Expression of hMSH2 and hMLH1 in colorectal carcinomas with microsatellite instability

Pathology Research and Practice

Volumn 194, Issue 1, 1998, Pages 3-9

  Kim, Hoguen ^a   Piao, Zhe ^a   Kim, Jae Woo ^a   Choi, Jin Sub ^a   Kim, Nam Kyu ^a   Lee, Jae Myun ^a   Park, Jeon Han ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Colorectal carcinoma; hMLH1; hMLH2; Microsatellite instability

Indexed keywords

AGED; ARTICLE; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR GENE; PROTEIN EXPRESSION;

EID: 0031904863     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(98)80006-X     Document Type: Article

References (33)

1. Aaltonen LA, Peltomaki P, Leach FS, Sistonen P, Pylkkanen L, Meckin JP, Jarvinen H, Powell SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B, de la Chapelle A (1993) Clues to the pathogenesis of familial colorectal cancer. Science 260: 812-816
2. Borrenson AL, Lothe RA, Meling GI, Lystad S, Morrison P, Lipford J, Kane MF, Rognum, TO, Kolodner RD (1995) Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas. Hum Mol Genet 4: 2065-2072
3. Bretnall TA, Chen R, Lee JG, Kimmey MB, Bronner MP, Haggit RC, Kowdley KV, Hecker LM, Byrd DR (1995) Microsatellite instability and k-ras mutations associated with pancreatic adenocarcinoma and pancreatitis. Cancer Res 55: 4264-1267
4. Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK, Kane M, Earabino C, Lipford J, Lindblom A, Tannergard P, Bollag RJ, Godwin AR, Ward DC, Nordenskjold M, Fishel R, Kolodner R, Liskay RM (1994) Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368: 258-261
5. Burks RT, Kessis TD, Cho KR, Hedrick L (1994) Microsatellite instability in endometrial carcinoma. Oncogene 9: 1163-1166
6. Egawa S, Uchida T, Suyama K, Wang C, Ohori M, Irie S, Iwamura M, Koshiba K (1995) Genomic instability of microsatellite repeats in prostate cancer: relationship to clinicopathological variables. Cancer Res 55: 2418-2421
7. Gao X, Wu N, Grignar D, Zacharek A, Liu H, Salkowski A, Li G, Sarkar F, Porta AT, Chen YQ, Honn KV (1994) High frequency of mutator phenotype in human prostate adenocarcinoma. Oncogene 9: 2999-3003
8. Goelz SE, Hamilton SR, Vogelstein B (1985) Purification of DNA from formaldehyde-fixed and paraffin-embedded human tissue. Biochem Biophys Res Commun 130: 118-126
9. Gonzalez-Zulueta M, Ruppert JM, Tokino K, Tsai YC, Spruck CH III, Miyao N, Nichols PW, Hermann GG, Horn T, Steven K, Sumnerhayes IC, Sidransky D, Jones PA (1993) Microsatellite instability in bladder cancer. Cancer Res 53: 5620-5623
10. Han HJ, Yanagisawa A, Kato Y, Park JG, Nakamura Y (1993) Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res 53: 5087-5089
11. Han HJ, Yuan Y, Ku JL, Oh JH, Won YJ, Kang KJ, Kim KY, Kim S, Kim CY, Kim JP, Oh NG, Lee KH, Choe KJ, Nakamura Y, Park JG (1996) Germline mutations of hMLH1 and hMSH2 genes in Korean hereditary nonpolyposis colorectal cancer. J Natl Cancer Inst 88: 1317-1319
12. Hoang JM, Cottu PH, Thuille B, Salmon RJ, Thomas G, Hamelin R (1997) BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines. Cancer Res 57: 300-303
13. Ionov YM, Peinado A, Malkhosyan S, Shibata D, Perucho M (1993) Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363: 558-561
14. Jen J, Kim, H, Piantadosi S, Liu JF, Levitt RC, Sistomen P, Kinzler KW, Vogelstein B, Hamilton SR (1994) Allelic loss of chromosome 18q and prognosis in colorectal cancer. New Engl J Med 331: 213-221
15. Kim H, Jen J, Vogelstein B, Hamilton SR (1994) Clinical and pathological characteristics of sporadic carcinoma with DNA replication errors in microsatellite sequences. Am J Pathol 145: 148-156
16. Kolodner RD, Hall NR, Lipford J, Kane MF, Morrison PT, Finan PJ, Burn J, Chapman P, Earabino C, Merchant E, Bishop DT (1995) Structure of human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations. Cancer Res 55: 242-248
