Rearrangements of the high mobility group protein family genes and the molecular genetic origin of uterine leiomyomas and endometrial polyps

Molecular Human Reproduction

Volumn 2, Issue 4, 1996, Pages 277-283

  Hennig, Yvonne ^a   Wanschura, Sylke ^a   Deichert, Ulrich ^b   Bartnitzke, Sabine ^a   Bullerdiek, Jörn ^a  

^a UNIVERSITY OF BREMEN   (Germany)

^b Central Hospital   (Germany)

Author keywords

Endometrial polyps; Gene rearrangement; High mobility group proteins; Uterine leiomyomas

Indexed keywords

HIGH MOBILITY GROUP PROTEIN;

ARTICLE; CHROMOSOME 12; CHROMOSOME MAP; ENDOMETRIUM TUMOR; FEMALE; GENE REARRANGEMENT; GENETICS; HUMAN; KARYOTYPING; LEIOMYOMA; POLYP;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 12; ENDOMETRIAL NEOPLASMS; FEMALE; GENE REARRANGEMENT; HIGH MOBILITY GROUP PROTEINS; HUMANS; KARYOTYPING; LEIOMYOMA; POLYPS;

EID: 0030112498     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/2.4.277     Document Type: Article

References (58)

1. Ashar, H.R., Schoenberg Fejzo, M., Tkachenko, A. et al. (1995) Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell, 82, 57-65.
2. Bartram, C.R., de Klein, A., Hagemeijer, A. et al. (1983) Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukemia. Nature, 306, 277-280.
3. Berlingieri, M.T., Manfiloletti, G., Santoro, M. et al. (1995) Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells. Mol. Cell. Biol., 15, 1545-1553.
4. Boghosian, L., Dal Cin, P. and Sandberg, A.A. (1988) An interstitial deletion of chromosome 7 may characterize a subgroup of uterine leiomyoma. Cancer Genet. Cytogenet., 34, 207-208.
5. Bol, S., Wanschura, S., Thode, B. et al. (1996) An endometrial polyp with a rearrangement of HMGI-C underlying a complex cytogenetic rearrangement involving chromosome 2 and 12. Cancer Genet. Cytogenet., in press.
6. Bullerdiek, J., Wobst, G., Meyer-Bolte, K. et al. (1993) Cytogenetic subtyping of 220 salivary gland pleomorphic adenomas: correlation to occurrence histological subtype, and in vitro cellular behavior. Cancer Genet. Cytogenet., 65, 27-31.
7. Bustin, M., Lehn, D.A. and Landsman, D. (1990) Structural features of the HMG chromosomal proteins and their genes. Biochem. Biophys. Acta, 1049, 231-243.
8. Croce, C.M., Tsujimoto, Y. and Novrell, P.C. (1986) Molecular mechanisms involved in human B- and T-cell neoplasia. Gene Amplification Anal., 4, 143-160.
9. Dal Cin, P., Kools, P., De Jonge, I. et al. (1993) Rearrangements of 12q14-15 in pulmonary chondroid hamartoma. Genes Chrom. Cancer, 8, 131-133.
10. Dal Cin, P, Vanni, R., Marras, S. et al. (1995) Four cytogenetic subgroups can be identified in endometrial polyps. Cancer Res., 55, 1565-1568.
11. Fan, S.-X., Sreekantaiah, C., Berger, C.S. et al. (1990) Cytogenetic findings in nine leiomyomas of the uterus. Cancer Genet. Cytogenet., 47, 179-189.
12. Friedman, M., Holth, L.T., Zoghbi, H.Y. and Reeves, R. (1993) Organization, inducible-expression and chromosome localization of the human HMGI (Y) nonhistone protein gene. Nucl. Acids. Res., 21, 4259-4267.
13. Gibas, Z., Griffin, C.A. and Emanuel, B.S. (1988) Clonal chromosome rearrangements in a uterine myoma. Cancer Genet. Cytogenet., 32, 19-24.
14. Hashimoto, K., Azuma, C., Kamiura, S. et al. (1995) Clonal determination of uterine leiomyomas by analyzing differential inactivation of the X-chromosome-linked phosphoglycerokinase gene. Gynecol. Obstet. Invest., 40, 204-208.
15. Heim, S., Nilbert, M., Vanni, R. et al. (1988) A specific translocation, t(12; 14) (q14-15;q23-24), characterizes a subgroup of uterine leiomyomas. Cancer Genet. Cytogenet., 32, 13-17.
16. Hu, J. and Surti, U. (1991) Subgroups of uterine leiomyomas based on cytogenetic analysis. Hum. Pathol., 22, 1009-1016.
