Relative neurotoxicological properties of five unsaturated aliphatic nitriles in rats

Journal of Applied Toxicology

Volumn 18, Issue 1, 1998, Pages 25-31

  Gagnaire, F ^a   Marignac, B ^a   Bonnet, P ^a  

^a INSTITUT NATIONAL DE RECHERCHE ET DE SÉCURITÉ   (France)

Author keywords

Aliphatic nitriles; Neurotoxicity; Peripheral neuropathy; Rat

Indexed keywords

ACRYLONITRILE; METHACRYLONITRILE; NITRILE;

ACTION POTENTIAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HINDLIMB; HYPERACTIVITY; INHALATION; LOCOMOTION; MALE; MOTOR NERVE CONDUCTION; MUSCLE WEAKNESS; NEUROTOXICITY; NEUROTOXICOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SALIVATION; SENSORY NERVE CONDUCTION; TAIL;

ACRYLONITRILE; ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; HINDLIMB; HYPERKINESIS; MALE; METHACRYLATES; MOTOR ACTIVITY; NITRILES; PERIPHERAL NERVES; RATS; RATS, SPRAGUE-DAWLEY; SALIVATION; STEREOTYPED BEHAVIOR; STRUCTURE-ACTIVITY RELATIONSHIP; TAIL; TIME FACTORS;

EID: 0031911853     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199801/02)18:1<25::AID-JAT466>3.0.CO;2-V     Document Type: Article

References (30)

