty Acids. 48: 5-15.
6. Connor, W. E., M. Neuringer, and S. Reisbick. 1992. Essential fatty acids: the importance of n-3 fatty acids in the retina and brain. Nutr. Rev. 50: 21-29.
7. Salem, N., Jr., and G. R. Ward. 1993. Are ω3 fatty acids essential nutrients for mammals? In Nutrition and Fitness in Health and Disease. World Rev. Nutr. Diet. A. P. Simopoulos, editor. Karger, Basel. 128-147.
8. Naughton, J. M. 1981. Supply of polyenoic fatty acids to the mammalian brain: the ease of conversion of the short-chain essential fatty acids to their longer chain polyunsaturated metabolites in liver, brain, placenta and blood. Int. J. Biochem. 13: 21-32.
9. Nouvelot, A., C. Delbart, and J. M. Bourre. 1986. Hepatic metabolism of dietary alpha-linolenic acid in suckling rats, and its possible importance in polyunsaturated fatty acid uptake by the brain. Ann. Nutr. Metab. 30: 316-323.
10. Scott, B. L., and N. G. Bazan. 1989. Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. Proc. Natl. Acad. Sci. USA. 86: 2903-2907.
11. Bazan, H. E. P., M. M. Careaga, H. Sprecher, and N. G. Bazan. 1982. Chain elongation and desaturation of eicosapentaenoate to docosahexaenoate and phospholipid labeling in the rat retina in vivo. Biochim. Biophys. Acta. 712: 123-128.
12. Wetzel, M. G., J. Li, R. A. Alvarez, R. E. Anderson, and P. J. O'Brien. 1991. Metabolism of linolenic acid and docosahexaenoic acid in rat retinas and rod outer segments. Exp. Eye Res. 53: 437-446.
13. Alvarez, R. A., G. D. Aguirre, G. M. Acland, and R. E. Anderson. 1994. Docosapentaenoic acid is converted to docosahexaenoic acid in the retinas of normal and prcd-affected miniature poodle dogs. Invest. Ophthalmol. Vis. Sci. 35: 402-408.
14. Wang, N., and R. E. Anderson. 1993. Synthesis of docosahexaenoic acid by retina and retinal pigment epithelium. Biochemistry. 32: 13703-13709.
15. Green, P., and E. Yaven. 1993. Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. J. Lipid Res. 34: 2099-2107.
16. Pawlosky, R. J., G. Ward, and N. Salem, Jr. 1996. Essential fatty acid uptake and metabolism in the developing rodent brain. Lipids. 31: S-103-107.
17. Moore, S. A., E. Yoder, S. Murphy, G. R. Dutton, and A. A. Spector. 1991. Astrocytes, not neurons, produce docosahexaenoic acid (22:6n-3) and arachidonic acid (20: 4n-6). J. Neurochem. 56: 518-524.
18. Bénistant, C., M. P. Dehouck, J. Fruchart, R. Cechelli, and M. Lagarde. 1995. Fatty acid composition of brain capillary endothelial cells: effect of the coculture with astrocytes. J. Lipid Res. 36: 2311-2319.
19. Lecomte, M., C. Paget, D. Riggiero, N. Wiernsperger, and M. Lagarde. 1996. Docosahexaenoic acid is a major n-3 polyunsaturated fatty acid in bovine retinal microvessels. J. Neurochem. 66: 2160-2167.
20. Moore, S. A., E. Yoder, and A. A. Spector. 1990. Role of the blood-brain barrier in the formation of long-chain n-3 and n-6 fatty acids from essential fatty acid precursors. J. Neurochem. 55: 391-402.
21. Gitlin, J. D., and P. A. D'Amore. 1983. Culture of retinal capillary cells using selective growth media. Microvasc. Res. 26: 74-80.
22. Diglio, C. A., W. Liu, P. Grammas, F. Giacomelli, and J. Wiener. 1993. Isolation and characterization of cerebral resistance vessel endothelium in culture. Tissue cell. 25: 833-846.
23. Voyta, J. C., D. P. Via, C. E. Butterfield, and B. R. Zetter. 1984. Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein. J. Cell. Biol. 99: 2034-2040.