17. Kazmierczak, B., Bartnitzke, S., Hartl, M. and Bullerdiek, J. (1990) In vitro transformation by the SV 40 early region of cells from human benign salivary gland tumour with a 12q13-15 rearrangement. Cytogenet. Cell Genet., 53, 37-39.
18. Kazmierczak, B., Wanschura, S., Rosigkeit, J. et al. (1995a) Molecular characterization of 12q14-15 rearrangements in three pulmonary chondroid haemartomas. Cancer Res., 55, 2497-2499.
19. Kazmierczak, B., Hennig, Y., Wanschura, S. et al. (1995b) Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the High Mobility Group Proteins, and the mitochondrial aldehyde dehydrogenase gene. Cancer Res., 55, 6038-6039.
20. Kiechle-Schwarz, M., Sreekantaiah, C., Berger, C.S. et al. (1991) Nonrandom cytogenetic changes in leiomyomas of the female genitourinary tract. Cancer Genet. Cytogenet., 53, 125-136.
21. Linder, D. and Gartker, S.M. (1965) Glucose-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomas. Science, 150, 67-69.
22. Mandahl, N., Heim, S., Arheden, K. et al. (1988) Three major cytogenetic subgroups can be identified among chromosomally abnormal solitary lipomas. Hum. Genet., 79, 203-208.
23. Mark, J. and Dahlenfors, R. (1986) Cytogenetical observations in 100 human benign pleomorphic adenomas: Specificity of the chromosomal aberrations and their relationship to sites of localized oncogenes. Anticancer Res., 6, 299-308.
24. Mark, J., Havel, G., Grepp, C. et al. (1988) Cytogenetical observations in human benign uterine leiomyomas. Anticancer Res., 8, 621-626.
25. Mark, J., Havel, G., Grepp, C. et al. (1990) Chromosomal patterns in human benign uterine leiomyomas. Cancer Genet. Cytogenet., 44, 1-13.
26. Mark, J., Havel, G., Dahlenfors, R. and Wedell, B. (1991) Cytogenetics of multiple uterine leiomyomas, parametrial leiomyoma and disseminated peritoneal leiomyomatosis. Anticancer Res., 11, 33-40.
27. Meloni, A.M., Surti, U. and Sandberg, A.A. (1991) Deletion of chromosome 13 in leiomyomas of the uterus. Cancer Genet. Cytogenet., 53, 199-203.
28. Meloni, A.M., Surti, U., Contento, A.M. et al. (1992) Uterine leiomyomas: cytogenetic and histologic profile. Obstet. Gynecol., 2, 209-217.
29. Mugneret, F., Lizard-Nacol, S., Volk, C. et al. (1988) Association of breakpoint 14q23 with uterine leiomyoma. Cancer Genet. Cytogenet., 34, 201-206.
30. Nilbert, M. and Strömbeck, B. (1992) Independent origin of uterine leiomyomas with karyotypically identical alterations. Gynecol. Obstet. Invest., 33, 246-248.
31. Nilbert, M., Heim, S., Mandahl, N. et al. (1988) Karyotypic rearrangements in 20 uterine leiomyomas. Cytogenet. Cell Genet., 49, 300-304.
32. Nilbert, M., Heim, S., Mandahl, N. et al. (1989a) Different karyotypic abnormalities, t(1;6) and del(7), in two uterine leiomyomas from the same patient. Cancer Genet. Cytogenet., 42, 51-53.
33. Nilbert, M., Heim, S., Mandahl, N.et al. (1989b) Complex karyotypic anomalies in a bizarre leiomyoma of the uterus. Genes Chrom. Cancer, 1, 131-134.
34. Nilbert, M., Heim, S., Mandahl, N. et al. (1990a) Trisomy 12 in uterine leiomyomas. Cancer Genet. Cytogenet., 45, 63-66.
35. Nilbert, M., Heim, S., Mandahl, N. et al. (1990b) Characteristic chromosome abnormalities, including rearrangements of 6p, del(7q), +12, and t(12;14), in 44 uterine leiomyomas. Hum. Genet., 85, 605-611.
36. Norris, H.J. and Zaloudek, C.-J. (1982) Mesenchymal tumour of the uterus. In Blaustein, A. (ed.), Pathology of female Genital Tract. 2nd edn. Springer Verlag, Berlin, pp. 352-392.
37. Ozisik, Y.Y., Meloni, A.M., Surti, U. and Sandberg, A.A. (1993) Involvement of 10q22 in leiomyoma. Cancer Genet. Cytogenet., 69, 132-135.
38. Pandis, N., Heim, S., Bardi, G. et al. (1990) Parallel karyotypic evolution and tumor progression in uterine leiomyoma. Genes Chrom. Cancer, 2, 311-317.