1. J. F. Brazdil, Acrylonitrile. In Kirk-Othmer Encyclopedia of Chemical Technology, 4th Edn. Vol I, pp. 352-369 Wiley, New York (1991).
2. M Y H. Farooqui and M. M. Mumtaz, Toxicology of methacrylonitrile. Toxicology 65, 239-250 (1991).
3. J. L O'Donognue, Cyanide, nitriles and isocyanates. In Neurotoxicity of Industrial and Commercial Chemicals, ed. by J. L. O'Donoghue, Vol. II, pp. 25-37. CRC Press, Boca Raton, FL (1985).
4. J. L. Cadet, The iminodipropionitrile (IDPN)-induced dyskinetic syndrome: behavioral and biochemical pharmacology. Neurosci. Behav Rev. 13, 39-45 (1989)
5. H. Tanii, Y. Kurosaka, M. Hayashi and K. Hashimoto, Allylnitrile: a compound which induce long-term dyskinesia in mice following a single administration Exp. Neurol 103, 64-67 (1989).
6. H. Tanii, M. Hayashi and K. Hashimoto, Nitrile-induced behavioral abnormalities in mice Neurol. Toxicol. 10, 157-166 (1989).
7. H Tanii, M. Hayashi and K. Hashimoto, Alterations in the metabolism of serotonin and dopamine in the central nervous system of mice displaying a persistent dyskinesia due to crotononitrile or 2-pentenenitrile. Arch. Toxicol. 64, 213-236 (1990).
8. H. Tanii, M. Hayashi and K. Hashimoto, Behavioral syndrome induced by allylnitrile, crotononitrile or 2-pentenenitrile in rats Neuropharmacology 30, 887-892 (1991).
9. H. Tanii, K. Hashimoto and A. Harada, Effect of carbon tetrachloride on allylnitrile-induced head twitching. Environ. Res. 61, 140-149 (1993)
10. S. M. Chou and H. A Hartmann, Axonal lesions and waltzing syndrome after IDPN administration in rats. Acta Neuropathol. (Berlin) 3, 428-450 (1964)
11. S. M. Chou and H. A. Hartmann, Electron microscopy of focal neuroaxonal lesions produced by β,β′-iminodipropionitrile (IDPN) in rats Acta Neuropathol. (Berlin) 4, 590-603 (1965).
12. A W. Clark, J. W. Griffin and D. L Price, The axonal pathology in chronic IDPN intoxication. J. Neuropathol. Exp. Neurol. 39, 42-55 (1980).
13. J. W. Griffin and D. L. Price, Demyelmation in experimental β,β′-iminodipropionitrile and hexacarbon neuropathies. Evidence for an axonal influence. Lab. Invest. 45, 130-141 (1981).
14. E. Hofinger, P. M. Le Quesne, T. Gajree, Conduction velocity in nerve fibres with axonal atrophy due to chronic β-β′-iminodipropionitrile (IDPN). J. Neurol. Sci 53, 159-167 (1982).
15. H. E. Lowndes, D. A. Delio and B. G. Gold, Electrophysiological investigation of IDPN neuropathy. Initial studies. Neurol. Toxicol. 6, 25-42 (1985)
16. K. Knobloch, S. Szendzikowski, T. Gzajkowska and B. Krysiak, Experimental studies on acute and subacute toxicity of acrylonitrile. Med. Prac. 22, 257-269 (1971).
17. B. Krysiak and K. Knobloch, The effect of acrylonitrile on the central nervous system. Med. Prac. 22, 601-610 (1971).
18. A. E. Ahmed and M. Y. H. Farooqui, Comparative toxicities of aliphatic nitriles. Toxicol. Lert 12, 157-163 (1982).
19. B I. Ghanayem, M. Y. H. Farooqui, O. Elshabrawy, M. M Mumtaz and A. E. Ahmed, Assessment of the acute acrylonitrile-induced neurotoxicity in rats. Neurotoxicol. Teratol. 13, 499-502 (1991).
20. H C. Dudley, T. R. Sweeney and J. W. Miller, Toxicology of acrylonitrile (vinyl cyanide). II. Studies of effects of daily inhalation. J. Ind. Hyg. Toxicol. 24, 255-258 (1942).
21. J F. Quast, C E Wade, C. G. Humiston, R. M. Carreon, E. A. Hermann, C. N. Park and B. A. Schwetz, A two-year toxicity and oncogenicity study with acrylonitrile incorporated in the drinking water of rats. Final Report. Dow Toxicology Research Laboratory, Midland, MI (1980).
22. H. E. Lowndes, T. Baker, L. P. Michelson and M. Vincent-Ablazey, Attenuated dynamic responses of primary endings of muscle spindles: a basis for depressed tendon responses in acrylamide neuropathy. Ann. Neurol. 3, 433-437 (1978).
23. H. A. Tilson and P A. Cabe, The effects of acrylamide given acutely or in repeated doses on fore- and hind-limb function of rats. Toxicol. Appl. Pharmacol. 47, 253-260 (1979).
24. R. J. Anderson, Peripheral nerve velocities and excitability. In Electrophysiology in Neurotoxicology, ed. by H. E. Lowndes, Vol. II, pp. 51-59. CRC Press, Boca Raton, FL (1987).
25. P W Langvert, C. L. Putzig, W. H. Braun and J. D. Young, Identification of the major urinary metabolites of acrylonitrile in the rat. J. Toxicol. Environ. Health 6, 273-282 (1980).
26. B. I. Ganayem, I. M. Sanchez and L. T. Burka, Effects of dose, strain and dosing vehicle on methacrylonitrile disposition in rats and identification of a novel-exhaled metabolite. Drug Metab. Dispos. 20, 643-652 (1992).
27. L. T. Burka, I. M. Sanchez, A. E. Ahmed and B. I. Ghanayem, Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats. Arch. Toxicol. 68, 611-618 (1994).
28. B. I Ghanayem, I. M. Sanchez and L. T. Burka, Investigation of methacrylonitrile metabolism and the metabolic basis for the differences in its toxicity in rats and mice. J. Pharmacol. Exp. Ther. 269, 581-588 (1994).
29. A. E. Ahmed, S. Jacob and B. I. Ghanayem, Comparative disposition of acrylonitrile and methacrylonitrile: quantitative whole body autoradiographic studies in rats. Fundam. Appl. Toxicol. 33, 49-59 (1996).
30. B I. Ghanayem and L. T. Burka, Excretion and identification of methacrylonitrile metabolites in the bile of F-344 rats. Drug Metab. Dispos. 24, 390-394 (1996).