24. Diglio, C. A., P. Grammas, F. Giacomelli, and J. Wiener. 1982. Primary culture of rat cerebral microvascular endothelial cells. Lab. Invest. 46: 554-563.
25. Wood, R., and T. Lee. 1983. High-performance liquid chromatography of fatty acids: quantitative analysis of saturated, monoenoic, polyenoic and geometrical isomers. J. Chromatogr. 254: 237-246.
26. Morrison, W. R., and L. M. Smith. 1964. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J. Lipid Res. 5: 600-608.
27. Chen, H., and R. E. Anderson. 1992. Quantification of phenacyl esters of retinal fatty acids by high-performance liquid chromatography. J. Chromatogr. 578: 124-129.
28. Moore, S. A. 1994. Local synthesis and targeting of essential fatty acids at the cellular interface between blood and brain: a role for cerebral endothelium and astrocytes in the accretion of CNS docosahexaenoic acid. In Fatty Acids and Lipids: Biological Aspects. World Rev. Nutr. Diet. C. Galli, A. P. Simopoulos, E. Tremoli, editors. Karger, Basel. 75: 128-133.
29. Voss, A., M. Reinhart, S. Sankarappa, and H. Sprecher. 1991. The metabolism of 7, 10, 13, 16, 19-docosapentaenoic acid to 4, 7, 10, 13, 16, 19-docosahexaenoic acid in rat liver is independent of a δ4-desaturase. J. Biol. Chem. 266: 19995-20000.
30. Moore, S. A., E. Hurt, E. Yoder, H. Sprecher, and A. A. Spector. 1995. Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid. J. Lipid Res. 36: 2433-2443.
31. Rosenthal, M. D., and J. R. Hill. 1984. Human vascular endothelial cells synthesize and release 24-and 26-carbon polyunsaturated fatty acids. Biochim. Biophys. Acta. 795: 171-178.
32. Achard, F., C. Bénistant, and M. Lagarde. 1995. Interconversions and distinct metabolic fate of eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in bovine aortic endothelial cells. Biochim. Biophys. Acta. 1255: 260-266.
33. Moore, S. A. 1993. Cerebral endothelium and astrocytes cooperate in supplying docosahexaenoic acid to neurons. Adv. Exp. Med. Biol. 331: 229-233.
34. Stoll, L. L., and A. A. Spector. 1984. Changes in serum influence the fatty acid composition of established cell lines. In Vitro. 20: 732-738.
35. Rosenthal, M. D., and M. C. Whitehurst. 1983. Fatty acyl δ6 desaturation activity of cultured human endothelial cells modulation by fetal bovine serum. Biochim. Biophys. Acta. 750: 490-496.
36. Vossen, R. C. R. M., M. C. E. Van Dam-Mieras, P. J. M. R. Lemmens, G. Hornstra, and R. F. A. Zwaal. 1991. Membrane fatty acid composition and endothelial cell functional properties. Biochim. Biophys. Acta. 1083: 243-251.
37. Dias, V. C., and H. G. Parsons. 1995. Modulation in δ9, δ6, and δ5 fatty acid desaturase activity in the human intestinal CaCo-2 cell line. J. Lipid Res. 36: 552-563.
38. Cook, H. W., J. T. R. Clarke, and M. W. Spence. 1983. Concerted stimulation and inhibition of desaturation, chain elongation, and esterification of essential fatty acids by cultured neuroblastoma cells. J. Biol. Chem. 258: 7586-7591.
39. Teruya, J., J. Cluette-Brown, Z. M. Szczepiorkowski, and M. Laposata. 1995. Mode of transport of fatty acid to endothelial cells influences intracellular fatty acid metabolism. J. Lipid Res. 36: 266-276.
40. Veerkamp, J. H., and R. G. H. J. Maatman. 1995. Cytoplasmic fatty acid-binding proteins: their structure and genes. J. Lipid Res. 34: 17-52.
41. Brenner, R. R. 1990. Endocrine control of fatty acid desaturation. Biochem. Soc. Trans. 18: 773-775.