17. Konishi M, Kikuchi-Yanoshita R, Tanaka K, Muraoka M, Onda A, Okumura Y, Kishi N, Iwama T, Mori T, Koike M, Ushino K, Chiba M, Nomizu S, Konishi F, Utsunomiya J, Miyaki M (1996) Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology 111: 307-317
18. Leach FS, Nicholaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomaki P, Sistonen P, Aaltonen LA, Nystrom-Lahti M, Guan XY, Zhang J, Meltzer PS, Yu JW, Kao FT, Chen DJ, Cerosaletti KM, Fournier REK, Todd S, Lewis T, Leach RJ, Naylor SL, Weissenbach J, Mecklin JP, Jarvinen H, Petersen GM, Hamilton SR, Green J, Jass J, Watson P, Lynch HT, Trent JM, de la Chapelle A, Kinzler KW, Vogelstein B (1993) Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75: 1215-1225
19. Leach FS, Polyak K, Burrell M, Johnson KA, Hill D, Dunlop MG, Wyllie AH, Peltomaki P, de la Chapelle A, Hamilton SR, Kinzler KW, Vogelstein B (1996) Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues. Cancer Res 56: 235-240
20. Liu B, Farrington SM, Petersen GM, Hamilton SR, Parsons R, Papadopoulos N, Fujiwara T, Jen J, Kinzler KW, Wyllie AH, Vogelstein B, Dunlop MG (1995) Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nature Genet 9: 48-55
21. Lothe RA, Peltomaki P, Meling GI, Aaltonen LA, Nystrom-Lahti M, Pylkkanen L, Heimdal K, Andersen TI, Moller P, Rognum TO, Fossa SD, Haldorsen T, Langmark F, Brogger A, de la Chapelle A, Borrenson AL (1993) Genomic instability in colorectal cancer: relationship of clinicopathological variables and family history. Cancer Res 53: 5849-5852
22. Mao L, Schoenberg MP, Scicchtano M, Erozan YS, Merio A, Schab D, Sidransky D (1996) Molecular detection of primary bladder cancer by microsatellite analysis. Science 271: 659-662
23. Merio A, Mabry M, Gabrielson E, Vollmer R, Baylin SB, Sidransky D (1994) Frequent microsatellite instability in primary small cell lung cancer. Cancer Res 54: 2098-2101
24. Mironov NM, Aguelon MA, Potapova GI, Omori Y, Gorbunov OV, Klimenkov AA, Yamasaki H (1994) Alterations of (CA)n DNA repeats and tumor suppressor genes in human gastric cancer. Cancer Res 54: 41-44
25. Nicholaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Dunlop MG, Hamilton SR, Petersen GM, de la Chapelle A, Vogelstein B, Kinzler KW (1994) Mutations of two PMS homologues in hereditary non polyposis colon cancer. Nature 371: 75-80
26. Papadopoulos N, Nicholaides NC, Wei YF, Ruben SM, Carter KC, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Hamilton SR, Petersen GM, Watson P, Lynch HT, Peltomaki P, Mecklin JP, de la Chapelle A, Kinzler KW, Vogelstein B (1994) Mutation of a MutL homolog in hereditary colon cancer. Science 263: 1625-1629
27. Parsons R, Meyerhoff L, Liu B, Wilson JKV, Markowitz S, Kinzler KW, Vogelstein B (1995) Microsatellite instability and mutations of the transforming growth factor type II receptor gene in colorectal cancer. Cancer Res 55: 5548-5550
28. Risinger JI, Berchuck A, Kohler MF, Watson P, Lynch HJ, Boyd J (1993) Genetic instability of microsatellites in 7ndometrial carcinoma. Cancer Res 53: 5100-5103
29. Schriber E, Matthias P, Muller MM, Schaffner W (1989) Rapid detection of octamer binding proteins with 'miniextracts', prepared from a small number of cells Nuc Acids Res 17: 6419
30. Thibodeau SN, Bren G, Schaid D (1993) Microsatellite instability in cancer of the proximal colon. Science 260: 816-819
31. Thibodeau SN, French AJ, Roche PC, Cunningham JM, Tester DJ, Lindor NM, Moslein G, Baker SM, Liskay M, Burgart LJ, Honchel R, Halling KC (1996) Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res 56: 4836-4840
32. Uchida T, Wada C, Wang C, Egawa S, Ohini H, Koshiba K (1994) Genomic instability of microsatellite repeats and mutations of H-, K-, and N-ras, and p53 genes in renal cell carcinoma. Cancer Res 54: 3682-3685
33. Uchida T, Wang C, Wada C, Iwamara M, Egawa S, Koshiba K (1996) Microsatellite instability in transitional carcinoma of the urinary tract and its relationship to clinicopathologic variables and smoking. Int J Cancer 69: 142-145