39. Pandis, N., Heim, S., Bardi, G. et al. (1991) Chromosome analysis of 96 uterine leiomyomas. Cancer Genet. Cytogenet., 55, 11-18.
40. Rein, M.S., Friedman, A., Barbieri, R.L. et al. (1991) Cytogenetic abnormalities in uterine leiomyomata. Obstet. Gynecol., 6, 923-926.
41. Schoenmakers, E., Kools, P., Mols, R. et al. (1994a) Physical mapping of chromosome 12q breakpoints in lipoma, pleomorphic salivary gland adenoma, uterine leiomyoma and myxoid liposarcoma. Genomics, 20, 210-222.
42. Schoenmakers, E., Mols, R., Wanschura, S. et al. (1994b) Identification, molecular cloning, and characterization of the chromosome 12 breakpoint cluster region of uterine leiomyomas. Genes Chrom. Cancer, 11, 106-118.
43. Schoenmakers, E.F.P.M., Wanschura, S., Mols, R. et al. (1995) Recurrent rearrangements in the high mobility group protein gene HMGI-C in a variety of benign mesenchymal tumors. Nat. Genet., 10, 436-444.
44. Stenman, G., Mark, J. and Ekedahl, C. (1984) Relationships between chromosomal patterns and proto-oncogenes in human benign mixed salivary gland tumors. Tumour Biol., 5, 103-117.
45. Stern, C., Kazmierczak, B., Thode, B. et al. (1991) Leiomyoma cells with 12q15 aberrations can be transformed in vitro and show a relatively stable karyotype during precrisis period. Cancer Genet. Cytogenet., 54, 223-228.
46. Stem, C., Deichert, U., Thode, B. et al. (1992) Eine zytogenetische Subtypisierung von 139 Uterus-Leiomyomen. Geburtsh. u. Frauenheilk., 52, 767-772.
47. Turc-Carel, C., Dal Cin, P., Boghosian, L. et al. (1988) Consistent breakpoints in region 14q22-q24 in uterine leiomyoma. Cancer Genet. Cytogenet., 32, 25-31.
48. Turc-Carel, C., Dal Cin, P., Sait, S. et al. (1989) Chromosomes in adipose tissue tumors. An evaluation of 75 cases. Cancer Genet. Cytogenet., 42, 230-235.
49. Van de Ven, W.J.M., Schoenmakers, E., Wanschura, S. et al. (1995) Molecular characterization of MAR, a multiple aberration region on human chromosome 12q13-15 implicated in various solid tumors. Genes Chrom. Cancer, 12, 296-303.
50. Vanni, R. and Lecca, U. (1988) Involvement of the long arm of chromosome 12 in chromosome rearrangements of uterine leiomyoma. Cancer Genet. Cytogenet., 32, 33-34.
51. Vanni, R., Nieddu, M., Paoli, R. and Lecca, U. (1989) Uterine leiomyoma cytogenetics. I. Rearrangements of chromosome 12. Cancer Genet. Cytogenet., 37, 49-54.
52. Vanni, R., Lecca, U. and Faa, G. (1991) Uterine leiomyoma cytogenetics II. Report of forty cases. Cancer Genet. Cytogenet., 53, 247-256.
53. Vanni, R., Dal Cin, P., Marras, S. et al. (1993) Endometrial polyp: another benign tumor characterized by 12q13-15 changes. Cancer Genet. Cytogenet., 68, 32-33.
54. Wanschura, S., Hennig, Y., Deichert, U. et al. (1995a) Molecular cytogenetic refinement of the 12q14-15 breakpoint region affected in uterine leiomyomas. Cytogenet. Cell Genet., 71, 131-135.
55. Wanschura, S., Kazmierczak, B., Schoenmakers, E.F.P.M. et al. (1995b) Regional fine mapping of the multiple aberration region involved in uterine leiomyomas, lipomas, and pleomorphic adenomas of the salivary gland to 12q15. Genes Chrom. Cancer, 14, 68-70.
56. Wanschura, S., Kazmierczak, B., Pohnke, Y. et al. (1996) Transcriptional activation of HMGI-C in three pulmonary hamartomas each with a der(14)t(12;14) as the sole cytogenetic abnormality. Cancer Lett., in press.
57. Youssoufian, H., McAfee, M. and Kwiatkowski, D.J. (1990) Cloning and chromosomal localization of the human cytoskeletal α-actin gene reveals linkage to the β-spectrin gene. Am. J. Hum. Genet., 47, 62-72.
58. Zhou, X., Benson, K. F., Ashar, R. and Chada, K. (1995) Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature, 376, 771-774.